Basic Information

Insect: Drosophila hydei
Gene Symbol: MBD-R2_1
Assembly: GCA_003285905.2
Location: NW:5344207-5348639[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 7.8e-23 2e-19 68.5 0.1 4 76 449 519 446 520 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	7.8e-23	2e-19	68.5	0.1	4	76	449	519	446	520	0.93

Sequence Information

Coding Sequence: ATGGGGCGCCGCTGCTGCGTTGCTGAATGCCCCTCTACGTCGCGTCTCTTTGAGCACCATGGCGTGACCTACCACTCATTCCCGATGGACGCCGTCATTCGTGCCATTTGGATCAAGAACTCCCGCATAAGTCTGGACCGGCAAATCACAAAAAGTGTGCTTGTATGCTCACGTCATTTTCGACGCCTCGACTTTAATACTATACGCAATGGAAAGTACTTGTTGAAGCCGCGCGTCTTTCCCACTGTATTTCCGTGGGGTAAGATGGAGCCCGCTGAGATAGAGGCTGATCATCGGGCCTTGCAACAGGCGACGGTGGATGGTGCTGGTGTAAGCGGTGCCGCGAACAGCGCCAATAACGAAGACGTCATTAAGGCAACTGTTGACCAGATTGTTGCCCAAATATTAGCAGAGACAGCGGAACGTaatgctgcagcggctgcagcagcagaggctgCCGCTAaggctgaagctgaagcagagTCTGAAGGCAGTCAAAAAGAATCAGCAAAGGAAGCCGCCGTCGACACCGCTGTTGTTGCGCCATCTACAGAGAGCACAGCTGTTGTATCCGAGGTAACAACCGCTTCAACTGATTCGGCCAATGAAACAGTTATTGCTGCCAGCAACGCGTCTTCGCCCCTTTCAAATACGCCACCGAAATACGGCTCACCCACAAACCTGACAATTGGAGCTCGTCTAGAGGCGTTGAGCGTCGATGGCGCTTGGCTGCCAGCACGCATTGTCGAAGTTAATGAAACGGAGCAAACGCTACTGATACGATTCGAACGCAACAACAAGCTAAAGGTATCACCGTCGACAAGCGGCAGCTATCAAGAATGGATCGCCTTTAAATCGGACCGCTTACGACAGCGTATCAGTTCGCGGGTTCTTCCCATTTTCGAGCTGGAGGAGAAGTGCATGGCGCGCTGGTCGGGACCTCGAAAATTTCCGGGAACCATCAAAAAGCTTCTGGGCAATGACACTTATGAGGTGCTATTCGATGATGGGTACACAAAGAATGTTCGTGCAGTGCACATGAATAAATTGCCACGCCAACTCTCGGCCAACATAGAACCAGATGTTGAGACGCAATCAACAGACTCTGCTTCAGCTACAGTTACTGTAAAAAGGCCCAGTACTAGTGCCtctagcagcaacaagaaagcCAAGGTGACTCCTCAACGCAAGGACTGGCCACTGCTAGACATGTCTAATTTGGACTTGGCGGCTTTGGGATTGCCGGAAATACCACTTGATGGGGAATGGACATGCCATTGGGTGAATGATCAGCCAATTGGCTCAGAAGGTTTTCTGATTGTCGGCGAGCACCAGAAGCCGACGGTCATTGTGAACGACTGGCGATTGCCGCCTGGTTGGATCAAACATATGTACCAACGCTCAAATGTGCTCGGAAAATGGGATGTCATTTTAGTGTCGCCCAGCGGCAAACGTTTTCGCTCCAAATCTGATTTAAAGGCGTTTTTGGAGTCACAGGGTCTGGTCTATAATCCGGATGTGTACGATTTTAGTATTCATCGCCGGCGAGCGAAAGACATTAATGCCTACGTCTATACGCATGACTACAGTCCACAACAGCCAGCAAAGCCGAAGCCAATGGACGTGTCCCTGGACACATCAAAAACAGAGTCACAGGAacttagcaacaacaagctaTCGACAGCTGCGTCCTCATCAACGCCTATATCACCATTGAGCACACGTCGTGGGGCAGGCGAGGACAGTCAGTATATGGAAACACCGGTTGCCTCGCTGATACCTCCTGCGGAATTGATGTCACCGTCGCCACGTGCCCCAGATAATGAAGCACCGGCTCATGCAGCTGAATCAGTCGATGCAACCCCTGTGCTACCCGTCGATGAGCAAGGCACCTTACTTGAAGACGGTTACGTATTTATTGGCGGATTGAAGGTACAGATAACCGataatttgtttgtgtgccCCAGTGAAGGCTGCGGTAAAACTTGCCGCAAAGAGGACTTTCTGCAAATACACATACGACATTATCATAAGGAACTAGCACAacaCTTCAGTCACTGCCCGAAGATGCAGGAACTGGCTGTTAAACGCACTCATCCGTCTTCGATTGAACAGAATGATCAGACGCCGAAGAATCAAATACCGAATCAACAGTTCTTTAATAAGATGCACCAACAAGATTTACAGCAATCCCGATCCTTTCGACGTCAACCAGCTGTTACGGAAACATCGCCAACAATTCGTGACGGCTCGCCAATTGTTTCGCCTAGCAACCGGTTGTCATCGCCTAAAACGGAGACGCCAACGACACCAAAAAGTACGCCACAACCAACAAGTGGCACTCCGGAAGCTGCTGCAAATGTTGTACCTCCACCGAATGTAGACGTTTCGCCTCTTCCAGCAGCACTGGAGTCGACTAAAGTGACTACACCAGTCGCAACAAACCGCTCCGCCAAACGTTCGCGTCCATCATCCAGCAAGCGCTCGTCTGGCTCCCGTAAAAGCAGCCGACAACGCACACAACGTCGTTATGCAAATGTCGCGCATGACAATATGCCTACGGCAAATACTGCGCTTAACTCACCAGCCTCTGGAGGAGATTACGAAGATACCCGACAGTCGTTTACTACGCCCACACCAGATGTTCGTAATGATGCCAAGAAACGCCGTGTAGCTCTCTCTGGAACGCCGGCTAGCTCGCCTATAATCGATGCTATGTCAACACCATCCTCTAACGATCTGGTGGATATAAATGCAGCATTGGCGCCACCGCCGCCCCAGTTGACCAGCCATACGCCACAGTACATTAAGGAGAACGGCGAGTTAATACGTATAGTGCGCATGAGGCAGGAAGAAatcataaattgcatttgtgaaTATGGCGAAGAGGATGGTCTCATGATACAATGTGAACTATGCCTTTGTTGGCAGCATGGTGCTTGTAATGGCATTGTTAAAGAATCGGACGTACCGGATAAATATGTCTGCTACATTTGCCGCAATCCGCAGCGAGTACGCGAATCGATGCGTTTCAAGCATGATCAGGACTGGCTTTTCGAAGGCAAACTGCCTGTTGCTGGGTATCATACGCCGAACCCTCAGACATCTAAGAAGTTCGAGTTGTTAAAACGGTCACACACGCTTACGGGCAATTTGCTAGATGCTAAGCGTTCCATGCATTCTCTGTTagtaaaaatcaatattgCTCGCAATCGTTACCACCCCAAACTATATCTGTGGGCCAAGAAGTGGGACGAAGATCAGGCTGAGAACTCAACCACTCCTGTCAAGCGTCCAAAGGCCGAACAGCCAGACTGGCCGCATGTGCCGCAACCGGAAGCTGCAATCGACCCAGAAGAGTGCCAATACCGTTTAATAGAACACGTTAAGATACAGCAGTCGTTGTTAATGAATCGTCTTAATGAGATCGAAGGAGAAATGGATGAGCTGGAAAAGGAAGACACCTTGCCCGATTTAAAAGATGCAAATATGTCAACAACGAAAGAGGCCATGGCAACGTTTATAAAGGAGCTGGAAACATTAAAACGTCTTGCTAATCTTAACAAGGTGGCTAATATGAAGCAAGCATTAAAGAATCAAGAACCGTCAACCGATGTTGCGCAAGCGTGA
Protein Sequence: MGRRCCVAECPSTSRLFEHHGVTYHSFPMDAVIRAIWIKNSRISLDRQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMEPAEIEADHRALQQATVDGAGVSGAANSANNEDVIKATVDQIVAQILAETAERNAAAAAAAEAAAKAEAEAESEGSQKESAKEAAVDTAVVAPSTESTAVVSEVTTASTDSANETVIAASNASSPLSNTPPKYGSPTNLTIGARLEALSVDGAWLPARIVEVNETEQTLLIRFERNNKLKVSPSTSGSYQEWIAFKSDRLRQRISSRVLPIFELEEKCMARWSGPRKFPGTIKKLLGNDTYEVLFDDGYTKNVRAVHMNKLPRQLSANIEPDVETQSTDSASATVTVKRPSTSASSSNKKAKVTPQRKDWPLLDMSNLDLAALGLPEIPLDGEWTCHWVNDQPIGSEGFLIVGEHQKPTVIVNDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKAFLESQGLVYNPDVYDFSIHRRRAKDINAYVYTHDYSPQQPAKPKPMDVSLDTSKTESQELSNNKLSTAASSSTPISPLSTRRGAGEDSQYMETPVASLIPPAELMSPSPRAPDNEAPAHAAESVDATPVLPVDEQGTLLEDGYVFIGGLKVQITDNLFVCPSEGCGKTCRKEDFLQIHIRHYHKELAQHFSHCPKMQELAVKRTHPSSIEQNDQTPKNQIPNQQFFNKMHQQDLQQSRSFRRQPAVTETSPTIRDGSPIVSPSNRLSSPKTETPTTPKSTPQPTSGTPEAAANVVPPPNVDVSPLPAALESTKVTTPVATNRSAKRSRPSSSKRSSGSRKSSRQRTQRRYANVAHDNMPTANTALNSPASGGDYEDTRQSFTTPTPDVRNDAKKRRVALSGTPASSPIIDAMSTPSSNDLVDINAALAPPPPQLTSHTPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKESDVPDKYVCYICRNPQRVRESMRFKHDQDWLFEGKLPVAGYHTPNPQTSKKFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRYHPKLYLWAKKWDEDQAENSTTPVKRPKAEQPDWPHVPQPEAAIDPEECQYRLIEHVKIQQSLLMNRLNEIEGEMDELEKEDTLPDLKDANMSTTKEAMATFIKELETLKRLANLNKVANMKQALKNQEPSTDVAQA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00519956; iTF_00502517; iTF_00502560; iTF_00598145; iTF_00588838; iTF_00588880; iTF_00598193; iTF_00547350; iTF_00547394; iTF_00545282; iTF_00544484; iTF_00545231; iTF_00544531; iTF_00541798; iTF_00567530; iTF_00567574; iTF_00541754; iTF_00530945; iTF_00530988; iTF_00490772; iTF_00490815; iTF_00563210; iTF_00563169; iTF_00550929; iTF_00550888; iTF_00475251; iTF_00475209; iTF_00561075; iTF_00561030; iTF_00506102; iTF_00506146; iTF_00526615; iTF_00526568; iTF_00616895; iTF_00616939; iTF_00549545; iTF_00473099; iTF_00549585; iTF_00479477; iTF_00479516; iTF_00473056; iTF_00493642; iTF_00599624; iTF_00493688; iTF_00599579; iTF_00540405; iTF_00540361; iTF_00532410; iTF_00532363; iTF_00551580; iTF_00551623; iTF_00554419; iTF_00554378; iTF_00568243; iTF_00568289; iTF_00582291; iTF_00582249; iTF_00476662; iTF_00476617; iTF_00512758; iTF_00512713; iTF_00546647; iTF_00546692; iTF_00495896; iTF_00495853; iTF_00534616; iTF_00534571; iTF_00559480; iTF_00559524; iTF_00586714; iTF_00586668; iTF_00509852; iTF_00509808; iTF_00530301; iTF_00530258; iTF_00572637; iTF_00572591; iTF_00573309; iTF_00573356; iTF_00516254; iTF_00516301;
90% Identity: iTF_00502560;
80% Identity: iTF_00519956;