SF-like


Domain
zf-C4|SF-like
Group
Zinc-Coordinating Group
PFAM
AnimalTFDB
Desciption
The ligand binding domain of nuclear receptor steroidogenic factor 1 (SF-1): SF-1, a member of the nuclear hormone receptor superfamily, is an essential regulator of endocrine development and function and is considered a master regulator of reproduction. Most nuclear receptors function as homodimer or heterodimers, however SF-1 binds to its target genes as a monomer, recognizing the variations of the DNA sequence motif, T/CCA AGGTCA. SF-1 functions cooperatively with other transcription factors to modulate gene expression. Phospholipids have been determined as potential ligands of SF-1. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, SF-1 has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [1, 8, 3, 11, 6, 5, 12, 10, 9, 2, 4, 7]
Rederence
  • Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay JA, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. Cell 120, 343-55, (2005).
  • Ligand binding and nuclear receptor evolution. Escriva H, Delaunay F, Laudet V. Bioessays 22, 717-27, (2000).
  • Steroidogenic factor 1 plays multiple roles in endocrine development and function. Wong M, Ikeda Y, Luo X, Caron KM, Weber TJ, Swain A, Schimmer BP, Parker KL. Recent Prog Horm Res 52, 167-82; discussion 182-4, (1997).
  • Origins and evolutionary diversification of the nuclear receptor superfamily. Owen GI, Zelent A. Cell. Mol. Life Sci. 57, 809-27, (2000).
  • Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. Ortlund EA, Lee Y, Solomon IH, Hager JM, Safi R, Choi Y, Guan Z, Tripathy A, Raetz CR, McDonnell DP, Moore DD, Redinbo MR. Nat. Struct. Mol. Biol. 12, 357-63, (2005).
  • The nuclear receptor SF-1 (steroidogenic factor-1) is no longer an orphan. Bertherat J. Eur J Endocrinol 138, 32-3, (1998).
  • Principles for modulation of the nuclear receptor superfamily. Gronemeyer H, Gustafsson JA, Laudet V. Nat Rev Drug Discov 3, 950-64, (2004).
  • Steroidogenic factor-1: its role in endocrine organ development and differentiation. Hammer GD, Ingraham HA. Front Neuroendocrinol 20, 199-223, (1999).
  • The evolution of the nuclear receptor superfamily. Escriva H, Bertrand S, Laudet V. Essays Biochem. 40, 11-26, (2004).
  • Differential expression of steroidogenic factor-1 and FTF/LRH-1 in the rodent ovary. Falender AE, Lanz R, Malenfant D, Belanger L, Richards JS. Endocrinology 144, 3598-610, (2003).
  • Of mice and men: The tale of steroidogenic factor-1. Jameson JL. J Clin Endocrinol Metab 89, 5927-9, (2004).
  • LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis. Fayard E, Auwerx J, Schoonjans K. Trends Cell Biol. 14, 250-60, (2004).
Statistic of Transcription Factors
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Transcription Factors Table

Statistic of Transcription Factors




Transcription Factor Table

Species

Gene ID Insect Gene Name Gene Symbol
iTF_00000395 Abrostola tripartita Atri019999.1 Hr39
iTF_00000396 Abrostola tripartita Atri003837.1 FTZ-F1