Basic Information

Gene Symbol
MBD2
Assembly
GCA_016746365.1
Location
NC:11197130-11198902[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.6e-19 5.2e-16 58.4 0.0 1 58 9 87 9 105 0.91
2 2 3.7e-07 0.00074 19.5 0.0 27 76 179 239 129 240 0.88

Sequence Information

Coding Sequence
ATGCAAATGAACCCGAGCGTCACAATCGAGCGCAAACGCGTCGACTGCAGTGTCCTGCCAAAGGGATGGCAACGCGACGAGGTCCGAAAATCCGGCAGCAGCGCCAATAGCaacgccagcagcaacaacaacagcagcagtgccacagccagcagcaacaacaacaataataaggTGGATGTTTTCTACTACAGCAGTCCCACAGGAAAAAGGGCGGAGGGGAAGCCGCAGGACATTGCAATCCCCGATTTCCAGTCTGGCAAGATGCCACACCGAGCCCTGCCCTCGCCCTCCATTTCGCTGTACCGCTGCAGCGCCATGCCGCTGCCCATAGCCAGCGGGGGTGGTAATGGGGCCACCACTGGATCGGCGGCCAATGCCCTCAAGCGCAAGTTCGCCCGGAGCCAAGGAGGCAAcgctgctgcagcaggaggagctgctccTCCGGCAGCGGCCGCCTcgtcagcagcaacagcagcagcatctgcttCACCATCAACTGCCAatcgccagcagcaacagatcGAACTCAGCCGAGCCCTGCGCACAGATGTCTCCCTGGTACCGCCAATCCGACAGACTGCCTCGATCTTCAAGCAACCGGTGACAGTGATTCGCAACCACAAACAGGATCCCGCCAAAGCAAAGAATGATCCCAAGCATGGCACTCGGGAGAAGCCGAAGCAATTGTTCTGGGAAAAGCGGCTGGAACGACTCCGCGCCTGCCACGACAGCGGCGAGGAGCTAGACGACATCTCACTGCCCAAGACCATACGCACAGTTGGCCCCAATGTTAACGAACAGACCGTCCTCCAGTCGGTGGCCACGGCCCTGCATATGCTCAACGCCGGCGTTCACGGCCAGAGTTCTACGAAGTCTGATTTGACTAAGAATGCCATGGCGTTCATGAATCCTGAACAGCCGCTCATGCACGCGGTTATCATTTCGGAGGACGACATTCGCAAGCAGGAGGATAGAGTCGGTGTGGCGCGGCGAAAGCTGCAGGATGCACTCAAAACATGA
Protein Sequence
MQMNPSVTIERKRVDCSVLPKGWQRDEVRKSGSSANSNASSNNNSSSATASSNNNNNKVDVFYYSSPTGKRAEGKPQDIAIPDFQSGKMPHRALPSPSISLYRCSAMPLPIASGGGNGATTGSAANALKRKFARSQGGNAAAAGGAAPPAAAASSAATAAASASPSTANRQQQQIELSRALRTDVSLVPPIRQTASIFKQPVTVIRNHKQDPAKAKNDPKHGTREKPKQLFWEKRLERLRACHDSGEELDDISLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKSDLTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00592385;
90% Identity
iTF_00548058;
80% Identity
iTF_00591692;