Dleo004954.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila leonis
Gene Symbol
ftz-f1
Assembly
GCA_035045365.1
Location
JAWNPC010000262.1:947588-958404[-]

Transcription Factor Domain

TF Family
SF-like
Domain
zf-C4|SF-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 2 2.1e+04 -7.3 19.5 41 160 26 150 7 163 0.44
2 3 9.8e-20 1e-15 58.3 0.1 1 80 322 400 322 453 0.79
3 3 1.4e-72 1.4e-68 232.4 0.4 156 408 520 765 475 767 0.91

Sequence Information

Coding Sequence
atgttaTTAGAAATGGATCCCCAACAGGCGACTGTACAGTTTATATCGTCGCTGAATCTGTCACCGTTTAGCATGCAGCTTGATCAACAGCAGCCAGCGAGTCCCGCGCAGAgtaacaccaacaacaataatagcagcggcagcggcaacaaccacacgaacaacaacaataataataatagtagcaATGATAACGATACAAATCCTTTAAGCAATTCCGATAACGATTACAGCGCCTACACGCTGCAGTTGGGcaatcatcaacagcagcagccgcagcagcaacagcaccataATACgcatcatcagcaacaacaacaacatactCATTaccaactgcaacaacaacagaataTTGCCAGCAACAATGCGAATGCTGCAGCGAACCAATTCAATGCCTCCTCTTAttcgtatatatacaatttcgattcaCAGTATATATTTCCGACAGGCTATCAGGAAACCAATTCGTCCCATTCGCAGCAAAGCGGCAACGGCGCCGGCGTAGCTTCTGGTAACTCTGGCCAGCTACTAAACGGTGGCAGCAACAGTATAGCAGGCAACGGGTATATGTTGCTGCCACCAGGTGTCACATCAGCTGCTCACATGTCCGGCAATGTGGGTGGCAGCGGAGCTGCAGGTGGTGCTGGCAATGTTCTCTCAactggcggtggtggcggtggtctTCATGGTGGAACAAGCGCCACCTCTGGCGGAGGCGAAGCCATCGACTTCAAGCACTTGTTCGAGGAGCTGTGCCCCGTCTGTGGCGATAAGGTGAGCGGCTATCACTACGGCCTGCTCACCTGCGAGTCCTGCAAGGGCTTCTTCAAGCGGACcgttcaaaataaaaaggtCTACACATGCGTCGCGGAACGCTCCTGCCACATCGATAAAACGCAGCGGAAACGTTGTCCATACTGCCGATTCCAAAAGTGCCTCGAAGTGGGCATGAAACTCGAAGCGGTTCGAGCAGATCGTATGCGTGGTGGCCGTAACAAATTTGGACCCATGTACAAAAGGGATCGAGCGCGCAAGCTGCAGGTGATGCGCCAACGGCAACTTGCTCTGCAGGCGCTACGGAGTTCTATAGGTTCAGATATAAAGCCGACGCCGCTCTCACCTGGCTATCAGCAAGCATAtccaaatatgaatattaagcAAGAAATTCAAATACCTCAGGTATCCTCACTCACGCAATCGCCGGATTCATCACCCAGCcccattgccattgctttGGGCCAGGTGAATGTTGGCGTTGGCGGTGTGATAGCCACGCCCCTAAATGTTGGCAATTTGAGTGGCGGCAGTTCGCtaggcaatggcaacagcaacactaataacaacagcagcacaggAAGCGGCAGCGGGGGTAGTGGCGGTGGCAATAACGCTGGCGGCGGTAGCGGtgccaccaacagcaacaacatcccTGATGGCCTGCAACGTAACGGAAACAgtggcaatagcaacagcaacagcagctgccatgAAACCGGGAATGGATCTCTGCAGAACACAGCTGAATCGAAATTGTGcttCGATTCTGGCACACATCCATCGAGCACAGGGGATTCACTCATTGAACCGCTGAGGGTCTCGCCGATGATACGTGAGTTTGTACAATCGATCGATGATCGGGAATGGCAGACTCAGCTTTTTGCGCTGCTGCAGAAGCAGACTTATAACCAAGTTGAAGTTGATCTCTTTGAGTTAATGTGCAAAGTCTTGGATCAAAATCTGTTCTCACAAGTGGATTGGGCAAGAAACACTGTCTTTTTTAAGGATTTAAAGGTGGATGATCAGATGAAGCTGCTTCAGCATTCTTGGTCGGACATGCTTGTGCTGGATCATCTGCACCATCGTATACACAACGGTTTGCCGGATGAGACGCAGCTGAATAATGGGCAGGTGTTTAACTTAATGAGCCTTGGCCTATTGGGAGTACCACAGTTGGGTGACTACTTTAATGAGTTGCAAAACAAGCTACAGGACCTGAAGTTCGATATGGGAGACTATGTGTGCATGAAATTCCTAATACTTTTAAATCCAGATGTACGTGGAATAGTGAACAAAAAGACCGTTGTGGAGGGACACGAGAATGTTCAGGCAGCTCTGCTGGATTACACACTTACGTGTTACCCCTCAGTAAATGACAAATTTAGGAGGCTTTTGAATATACTACCGGAAATACACGCCATGGCCGCGCGCGGCGAAGAACATCTATACTCAAAACATTGTGCGGGCAGTGCACCCACACAGACGCTGCTCATGGAGATGTTGCATGCTAAACGAAAGGTGTGA
Protein Sequence
MLLEMDPQQATVQFISSLNLSPFSMQLDQQQPASPAQSNTNNNNSSGSGNNHTNNNNNNNSSNDNDTNPLSNSDNDYSAYTLQLGNHQQQQPQQQQHHNTHHQQQQQHTHYQLQQQQNIASNNANAAANQFNASSYSYIYNFDSQYIFPTGYQETNSSHSQQSGNGAGVASGNSGQLLNGGSNSIAGNGYMLLPPGVTSAAHMSGNVGGSGAAGGAGNVLSTGGGGGGLHGGTSATSGGGEAIDFKHLFEELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNKKVYTCVAERSCHIDKTQRKRCPYCRFQKCLEVGMKLEAVRADRMRGGRNKFGPMYKRDRARKLQVMRQRQLALQALRSSIGSDIKPTPLSPGYQQAYPNMNIKQEIQIPQVSSLTQSPDSSPSPIAIALGQVNVGVGGVIATPLNVGNLSGGSSLGNGNSNTNNNSSTGSGSGGSGGGNNAGGGSGATNSNNIPDGLQRNGNSGNSNSNSSCHETGNGSLQNTAESKLCFDSGTHPSSTGDSLIEPLRVSPMIREFVQSIDDREWQTQLFALLQKQTYNQVEVDLFELMCKVLDQNLFSQVDWARNTVFFKDLKVDDQMKLLQHSWSDMLVLDHLHHRIHNGLPDETQLNNGQVFNLMSLGLLGVPQLGDYFNELQNKLQDLKFDMGDYVCMKFLILLNPDVRGIVNKKTVVEGHENVQAALLDYTLTCYPSVNDKFRRLLNILPEIHAMAARGEEHLYSKHCAGSAPTQTLLMEMLHAKRKV