Dsub015283.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila suboccidentalis
Gene Symbol
PZF1
Assembly
GCA_037043435.1
Location
JBAMBK010002334.1:30598-34751[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.078 5.7 7.8 0.2 3 23 324 345 323 345 0.91
2 10 9.8e-05 0.0072 17.0 0.3 6 23 354 371 354 371 0.99
3 10 1.1e-05 0.00079 20.0 0.3 1 23 377 400 377 400 0.98
4 10 0.00012 0.0085 16.7 0.8 1 23 412 434 412 434 0.98
5 10 0.00014 0.01 16.5 5.0 1 23 441 464 441 464 0.96
6 10 1.5e-05 0.0011 19.5 1.8 1 23 470 492 470 492 0.96
7 10 0.19 14 6.6 1.0 2 23 501 522 500 522 0.96
8 10 0.00023 0.017 15.8 1.9 2 23 528 550 527 550 0.92
9 10 2.3e-07 1.7e-05 25.3 0.7 2 23 557 578 556 578 0.97
10 10 0.00023 0.017 15.8 4.4 1 23 584 607 584 607 0.96

Sequence Information

Coding Sequence
ATGATCTGTCGCTTGTGCTTAAAAAGCATAAACTCAAACAATGCCGTCTACCTGTTTGAAACGAACGACACACTAGCCGAATCCTCGTTGCTCAAAATGATAGCAAAGTTTCTGCAACTCGAAATAATGCCGGATGATAACATTTCGACAAACATTTGCCACGAGTGCTGTGAGCATCTGGAGGACTTCAACAACTTCTGGCAGCTGGTGGAACAAAAACAGGCGACACTCAAAAATGAATTCCTCAACGTGGACGTCGATTGTGTCGCCCTCAAATGGACGGGCGGCATCGATGTGGACGTGAGCATTGACGAGCTGCCGCTCGTGGCCGATGAGATGGACGAGAAGCCTTTAGATATTCATAATCTCAGTCTGCTTGGCAGTGTGCTCGATGTCAATGTGGACAGTGTCGAGGTGCCGCATTCAAAGCAAGCGCAGCGCAAGCAATTAATATTGACAAATTTAGCTGAGCATGATTGTGATATTGCGGATGAGAAGCCGCTAATCAATGACAGCAGtggccacagcaacaacagtgcgAGAAACTTTCTCTCTTCATCCTCCTCCCCCTcagcctcctcctcctgttcCACCCCTTCcgctaatgataatgatgatgatgatgaCGAAGTGCCTCTGGTGAAGCTGCAGCACAAACTGAAGCCGAAGCGGAAAGTGCGCGCGACGCGTCGCAAGCAGCGCACATTGACTCTGGCCCAGGAGCTGGATCAGCTGCTGGAGGAGAGCAACGTTGACAGCAAGAGGAAGGTGCGACGCAAGAAACTGAGAAATACAAATGCCATAGCAATGGTTAttgcaaatacaaatgtaaatgcaaatgcaaatacgcCAACGGATTCACAAAAGGATGAACTGGAGGCGGCTATGGAACGGCGTCCCAAGGGCTGTTCCCGTGCCCAGCTATCGAAGCGCTACGAGGAGGCCATTGCCAGTTACATGAGGGCCGACTGTGATCTGTGCGATTTCAGCGCCAAGTACCTATCCCAGTTAAAAGTCCACTTCCTTGAGGTGCATCAACAGGATGCGTATCTCAAGTGCTGCAACAAGGTCTTCAATCGACCCTCTAAGCTCATGGATCACATACGCAAGCACATCAATCCCAAGCTCTTCACCTGTTCCATCTGCAACAAATCGTTAAACTCGCAGGATTATCTGGCCACGCATATAGAAACGGTGCACAATAAGGTTGCCAAGATTGGCAAGGTGCTCAAGTATCCGTGCTCCAAGTGCGAGCGAACCTTTAGTAGCGAACGTCGTCTGGCCAACCATGTGATGAAGCATGATACGGATCAGTTGGAGCACAGTTGTCACATTTGTGAAAAAAGCTTCGCCAATGTGCACCGGCTGAGACGACACATTCAGTCTATACACGAGGATCTGCATCCACATGTctgcgatatctgtggcaagAAGTTTAAATTCAAGCCCTCGTTCGAACGCCATCTGCTGGAGCATCAAGGCGTCGTCGCACCGGCCATGGAGTGCACCATCTGCGGCGTCTGGCTGAAGAATGAGCACAGTCTGCGACTGCATCGCTTCACGCACGATAGCACCAATACCGTCTGTCCGCATTGCTCCAAGACGTGCAGTTCGCGGACGGCGTTGCGGGCCCATGTCGAGTACGCGCACAAATTGACGACGAGTCTGCAGTGCACGTATTGCGAGAAGAGCTTCAAGCAGCAGCGGAATCTGGAGGAGCACATGGCCATACACACGGGACTGCAGTTGTACAATTGCCCGCATTGTCCCAAGGAGTGCCGCTCCCGATCCAACATGTATGTCCACATCAAGCAACGGCATGCGGATGAATGGCTCAAAGCGAAAATGGCTCGATCCCATAATCCACAGTTCAAGCCACATGCCTAG
Protein Sequence
MICRLCLKSINSNNAVYLFETNDTLAESSLLKMIAKFLQLEIMPDDNISTNICHECCEHLEDFNNFWQLVEQKQATLKNEFLNVDVDCVALKWTGGIDVDVSIDELPLVADEMDEKPLDIHNLSLLGSVLDVNVDSVEVPHSKQAQRKQLILTNLAEHDCDIADEKPLINDSSGHSNNSARNFLSSSSSPSASSSCSTPSANDNDDDDDEVPLVKLQHKLKPKRKVRATRRKQRTLTLAQELDQLLEESNVDSKRKVRRKKLRNTNAIAMVIANTNVNANANTPTDSQKDELEAAMERRPKGCSRAQLSKRYEEAIASYMRADCDLCDFSAKYLSQLKVHFLEVHQQDAYLKCCNKVFNRPSKLMDHIRKHINPKLFTCSICNKSLNSQDYLATHIETVHNKVAKIGKVLKYPCSKCERTFSSERRLANHVMKHDTDQLEHSCHICEKSFANVHRLRRHIQSIHEDLHPHVCDICGKKFKFKPSFERHLLEHQGVVAPAMECTICGVWLKNEHSLRLHRFTHDSTNTVCPHCSKTCSSRTALRAHVEYAHKLTTSLQCTYCEKSFKQQRNLEEHMAIHTGLQLYNCPHCPKECRSRSNMYVHIKQRHADEWLKAKMARSHNPQFKPHA