Dpro011085.1
Basic Information
- Insect
- Drosophila prostipennis
- Gene Symbol
- MBD2
- Assembly
- GCA_037075205.1
- Location
- JBAMCJ010004657.1:405451-407038[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 2.4e-20 7.2e-17 61.0 0.0 1 58 9 87 9 105 0.92 2 2 1.8e-06 0.0055 16.5 0.0 27 76 181 241 129 242 0.85
Sequence Information
- Coding Sequence
- ATGCAAATGAACCCGAGCGTCACAATCGAGCGCAAACGCGTCGACTGCAGTGTCCTGCCCAAAGGATGGCAGCGCGACGAGGTCCGCAAGTCGGGCAGCAGCTCCAATAGCaacgccagcagcaacaacaacaacagcagcagtgccacagccagcagcaacaacaacaataacaaggtGGATGTTTTCTACTACAGTCCCACAGGAAAAAGGGCGGAGGGAAGGCAGCAGGACATTGCAGTCCCCGATTACCAACCCGGCAAGATGCAGCAACGGGCCCTGCCCTCGCCATCCATTTCGCTGTACCGCTGCAGCGCCATGCCCCTGCCCCTGACAAGTGGCGGTGGAAATGGGGCCACCACCGGATCGGCGGCCAATGCCCTCAAGCGCAAGTTCGCCCGGAGTCAAGGAGgctctgcagcagcagcagcagcagcggtggGAGGAGCTGCTCCTCCGGCAGTGGTCGcctcatcagcagcagcatcatctGCATCACCATCATCGGCCAatcggcagcagcaacagattGAACTCAGCCGAGCCCTGCGCACAGATGTCTCCCTGGTGCCGCCCATCCGACAGACTGCCTCGATCTTCAAGCAACCGGTGACGGCGATCCGCAACCACAGCCAGGATCCTGCCAAGGTGAAGCCTGATGCCAAGCATGGCACCCGGGAGAAGCCTAAGCAGCTGTTCTGGGAGAAGCGGCTGGAACGACTACGCGCCTGCCACGACAGCGGCGAGGAGCTGGACGACATCTCACTGCCCAAGACCATACGCACCGTTGGCCCCAATGTCAATGAACAGACCGTCCTCCAGTCGGTGGCCACGGCGCTGCACATGCTCAACGCCGGTGTCCACGGCCAGAGTTCCACGAAGGCTGACTTGACCAAGAATGCGATGGCGTTCATGAATCCCGAACAGCCGCTCATGCACGCGGTGATCATTTCCGAGGACGACATTCGCAAGCAGGAGGACCGGGTCGGTGTGGCGCGGCGAAAGCTGCAGGATGCACTCAAGACATGA
- Protein Sequence
- MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSSNSNASSNNNNSSSATASSNNNNNKVDVFYYSPTGKRAEGRQQDIAVPDYQPGKMQQRALPSPSISLYRCSAMPLPLTSGGGNGATTGSAANALKRKFARSQGGSAAAAAAAVGGAAPPAVVASSAAASSASPSSANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTAIRNHSQDPAKVKPDAKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00592385;
- 90% Identity
- iTF_00548058;
- 80% Identity
- -