Basic Information

Insect: Drosophila merina
Gene Symbol: zfh1
Assembly: GCA_035047645.1
Location: JAWNPH010000002.1:28004221-28023725[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0017 0.16 12.7 1.6 2 23 73 95 72 95 0.95

2 9 0.015 1.4 9.8 0.1 1 23 308 330 308 330 0.96

3 9 9.4e-05 0.0086 16.7 1.7 2 23 344 365 343 365 0.97

4 9 4.6e-06 0.00042 20.8 6.3 1 23 374 396 374 396 0.99

5 9 0.00027 0.025 15.2 1.2 3 21 404 422 402 423 0.94

6 9 0.0063 0.57 10.9 0.7 2 21 647 666 646 667 0.92

7 9 8.9e-06 0.00081 19.9 0.5 1 23 985 1007 985 1007 0.95

8 9 4.5e-05 0.0041 17.7 7.4 1 23 1013 1035 1013 1035 0.98

9 9 0.0023 0.21 12.3 4.3 1 21 1041 1061 1041 1062 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0017	0.16	12.7	1.6	2	23	73	95	72	95	0.95
2	9	0.015	1.4	9.8	0.1	1	23	308	330	308	330	0.96
3	9	9.4e-05	0.0086	16.7	1.7	2	23	344	365	343	365	0.97
4	9	4.6e-06	0.00042	20.8	6.3	1	23	374	396	374	396	0.99
5	9	0.00027	0.025	15.2	1.2	3	21	404	422	402	423	0.94
6	9	0.0063	0.57	10.9	0.7	2	21	647	666	646	667	0.92
7	9	8.9e-06	0.00081	19.9	0.5	1	23	985	1007	985	1007	0.95
8	9	4.5e-05	0.0041	17.7	7.4	1	23	1013	1035	1013	1035	0.98
9	9	0.0023	0.21	12.3	4.3	1	21	1041	1061	1041	1062	0.96

Sequence Information

Coding Sequence: ATGTTGTCCTGTTTGGCGCCGTCGTCTTCACGTTTCGGCCAAAAGGATACCATCATTCAGCAGAGCATGCCATCCACAGCCTTCACCATGCAGTTTCCCTCGCTGGCCTCTAGTCTGCACCACCATAACCATAACCAGTCGCCGCACCACAGCAAGCCCGGACCCCAGGATGGCCAGCACGTGCAACCAGGTGCCGCCGCCGACGATTTTCTGGTCAAGTGCACCCAGTGCCACCAGCGCTTCACGGACTTCCAGTCCCTTAGCGAACACATTGCCAGCGAGCATCCCCACGACAAGCTGAACCTGGGAGCAGCGCAACCGGAGAGTGAGCCGGAGGACGAGCAGAGCAACCTGAGCAGCGGCAGTCGGCGGTACTTGAAGTCGCCGGAGAACACGAATGCCAACGGCGGCAGCGGTATTGCCAACtccagcaataacaacaacaacaacagtgaTCTGGCCAAAAACcacaacaacaccaacaagCTGTCACCCATGTGCTCGCCCATTTCCGGTGTAGGAATGGGCGGAGTGGGATCGGGTCCACCCAGCGATCTGTTTGCCCACCTCTCCCACGGCACGCCCCAGCTGCCCGGCCAGCTGCCCGCCCACCTGCAAGCCCAGTTCATGGCCGCCGCCGCCCTGGCCATGCAATCCGCCCGCTCcgccagctccagctccccCAGCAGCCACCACCAGTCGCAGCagtcccagcagcagcagcagcaatcctCGCAACTGCAACTCCAGCAataccaccaccagcagcagcagcaacagcaacaccagccGCCCCTGCTGCCGCCCCAGCTCCCGGGGAGCAACAGCAGCGTGGGCAGCAACTCCGCCTACGACCTGGATCTGAGTGCTCCGCGGTCCACCTCCAGCCCCGGCTCCACCACCGGGGATCTCAGCGGTGCCTATCCCTGCATGCAGTGCACCGCCGCCTTCGGCTCCAGGGAGCAGCTGGAGCAGCACGAGCTCCTCCACTCGCCCTGCGGCCAGCCAGCGACGCAGAACGTCTCACAGACCTGCCGCATCTGCCACAAGGCCTTCGCCAATGTCTACCGACTCCAGAGGCACATGATCAGCCACGATGAGAGCGCCCTGCTGAGGAAATTCAAGTGCAAGGAGTGCGACAAGGCCTTCAAGTTCAAGCACCACCTCAAGGAGCACGTGAGGATCCATTCCGGCGAGAAGCCGTTCGGGTGTGACAACTGCGGCAAGCGGTTCTCCCACTCTGGCAGCTTTTCCTCCCACATGACCTCCAAGAAGTGCATCAGCATGGGCCTCAAGCTGAACAACAACCGGGCGCTGCTGAAGAGATTAGAGAAGCGTCCCGGTTCAGGCGCGTCGGCTCGCCTCTCGCCCTCGGACCAGGCCAAGGGAAAGCTCCAGGAGCAGCAGGCATTGCCGGGTCTGCCGAATCCCATGATTTACTTTGCCAGCGATGCCCAGAACCAGGCTGGGAACAACGGACCCGCCTCATTTCCGAATTTCCATCCCACGAACTACATGAATGCCGCCCTGCTGGCCTTTCCCAATCCCTTCATGGCAGCTGCCGCCCTGGATCCTCGCATGCATCCCTACAGCATACAGCGATTGCTGCAACTGACGGCTGCAGGTCAGCAACAGAGGGAGGAGGAGCAGCGGGAGCAGGAGAACCAGGaagagcaggaggaggagacaCCCGAGGAACCCAAACTGGTGATGGATATCGATGTTCCGGAGATCAAGGAACGGGCTGTCACCCCTCCGATCCACGAGGAAGCCGCTCCCATCAAGCAGGAAGCCAGTCGCGAAGCCTCTCCGGCTCCGGAAAGCTCTCCACCATCTCCGCAGGTCGTCAAGCAAGAAGTGGAGGCGCCACCGCAAGAACCAGAGCCTGAGATCATGGACGAAGAACCCATTCCAGCTCCCGAGCAGCCCGCTGACCTGCGCTGCAGTCGCTGCTCCAAGCAGTTCAACCATCCCACGGAACTGGTCCAGCACGAAAAGGTCCTTTGCGGCCTAATCAAGGAGGAAATGGAGCAGCActtccagcagcagcaacagcagcagcggaaCCTGCAACCCCCAGCCTTTGTCCTGCCGTCCGCAAGCGAGGAAGACGAtgaggaggacgaggaggaggagcccAGGAACCAGGAGACTGGCGAACGCAAAGTCCGCGTCCGCACCGCCATCAACgaggagcagcaacagcaactgaaGCAACATTATTCCTCGAATTCCCGACCCAGCAGGGACGAGTTCCGCTTGATAGCCGCCAGGTTGCAGCTGGATCCGCGGGTAGTCCAGGTCTGGTTCCAAAACAATCGCTCGCGGGAGCGCAAGATGCAGAGTTTCCAGAGCAACCAAAGTGCCACGGCCCCAGCCGCAAGCGAATCCCAAGGAAATGGGGATCAGCCTCTGGATCTGTCCATTAAGCGGGATCCTCTGACCCCGAAGAGTGAGAGCTCGCCATCCTACTTGCCTCCCCAAACGGCCGAAGGACTCAATCCGGAAGCCATCAATCTGAGCCGAAAGTTCTCCAGCTCAGCTTCGATGTCCCCGGCTTCGATTTCTCCCTCATCCGCGGCAGCTTTGTATTTTGGAGCTGCCCCACCGCCATCGCCGCCCAACAACCAAATGGAGGCGAACCCTTCCCGCAGCGGGCAAGCCTTTCCGGGTCTGCCCTACATGCTGCCCATGCAGCGACTGCCCATGGAGGCGCTCTTCCAGATGCGACCAGGCGGAGAGTACGCCCCAAACCATCCCCTGATGAACAGTATTAAGCTGCCCGACTACCGAGGCACCAGCCTAAGCCCGGGCGGATCGGAGAAGCGCTCCTGGCGCGACGATGACTCGCGCATCTCGCACGAGGATGACTTTTCCGGCGGCCTGCTGCCCCCGAAGCCGAGGCGCGGCAAGGCGGAGACCCATGGACACGCCGGCGATCCGGACTTGCCATACGTCTGCGATCAGTGCGACAAAGCCTTCGCCAAGCAGAGCTCCCTAGCCCGGCACAAGTACGAGCATTCCGGTCAACGACCCTACCAGTGCATGGACTGCCCCAAGGCCTTCAAGCACAAGCATCATCTGACGGAGCACAAGCGCCTCCACAGCGGGGAGAAGCCCTTTCAGTGCTCCAAGTGCCTGAAACGCTTCTCGCACTCGGGCAGCTACAGCCAGCACATGAACCACCGCTACTCCTACTGCAAGCCCTACAGGGAATAG
Protein Sequence: MLSCLAPSSSRFGQKDTIIQQSMPSTAFTMQFPSLASSLHHHNHNQSPHHSKPGPQDGQHVQPGAAADDFLVKCTQCHQRFTDFQSLSEHIASEHPHDKLNLGAAQPESEPEDEQSNLSSGSRRYLKSPENTNANGGSGIANSSNNNNNNSDLAKNHNNTNKLSPMCSPISGVGMGGVGSGPPSDLFAHLSHGTPQLPGQLPAHLQAQFMAAAALAMQSARSASSSSPSSHHQSQQSQQQQQQSSQLQLQQYHHQQQQQQQHQPPLLPPQLPGSNSSVGSNSAYDLDLSAPRSTSSPGSTTGDLSGAYPCMQCTAAFGSREQLEQHELLHSPCGQPATQNVSQTCRICHKAFANVYRLQRHMISHDESALLRKFKCKECDKAFKFKHHLKEHVRIHSGEKPFGCDNCGKRFSHSGSFSSHMTSKKCISMGLKLNNNRALLKRLEKRPGSGASARLSPSDQAKGKLQEQQALPGLPNPMIYFASDAQNQAGNNGPASFPNFHPTNYMNAALLAFPNPFMAAAALDPRMHPYSIQRLLQLTAAGQQQREEEQREQENQEEQEEETPEEPKLVMDIDVPEIKERAVTPPIHEEAAPIKQEASREASPAPESSPPSPQVVKQEVEAPPQEPEPEIMDEEPIPAPEQPADLRCSRCSKQFNHPTELVQHEKVLCGLIKEEMEQHFQQQQQQQRNLQPPAFVLPSASEEDDEEDEEEEPRNQETGERKVRVRTAINEEQQQQLKQHYSSNSRPSRDEFRLIAARLQLDPRVVQVWFQNNRSRERKMQSFQSNQSATAPAASESQGNGDQPLDLSIKRDPLTPKSESSPSYLPPQTAEGLNPEAINLSRKFSSSASMSPASISPSSAAALYFGAAPPPSPPNNQMEANPSRSGQAFPGLPYMLPMQRLPMEALFQMRPGGEYAPNHPLMNSIKLPDYRGTSLSPGGSEKRSWRDDDSRISHEDDFSGGLLPPKPRRGKAETHGHAGDPDLPYVCDQCDKAFAKQSSLARHKYEHSGQRPYQCMDCPKAFKHKHHLTEHKRLHSGEKPFQCSKCLKRFSHSGSYSQHMNHRYSYCKPYRE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00615732;
90% Identity: iTF_00550414;
80% Identity: iTF_00545870;