Basic Information

Gene Symbol
MBD2
Assembly
GCA_000001215.4
Location
JANZWZ010000930.1:120223-121793[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 1e-15 5.7e-12 45.4 0.0 1 41 9 69 9 82 0.95
2 2 0.0024 13 5.8 0.0 42 76 172 217 171 218 0.92

Sequence Information

Coding Sequence
ATGCAAATGAACCCGAGCGTCACAATCGAGCGCAAACGCGTCGACTgcagtgtcctgccaaagggatggcagcgcgacgaggtccgaaagtccggcagcagcgccaataacaacgccagcagcaacaacaacagcagtgccacagccagcagcaacaacaacaataacaaggtggatgttttctactacagCAGTCCCACAGGAAAAGGGCGGAGGGAAAGCCGCAGGACATTGCAATCCCTGATTTCCAGCCTGGCAAAATGCCGCACTGCGCCCTGCCCTCGCCCTCCATTTCGCTGGGGCGGTAATGGGGCCACCAGCGGATCGGCGGCCAATGCCCTCAAGCGCAAGTTCGCCCGGAGTCAAGGAGGCAATgctgcaggagcagcaggagctgctcctccggcagcgaccgcctcgtcagcagcaacagcgacagcagcatctgcttcaccatcaacggccaatcgccagcagcaacagATCGAACTCAGCCGAGCCCTGCGCACTGATACTGCCTCGATCTTCAAGCAACCGGTGACGGTGATTCGCAACCATAAACAGGATCCCGCCAAAGCGAAGAATGAACCCAAGCATGGCACTCGGGAGAAGCCGAAACAGCTGTTCTGGGAGAAGCGACTGGAACGACTACGCGCCTGCCACGACAGTGGCGAGGAGCTAGACGACATCTCACTGCCCAAGACCATACGCACCGTTGGCCCCAATGTCAACGAACAGACCGTCCTCCAGTCGGTGGCCACGGCCCTGCATATGCTCAACGCCGGCGTACACGGCCAGAGTTCTACGAAGGCTGATTTGACCAAGAATGCCATGGCGTTTATGAATCCTGAACAACCGCTCATGCACGCGGTGATCATTTCGGAGGACGACATACGCAAACAGGAGGATCGGGTCGGAGTTGCGCGGCGAAAGCTGCAGGATGCACTCAAGACATGA
Protein Sequence
MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANNNASSNNNSSATASSNNNNNKVDVFYYSSPTGKGRRESRRTLQSLISSLAKCRTAPCPRPPFRWGGNGATSGSAANALKRKFARSQGGNAAGAAGAAPPAATASSAATATAASASPSTANRQQQQIELSRALRTDTASIFKQPVTVIRNHKQDPAKAKNEPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKADLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00592385;
90% Identity
-
80% Identity
-