Dmet003227.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila mettleri
Gene Symbol
MBD-R2
Assembly
GCA_035047625.1
Location
JAWNPI010000035.1:12243324-12247454[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.8e-22 5.5e-19 67.5 0.1 3 76 451 522 449 523 0.93

Sequence Information

Coding Sequence
ATGGGGCGCCGGTGCTGCGTTGCTGAATGTCCCTCAACATCGCGACTCTTTGAGCATCATGGCGTGACCTACCACTCATTTCCGATGGACGCCGTCATTCGTGCGATTTGGATCAAAAATTCGCGCATAAGTCTCGACCGACAAATTACAAagagtgtgcttgtgtgctCACGTCATTTTCGGCGTCTTGACTTTAATACTATACGCAATGGAAAGTACTTGTTGAAACCACGCGTCTTCCCTACCGTCTTTCCGTGGGGAAAAATGGAGCCCGCTGAGATAGAGGCTGATCATCGGGCTTTGCAACAGGCGACTGTGGATAGCTCTGGGGCGAACGGTTCCGCTAACAGCGCTAGTAACGAAGACGTTATCAAAGCAACTGTTGACCAAATTGTTGCCCAAATATTAGCAGAGACAGCTGAGCgcaatgctgcagcagctgcagcagctactgCTGCAGAGGAAGCCGCTAAAGCCCAATCTGAAGCCACCTCTGAAGGAAGCCAAAAAGAAGCAGTTAAAGATGAACCTGCGGAAACCTCAGTTGATGTGCCATCTGCAGATAGCACAGCTGTCGTCTCCTCCACTGAGGTGACAACCACTTCAACAGATTCTTCCAATGAAGCAGCGCCTGTTGCAAGCAGCGCCTCTTCCCCACTTTCTAATACGCCATCGAAGTACGGCTTACCTACAAACCTAACAATTGGAGCTCGTCTAGAGGCGTTGAGCGTTGATGAGGTTTGGCTACCAGCACGCATTGTCGAAGTCAACGAAACCGAGCAGACACTGCTTATACGATTTGAGCGCAACAGCAAGCTAAAGATATCACCGTCCACAAGCGGCAGCTACCAAGAGTGGATTCCATTCAAATCGGAGCGCTTGCGGCAGCGTATCAGCTCGCGCGTGTTACCTATTTTTGAGCTGGAGGAGAAATGCATGGCGCGCTGGTCGGGACCACGGAAATTCCCGGGCACCATCAAAAAGCTGCTGGGCAATGACACATACGAGGTTCTATTCGATGATGGATACACAAAGAATGTTCGTGCAGTGCACATGAACAAATTGCCGCGTCAGCTGTCAGCCAGCATAGAACTGGATGCTGACACGCATTCAACAGATTCTGCAACAGGCGGTATAAAACGGCCCAGCACTGGCTccgcgagcagcagcaagaaactTAAGGTGACTCCTCAACGCAAGGACTGGCCCCTACTGGATATGTCCAACTTGGACTTAGCGGCTTTGGGCTTACCGGTAATACCACATGATGGAGAATGGACATGCCATTGGGTGAATGATCAACCAATTGGCACAGAAGGTTTCCTTATTGTCGGCGAGCACCAGAAGCCGACGGTGATTGTGCAGGACTGGCGTTTGCCGCCTGGTTGGATTAAACACATGTACCAACGCTCAAATGTGTTGGGAAAATGGGATGTGATTCTAGTCTCGCCCAGTGGCAAACGTTTTCGCTCCAAGTCCGATTTAAAGGTGTTTTTAGAATCCCAGGGTCTGGTCTATAATCCGGATGTGTACGACTTTAGCATTCATCGCCGGCGAGCCAAAGACATAAATGCTTACGTCTACACGCATGACTACAGTCCACAACAGCCACCGAAGCCTAAGATAATGGACGTGTCTCTGGACACCACAGCACCAGACTTACAGGAACAAAATAAGAGCAAGCTATCCGCAGCTACGTCTTCAACAACGCCCATATCACCGATGGCGGCTCGCCGTGGGGCGGGCGAGGACAGTCAGTATATGGAAACACCAGTGGCCTCGCTGATGCCTCCTGCGGAATTGATGTCACCATCGCCACGTAACCCAGATAATGAGGAACTGCCCGTTGCCCCTGCATCAGTCGATGCCACTTCTGCGCTTGCCGTGGATGAGCAAGGCACCGTGCTGGAAGATGGTTTCGTATTTATTGGAGGATTAAAGGTACAGATAACCgataatttatttgtgtgccCCAGCGAAGGATGCGGTAAGACGTGTCGCAAAGAGGACTTTCTGCAAATTCACATACGCCACTATCATAAGGAATTAGCACAGCACTTCAGCCACTGTCCCAAGATGCAGGAGCTGGCTGTTAAACGCACGCATCCGTCTTCAATTGACCAAAATGATCAGACGCCGAAAAACCAAATACCCAATCAACAGTTCTTTAGTAAGATGCATCAGCAAGACTTACAACAATCTCGCTCTTATCGGCGTCAGCCAGCTGGTTCGGAAACAACGCCATCAATACGTGACAGCTCGCCAACTGTTTCGCCTAGCACTCGGTTATTATCGCCTAAAACTGAGacgccaacgacaacaaaaagcaCGCCACCGGTAGCAAACAGCACTCCAGAAGCTGCTACTCCAGTAGCTGCACCTGTGGCGTTACCAGCGAATGTAGACTCTTCACCACCACATGCCACAGCAGAAGAGACGGCTAAACCTACTACACCACTCATCCCAAACCGCTCCGTCAAACGCGCTCGTCCTTCATCCAATAAGCGTACTTCTGGCTCTCGTAAAAGCAGCCGACAACGCACACAACGTCGCTATGCTAATGTCGCGCATGATAAAATGCCTAAGGCAACTAATGCTCACAACTCACCAGCTTCTGGAGTAGATTTCGAAGAAACCCGACAGTCGTTTACTACTCCCATACCAGATGCTCGTAATGATAACAAGAAGCGACGTGTGGCACTCTCTGGAGCTTCGGCTAGCTCGCCTATAATTGATTCCTTATCAACGCCAATGTCCAACGATCTGGTGGATATAAATGCAGCATTGGCTCCACCACCACAGCCACTGGCCAGTCACACGCCGCAGTACATTAAAGAGAACGGCGAGCTAATACGCATAGTTCGCATGAGGCAggaagaaattataaattgcatCTGTGAATATGGAGAAGAGGATGGATTGATGATCCAATGTGAGCTGTGCCTATGTTGGCAGCATGGTGCTTGCAACGGAATTGTTAAGGAATCGGATGTCCCGGATAAATACGTCTGCTACATTTGCCGAAATCCGCAGCGTGTGCGTGATTCAATGCGCTTCAAGCATGATCAGGACTGGCTCTTCGAGGGTAAATTGCCTGTGGCTGGGTATCATACACCGAATCCCCAGACATCTAAAAAGTTCGAGTTGCTGAAATGGTCTCACACACTGACGGGCAACTTGATAGATGCTAAACGTTCTATGCATTCCCTGTTAGTAAAGATTAATATTGCTCGTAATCGTTACCACCCTAAACTATATCTGTGGGCCAAAAAGTGGGACGAAGATCAGACCGAGGTCTCAACCACCCCTGTCAAGCGTCCAAAGGCTGAACAGTCGGACTGGCCGCACGTGCCGCAGCCGGAAGCTGCAATCGACCCAGAGGAGTGTCAACACCGTCTAATAGAACATGTTAAGATACAGCAATCGCTATTAATGAATCGACTTAGTGATATCGAAGGAGAAATGGATGAACTGGAAAAGGAAGATACCTTGCCCGATTTAAAGGATGCAAATATGTCAGCCACAAAGGAAGCCATGGCAACATTTATAAAAGAGCTGGAAATATTAAAACGTCTTGCTAATCTTAACAAGGTGACCAACATGAAGCAATCTATAAAGAATCAAGAACCATCAACCGATGTTGTCCAAGTGTag
Protein Sequence
MGRRCCVAECPSTSRLFEHHGVTYHSFPMDAVIRAIWIKNSRISLDRQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMEPAEIEADHRALQQATVDSSGANGSANSASNEDVIKATVDQIVAQILAETAERNAAAAAAATAAEEAAKAQSEATSEGSQKEAVKDEPAETSVDVPSADSTAVVSSTEVTTTSTDSSNEAAPVASSASSPLSNTPSKYGLPTNLTIGARLEALSVDEVWLPARIVEVNETEQTLLIRFERNSKLKISPSTSGSYQEWIPFKSERLRQRISSRVLPIFELEEKCMARWSGPRKFPGTIKKLLGNDTYEVLFDDGYTKNVRAVHMNKLPRQLSASIELDADTHSTDSATGGIKRPSTGSASSSKKLKVTPQRKDWPLLDMSNLDLAALGLPVIPHDGEWTCHWVNDQPIGTEGFLIVGEHQKPTVIVQDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKVFLESQGLVYNPDVYDFSIHRRRAKDINAYVYTHDYSPQQPPKPKIMDVSLDTTAPDLQEQNKSKLSAATSSTTPISPMAARRGAGEDSQYMETPVASLMPPAELMSPSPRNPDNEELPVAPASVDATSALAVDEQGTVLEDGFVFIGGLKVQITDNLFVCPSEGCGKTCRKEDFLQIHIRHYHKELAQHFSHCPKMQELAVKRTHPSSIDQNDQTPKNQIPNQQFFSKMHQQDLQQSRSYRRQPAGSETTPSIRDSSPTVSPSTRLLSPKTETPTTTKSTPPVANSTPEAATPVAAPVALPANVDSSPPHATAEETAKPTTPLIPNRSVKRARPSSNKRTSGSRKSSRQRTQRRYANVAHDKMPKATNAHNSPASGVDFEETRQSFTTPIPDARNDNKKRRVALSGASASSPIIDSLSTPMSNDLVDINAALAPPPQPLASHTPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKESDVPDKYVCYICRNPQRVRDSMRFKHDQDWLFEGKLPVAGYHTPNPQTSKKFELLKWSHTLTGNLIDAKRSMHSLLVKINIARNRYHPKLYLWAKKWDEDQTEVSTTPVKRPKAEQSDWPHVPQPEAAIDPEECQHRLIEHVKIQQSLLMNRLSDIEGEMDELEKEDTLPDLKDANMSATKEAMATFIKELEILKRLANLNKVTNMKQSIKNQEPSTDVVQV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00519916;
90% Identity
iTF_00546692;
80% Identity
iTF_00546692;