Dtri012763.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila trichaetosa
Gene Symbol
prg
Assembly
GCA_035043205.1
Location
JAWNNE010000535.1:7563421-7565283[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.24 16 6.2 1.1 1 19 225 243 225 248 0.85
2 9 0.0022 0.14 12.6 0.1 1 23 254 277 254 277 0.97
3 9 5.4e-06 0.00036 20.8 0.3 1 23 283 305 283 305 0.97
4 9 1.1e-07 7.4e-06 26.1 4.3 1 23 311 333 311 333 0.98
5 9 2.9e-05 0.0019 18.5 0.6 1 23 339 361 339 361 0.98
6 9 5.9e-05 0.0039 17.6 0.3 1 23 367 389 367 389 0.98
7 9 3.3e-05 0.0022 18.3 0.5 1 23 463 485 463 485 0.96
8 9 2.1e-05 0.0014 19.0 0.2 1 23 490 513 490 513 0.91
9 9 0.081 5.3 7.7 0.3 1 23 517 539 517 539 0.98

Sequence Information

Coding Sequence
ATGCTTGATTTAACAACGATCGACGTAGGAACACTTAATTGGGATCAGAAAAATGATCAAAAATTAACATCGGAGTCAATGCGATGTCGCTTGTGTCACTCACGGATAAAATCGAACACAGATTCGCCGAATATTTACGAGGCGTCTGTTTACTTTGGccaggaagaagaagaagatttaagaacagaagaaaaaatcataattgcCGATGTTTGCCAGAGTGTTTATGGTGTGAAATATGAGCGCCATGAGTTACTGTCGGAGCACATCTGTATGCGCTGCCTGGAGATATTGAGGGACTTCTACGAGCAACGTCAGTACATGCAGCAGCATGAATTGGAGCTGCAGCAGAAcctaaagaaaataattgctGTGGATGCCAAGTATCGACCTGGCCTTAACGGCAATCCAGGCGAGTTTGAATTCGGGGAAGGCGAAGAAATTGTCGATGTGGATCCCGAGCAACTGTGCGAGACGAGTGATGACGAATTCCCCGGCTCCGAAGCTGAGCTCGATGACGAGGAATGggacgacgaggatgaggagggAGGACCTGCACAAAATGAAGAAACCGAGATGCCCCTCGGCATGGATGCCGCCCAAATGGCGATGATGCGAGTGCATCAAACGGTCGACACCAGCGTCCAATTCAATGCGCATCCAAAGAGCGCCTTCCTCTGTCAGTACTGCGATCTGGCCTTCACCCTACAGTCGGACTGCCAGCAACATGAGGTGGGCTCCCACGACTCCTCGGCGCCGTACACTTGCAACTACTGTCAGGTGAGATTGATGACGCGTCCGGCTTTAATTGCGCACATCAGGGAGCTGCATGACGCCGAGCGTCCCTATGTGTGCGCATTGTGCAGCAAGGGATTCGTGAGACGTTCGGACTTGAAGAAACACACAATTGTGCATACGGGCGTGCGTCCGTTCTCGTGCCACGTTTGCTCCAAAAGCTTCTCGCGCAACACCAATCTGACCAAGCATCTGCGCATCCACAGCAGCGTGAAGCCGTTCGTCTGCCAGCAGTGTCCGCGCTCTTTCCAGACACCGCTGGAGCTGCTGAAGCACACGCGCTCCCATGCCGAAGTAAAACCGTTCCGGTGCGGACGCTGCCCCGCCTCGTTCGCCCGCAAGGATAAGCTATTGATGCATCAGCAAGTTCATCTCAAGCGCGACATcgagcaaaagcaaagtcaaAATCTGCGTATCAATATGATGATGCCGGCAGAGCAGATGCAAGTGCAGCTGCCACTGCATCCGTACGTGGAGGCAGATGCATCGGCCCAACAGGCCTTACCAGCTATAACAACATATCCCTATCAGCAGCAAACGCCTCCCGCGATGCAGCCAAAGGTGAAAGCATCGTCGAAGGTAACGCGCAATTTCCGCTGCGATGTATGCGATCGCGGCTTCCAACGAGAGCGGGATCTGCAGCGCCATCGGGCCCTGCACATGGACACACTATTCGCCTGCAAACTGTGCGGCCAGGGCTTTAATCGGCGCGAGCAACTGCAGCGTCACGAGCTGGAGGCTCATGGGCCCAGCTATACATGTGCTATTTGTTGCATCGCTTTCCTACAGCAGGCGGAGCTGGAGACGCATCTTAAAGTGCACGAGCTACAGCACAGTGTGGCCAAAAGCAACCAGGAGGCGTTAATAGCTGCCGCCGCTGTAGTACCGCTAGCTCATTCCATGGGCGAGCACACGGGTGTCCCAGTGCCAGCCATCGTTCCGGAGCCCGTCCAGCTACCCAATGTTAGGCCTTCCGCAGCTGAAATGTCCTTCTATAGCAACATGATACCTACCATGAATCTAGGCTTCTACAGCGAGACGCGTCCCGATGAGAGCAACGGAGTTTAA
Protein Sequence
MLDLTTIDVGTLNWDQKNDQKLTSESMRCRLCHSRIKSNTDSPNIYEASVYFGQEEEEDLRTEEKIIIADVCQSVYGVKYERHELLSEHICMRCLEILRDFYEQRQYMQQHELELQQNLKKIIAVDAKYRPGLNGNPGEFEFGEGEEIVDVDPEQLCETSDDEFPGSEAELDDEEWDDEDEEGGPAQNEETEMPLGMDAAQMAMMRVHQTVDTSVQFNAHPKSAFLCQYCDLAFTLQSDCQQHEVGSHDSSAPYTCNYCQVRLMTRPALIAHIRELHDAERPYVCALCSKGFVRRSDLKKHTIVHTGVRPFSCHVCSKSFSRNTNLTKHLRIHSSVKPFVCQQCPRSFQTPLELLKHTRSHAEVKPFRCGRCPASFARKDKLLMHQQVHLKRDIEQKQSQNLRINMMMPAEQMQVQLPLHPYVEADASAQQALPAITTYPYQQQTPPAMQPKVKASSKVTRNFRCDVCDRGFQRERDLQRHRALHMDTLFACKLCGQGFNRREQLQRHELEAHGPSYTCAICCIAFLQQAELETHLKVHELQHSVAKSNQEALIAAAAVVPLAHSMGEHTGVPVPAIVPEPVQLPNVRPSAAEMSFYSNMIPTMNLGFYSETRPDESNGV