Drob006721.1
Basic Information
- Insect
- Drosophila robusta
- Gene Symbol
- br
- Assembly
- GCA_004143805.1
- Location
- SCDV01008993.1:655-1290[+]
Transcription Factor Domain
- TF Family
- BTB
- Domain
- zf-C2H2|ZBTB
- PFAM
- PF00651
- TF Group
- Zinc-Coordinating Group
- Description
- The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 3.1e-22 1.4e-19 70.9 0.1 1 83 25 104 25 105 0.93
Sequence Information
- Coding Sequence
- atggctgccGTGCGGGGTCATCAGTACTTTAGTCTCCGCTGGAATAACTATCAAAACACGATGACGTCAGTGTTTCAGCAGCTACGCGAGGATCTCTCCTTTGTCGATGTGACCTTGTCCTGTGAGCATGGCTCGCTCAAGGCGCACAAGGTTGTCTTATCCGCCTGCTCAACATATTTCCAAAAGCTGCTGCTCGAGAATCCTTGCAAGCATCCAACGATCATATTACCCGCCGACATCATATTCACAGATCTAAAAACaattatcgattttgtttATCGCGGCGAAATCGATGTTACCGAATCGGACTTACAGG
- Protein Sequence
- MAAVRGHQYFSLRWNNYQNTMTSVFQQLREDLSFVDVTLSCEHGSLKAHKVVLSACSTYFQKLLLENPCKHPTIILPADIIFTDLKTIIDFVYRGEIDVTESDLQ
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00558819;
- 90% Identity
- iTF_00749079;
- 80% Identity
- iTF_00537607; iTF_00598253; iTF_00556602; iTF_01327261; iTF_00901598; iTF_01356226; iTF_00805284; iTF_00575685; iTF_00516360; iTF_00553800; iTF_01554056; iTF_00595337; iTF_00614282; iTF_00832266; iTF_00586059; iTF_01559851; iTF_01555501; iTF_01556924; iTF_00482348; iTF_01324236; iTF_01553324; iTF_01551821; iTF_00475311; iTF_00531048; iTF_00574159; iTF_00558819; iTF_00538321; iTF_01551089; iTF_01557650; iTF_00495955; iTF_01326515; iTF_00511380; iTF_00520724; iTF_00508437; iTF_00532469; iTF_01558389; iTF_00566902; iTF_00572694; iTF_01327990; iTF_01548950; iTF_00547447; iTF_00506969; iTF_00541849; iTF_01556217; iTF_00514266; iTF_00568346; iTF_01325018; iTF_00901595; iTF_00558012; iTF_01322748; iTF_01549660; iTF_00528902; iTF_00608541; iTF_00546750; iTF_01323486; iTF_00559583; iTF_00577151;