Dtro004310.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila tropicalis
Gene Symbol
-
Assembly
GCA_018151085.1
Location
JAECWH010000669.1:803304-805239[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 4.6e-05 0.0035 17.8 2.8 1 23 125 147 125 147 0.96
2 11 7.8e-07 6e-05 23.3 2.6 1 23 153 176 153 176 0.97
3 11 2.3e-05 0.0018 18.7 0.6 1 23 182 204 182 204 0.97
4 11 1.5e-05 0.0012 19.2 0.4 1 23 210 232 210 233 0.95
5 11 1.5e-06 0.00012 22.4 0.9 1 23 240 262 240 262 0.97
6 11 0.0041 0.31 11.6 1.1 1 23 268 291 268 292 0.95
7 11 0.00038 0.029 14.9 0.5 1 23 297 319 297 319 0.97
8 11 2e-05 0.0016 18.8 2.7 1 23 325 347 325 347 0.98
9 11 1.9e-05 0.0014 19.0 4.7 1 23 353 375 353 375 0.99
10 11 0.0057 0.44 11.1 1.1 1 23 381 406 381 406 0.92
11 11 0.0014 0.11 13.1 0.5 1 19 412 430 412 432 0.95

Sequence Information

Coding Sequence
ATGGCACGCAGCCGTCGTAGTTTGTCCAAAGAGGATGCCGTGTCCCTGCTTACAGACAGTGGCATATCGCTATCATCGCCGCCGGCGGCGGGCAGAGACTCCTCATCGCCCACAACAACAGCAACATCGACATCGACATCGACATTATCGATTAAACGTCGGAAGAGCAGTCTACTAAGGGACAACAACAACTATGCGGAAGCCGATGAAGAGGATGGTGAAGACGGTGGTGACACAACGGAACAGGATTCCCGTGATGCCGACTATATCCAACCCTTGCCCAAAAAATCATTAAGAAAATCATCAATATCGTTAGCCTCATCATCAGCATCAGCATCGGGATCGTCATCCGAATCGGGACGTCGCAAACAGCATATATGTACGCATTGCTCCAAAGAGTTTGGTGGTAAGACTGATCTGCAACGCCATATGCTAATCCATTCGGATGAGCGGCCTCACAAGTGTGCCGATTGTGGTAAATGTTATCGCCAGGCCGTGAATCTTAAGAACCACATAACCACCGCACATGAGCATAAGAAACAATTTGCTTGTAGCCAGTGTCCCAAATCGTTTGCCCTCAAAGAGCGTCTGCGTCTCCACATGCGTTTGCATTCGGGCGAGAAGCCATATCCATGTGCTCTCTGTGATAAGCGTTTCGCACGAGGTGGTCAGCTCCAGCAGCATATGGTGTCGCATCATAAGACAAGTATACAGCAATTTAATTGTACCAAATGCTCGGCCAGTTTCTCAACCAATGCCAATCTGCGTGTTCACATGGAGAGGCACGAGCAGGGCATGGAGCATAGATGCACAATCTGCGAGAATCAATTTGCCAACGAATTGGCTCTGCGGGCTCACATCAATCAGGAGCATCATAAGCTCACCAAATTTGATTGTGAAATATGCCACAAAAGCATTGAATCGGATGAGGATCTTGCCACACATATGCAAAAGCATGCGGCCATCAAGACGCATGTCTGTGAGGTGTGCAATTCGTATTTTACTCAGAAATCGCAATACAATGTTCATATGCGTATGCATACAGGCGAACGGCCATATCAATGTCGGATTTGTCATCAAACATTTGCCCATTCGAGTGTATTGAAACTGCATATACGTAAGCATACGGGTGAGAAACCATTTCGTTGTCTCCTTTGTACCGATGAAGTGGCCTTCTCCCAGTTGGCCCACCTCAAGAATCACATGAAGAAAATCCACAAACAGCAGAAACCCTACATGTGTCACGGTTGTCATGAGTTCTTTAAAATCAAAGTGGAATTGCAAGCACATGCGGAACAGTGTGTCAAATGCCAGAAATCAGGCGATGAGGATGACAATCAGAATGAAAATGCCCAGGCATTGTCCACCATGCGTTTCAATATGGCCGTGGTGCTTAAGAAAATAAGCTCCGCTCAAAAGCTACGTCAATTGGGCTATGAGAAACGTTTAATTGACAATGTCATAATTGCTTCACTCAAGTTGGCTCAACGTCCGGCTCACGATGATGCCCAATTGACGCCTTTGGCCCGCCTACGCCTCAATGTCGAGGAATTTCTCAAGTGGATTGTCCCGGCGCCGACCATGCAGAAATTCGGCGAAGAGTTGCTCTCGATTGAGACCATTCTGGATAAGATTGCCGCCATGTATATGAAGCAGAAGTAG
Protein Sequence
MARSRRSLSKEDAVSLLTDSGISLSSPPAAGRDSSSPTTTATSTSTSTLSIKRRKSSLLRDNNNYAEADEEDGEDGGDTTEQDSRDADYIQPLPKKSLRKSSISLASSSASASGSSSESGRRKQHICTHCSKEFGGKTDLQRHMLIHSDERPHKCADCGKCYRQAVNLKNHITTAHEHKKQFACSQCPKSFALKERLRLHMRLHSGEKPYPCALCDKRFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCTICENQFANELALRAHINQEHHKLTKFDCEICHKSIESDEDLATHMQKHAAIKTHVCEVCNSYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCLLCTDEVAFSQLAHLKNHMKKIHKQQKPYMCHGCHEFFKIKVELQAHAEQCVKCQKSGDEDDNQNENAQALSTMRFNMAVVLKKISSAQKLRQLGYEKRLIDNVIIASLKLAQRPAHDDAQLTPLARLRLNVEEFLKWIVPAPTMQKFGEELLSIETILDKIAAMYMKQK