Dsec002953.1
Basic Information
- Insect
- Drosophila sechellia
- Gene Symbol
- MBD2
- Assembly
- GCA_004382195.1
- Location
- NC:18875902-18877945[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 8.7e-20 3e-16 58.4 0.0 1 58 9 87 9 105 0.91 2 2 1.2e-07 0.00041 19.5 0.0 27 76 178 238 129 239 0.87
Sequence Information
- Coding Sequence
- ATGCAAATGAACCCGAGCGTCACAATCGAGCGCAAACGCGTCGACTGCAGTGTCCTGCCAAAGGGATGGCAGCGCGACGAAGTCCGAAAGTCCGGCAGCAGCGCCAATAGTaacgccagcagcaacaacaacagcagcagtgccacagccagcagcaacaacaacaataacaaggtGGATGTTTTCTACTACAGCAGTCCCACAGGAAAAAGGGCGGAGGGAAAGCCGCAGGACATTGCAATCCCTGATTTCCAGTCTGGCAAGATGCCACACCGCGCCCTGCCCTCGCCCTCCATTTCACTGTACCGCTGCAGCGCCATGCCGCTGCCTATAGCGAGCGGGGGCGGTAATGGGGCCACCAGCGGATCGGCGGCCAATGCCCTCAAGCGCAAGTTCGCCCGGAGTCAAGGAGGCaatgctgcagcagcagcaggaggagctgctCCCTCGACAGCGACCGCCTCgtcagcagcatcagcatctgCTTCACCATCAACGGCCAatcgccagcagcaacagatcGAACTCAGCCGAGCCCTGCGCACAGATGTCTCCCTGGTGCCGCCCATTCGACAGACTGCCTCGATCTTCAAGCAACCGGTGACGGTGATTCGCAACCACAAGCAGGATCCCGCCAAAGCGAAGAATGATCCCAAGCATGGCACTCGGGAGAAGCCGAAACAGCTGTTCTGGGAGAAGCGACTGGAACGACTACGCGCCTGCCACGACAGCGGCGAGGAGCTAGACGACATCTCACTGCCCAAGACCATACGCACCGTTGGCCCCAATGTCAACGAACAGACCGTCCTCCAGTCGGTGGCCACGGCCCTGCATATGCTCAACGCCGGCGTACACGGCCAGAGTTCTACGAAGGTTGATTTGACCAAGAATGCCATGGCGTTTATGAATCCTGAACAGCCGCTCATGCACGCGGTGATCATTTCGGAGGACGACATACGCAAACAGGAGGATAGGGTCGGAGTGGCGCGGCGAAAGCTGCAGGATGCACTCAAGACATGA
- Protein Sequence
- MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANSNASSNNNSSSATASSNNNNNKVDVFYYSSPTGKRAEGKPQDIAIPDFQSGKMPHRALPSPSISLYRCSAMPLPIASGGGNGATSGSAANALKRKFARSQGGNAAAAAGGAAPSTATASSAASASASPSTANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTVIRNHKQDPAKAKNDPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKVDLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00515588; iTF_00578532; iTF_00543112; iTF_00619145; iTF_00504682; iTF_00591692; iTF_00548058;
- 90% Identity
- iTF_00548058;
- 80% Identity
- -