Basic Information

Insect: Drosophila robusta
Gene Symbol: MBD-R2
Assembly: GCA_004143805.1
Location: SCDV01000435.1:48775-54249[-]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.6e-22 7.3e-19 67.8 0.1 4 76 461 531 458 532 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.6e-22	7.3e-19	67.8	0.1	4	76	461	531	458	532	0.93

Sequence Information

Coding Sequence: ATGGGGCGTCGTTGCTGCGTTGCTGATTGCCCCTCCACGTCGCGTCTCATGGAACACCATGGCGTCACTTACCACTCGTTCCCGATGGACGCCGTCATACGTGCGATTTGGATTAAGAACTCGCGCATCAGTCTGGACCGGCAGATAACGAAGAGTGTGCTTGTGTGCTCACGTCACTTTCGACGCCTCGATTTCAATACCATTCGCAATGGCAAGTACCTGCTGAAACCGCGCGTTTTTCCCACCGTCTTTCCGTGGGGCAAAATGGAGCCCGCTGAGATTGAGGCCGATCATCGTGCGCTCCAACAGGCAACCGTCGATGGCGCGTCGACCAGCGGTGCTGCGAGCAGCGCCACTAGCGAAGATGTCATTAAAGCAACCGTTGATCAAATTGTTGCCCAAATTTTGGCCGAAACGGCTGAGcgaaatgcagcagcagccgcggccGCAGAGGCAGCTGCCAAAGCCGAAGCGGAAGTCAAAGCGGAAGCTAAAGCGGAAGCCGATGCTGAAGGCGTCCAAAAGGAAGCTAAAGCCGCTAAGGAAGCGCCCGTCGAGACGCCAGACGTCGAGGCAACTGTCGAAAGTACAGCTGATGCTGCCGTTCCGGAGGCCGCGGTAGGTTCGTCGGACTCGGCTAATGAAGCGCCAACTGCTGCCAACAGCACCTCGTCACCCCTGTCCAGCATACCGCCCAAATACGGTTCGCCTACAAACACGACGATTGGAGCACGGCTGGAGGCGCTCAGCGTCGACGGCGCCTGGCTGCCGGCACGCATTGTCGAGGTCAACGAGTCGGAGCAAAAGCTCCTCATACGCTTCGAACGCAACAGCAAGCTAAAGGTGTCCCCATCCTCCAGTGGCAGCTACCAGGAATGGATCGACATCAAATCGGAGCGTTTGCGACAGCGCATCAGTTTGCGCGTGCTGCCCCTCTTCGAGCTGGAGGAGAAGTGCATGGCGCGGTGGTCGGGACCACGCAAGTTTCCGGGTACCATCAAGAAGCTGCTGGGCAACGACACCTACGAAGTGCTCTTCGACGATGGGTACACTAAGAACGTACGCGCTGTGCACATGAACAAGCTGCCACGCCAGTTGTCTGCCACAACCGAGGCAGACGTTGAAGCACCCGGCGCCGGttccgcagcagctgcgattGCGGTCAAACGACCAAGTACGGGCGCTCCCAGCACCAACAAGAAGAGCAAGACGACACCTCAACGCAAGGACTGGCCACTGCTGGATATGTCCAATTTGGATTTAGCCGCTCTGGGACTGCCGGACATACCGCACGATGGCGAATGGACCTGCCACTGGGTGAATGATCAGCCCATTGGCTCCGAGGGCTTCCTCATTGTGGGCGAGCATCAGAAGCCAACGGTGATTGTGCACGACTGGCGACTGCCGCCTGGTTGGATCAAGCACATGTACCAGCGCTCCAATGTGCTGGGCAAGTGGGATGTCATACTGGTGTCGCCCAGCGGCAAACGTTTCCGCTCCAAGTCCGATTTAAAGCTGTTCCTGGAGTCGCAGGGACACGTCTACAATCCGGATGTGTACGACTTTAGCATCCATCGCCGGCGCGCCAAGGACATCAATGCGTATGTCTATACGCACGACTACAGTCCGCAGCAGCCGGCAAAGCCGAAGCCGCTGGATGCGTCGCTGGACACCACAGTCACATCGCAGGAACTAAAGAACAGCAAACTATCGACGGATCCGCCCACACCTACGCCCGTGTCAACAATGGGTACACGTTGCGGCCCAGGCGAGGATAGTCAGTATATGGAGACACCGGTCGCCTCATTGATGCCACCCGCAGAGTTGATGTCGCCGTCCCCACATGTCCAAGGCAGTGAGACACAAGCGCCAACAGCTGAAACGGCCGAAGCCAGCTCGGCGCTGGCCGTTGATGAGCAAGGCGCCGTCCTGGTGGAAGACGGATACGCCTTCATTGGCGGATTGAAGGTGCAAATAACGgacaatttgtttgtgtgtccGAGCGAGGGCTGCGGCAAAACCTATCGCAAGGAAGACTTTCTGCAAATACACATACGACATTACCACAAGGAACTGGCACAgCACGTTAGTCACTGTCCCAAAATGCAGGAGCTGGCCGTTAAGCGCACGCATCCCTCGTCGATTGAGCAGGCCGAGCAGACGCCCAAGAACCAAATACCCAATCAACAGTTCTTTGCGAAGCTGCACAACCAAGACCTACAGCGATCACGCTCCTTCCGCCGCCAGCCAGCCGGCACGGATACATCGCCAACGACTCGTGACACATCTCCCAATGTTTCACCCGGCAATCAATTATTGTCGCCAAAAACGGAGACGCCAACGACTCCAAAAAGTGTGGCCCAACCGCCAGCTGTTGGCACACCAGAAGTcatagctgcagcagcatcagcagctgttGTACCATCACCCGCAGTGGAAGTTGCGCCACCAACACCGCAGGAGCCTGCTAAAGTCAGTTCACCAGTCGTTCCCTCGACGACGTCCAATCGCTCCGCCAAACGAGCGCGTCCATCATCTAGCAGGCGCTCGTCCGGGTCGCGTAAGAGCAGCCGGCAACGTACGCAGCGTCGCTACGCTAATGCGTCTCACGGCAAAATCGCTGCAGCCAGCAACTCGCAGAACTCGCCAGCCACTGGAGGGGAATACGACGAAGCGCGAGGCTCATTTGCCACGCTCACGCCGGAAGTTCGCAGCGATGCCAAGAAGCGGCGCATAGCTGTCTCTGGAACGCCGGTCAGTTCGCCGGCCAATATCGATTCTGTGTCAACGCCGACGTCCAACGATCAGGTGGACATAAATGCAGCACTGGCGCCACCGCCGCCTCAACTGGCCAGTCAGACGCCGCAGTACATCAAGGAGAACGGCGAGTTGATACGCATTGTGCGCATGAGGCAGGAGGAAATcatcaattgcatttgcgAGTATGGCGAAGAGGATGGCCTGATGATACAGTGTGAGCTGTGTTTGTGCTGGCAGCACGGCGCCTGCAACGGCATTGTCAAAGAGTCGGACGTGCCCGACAAATACGTCTGTTATATTTGCCGCAATCCACAGCGTGTGCGCGATTCGATGCGCTTCAAGCACGATCAGGATTGGCTCTTCGAAGGCAAACTGCCCGTGGCTGGCTATCACACGCCTAATGCGCAGGCACCCAAAAAGTTCGAGCTGTTAAAGCGGTCACATACGCTGACGGGCAATTTGCTGGATGCTAAGCGTTCCATGCACTCGTTGTTGGTCAAGATCAATATTGCCCGCAATCGCTGCCATCCGAAGCTATATCTGTGGGCCAAGAAATGGGACGAGGATCAGACAGACGCCTCGAACACGCCCGTCAAGCGCATCAAGACCGAACAGGACTGGCCGCACGTGCCGCAACCGGAGGCTGCCATCGATCCTGAGGAGTGCCAACACCGTTTAATAGAGCACGTCAAGGTGCAGCAATCACTGTTGATGAATCGCCTCAACGATATCGAAGCCGAAATGGATGAACTCGAAAAGGAAGATAACCTGCCCGATCTGAAAGATGCAAATATTTCGACCACCAAAGAAGCTATGGCCACGTTTATCAAAGAGCTGGAGACACTAAAACGTCTTGCAAGACTCAACAAAGTGGCCAACATGAAGCAGACTCTGAAGGACCAAGAATCGGCGTCAGATGTTCCCCAAGTGTAA
Protein Sequence: MGRRCCVADCPSTSRLMEHHGVTYHSFPMDAVIRAIWIKNSRISLDRQITKSVLVCSRHFRRLDFNTIRNGKYLLKPRVFPTVFPWGKMEPAEIEADHRALQQATVDGASTSGAASSATSEDVIKATVDQIVAQILAETAERNAAAAAAAEAAAKAEAEVKAEAKAEADAEGVQKEAKAAKEAPVETPDVEATVESTADAAVPEAAVGSSDSANEAPTAANSTSSPLSSIPPKYGSPTNTTIGARLEALSVDGAWLPARIVEVNESEQKLLIRFERNSKLKVSPSSSGSYQEWIDIKSERLRQRISLRVLPLFELEEKCMARWSGPRKFPGTIKKLLGNDTYEVLFDDGYTKNVRAVHMNKLPRQLSATTEADVEAPGAGSAAAAIAVKRPSTGAPSTNKKSKTTPQRKDWPLLDMSNLDLAALGLPDIPHDGEWTCHWVNDQPIGSEGFLIVGEHQKPTVIVHDWRLPPGWIKHMYQRSNVLGKWDVILVSPSGKRFRSKSDLKLFLESQGHVYNPDVYDFSIHRRRAKDINAYVYTHDYSPQQPAKPKPLDASLDTTVTSQELKNSKLSTDPPTPTPVSTMGTRCGPGEDSQYMETPVASLMPPAELMSPSPHVQGSETQAPTAETAEASSALAVDEQGAVLVEDGYAFIGGLKVQITDNLFVCPSEGCGKTYRKEDFLQIHIRHYHKELAQHVSHCPKMQELAVKRTHPSSIEQAEQTPKNQIPNQQFFAKLHNQDLQRSRSFRRQPAGTDTSPTTRDTSPNVSPGNQLLSPKTETPTTPKSVAQPPAVGTPEVIAAAASAAVVPSPAVEVAPPTPQEPAKVSSPVVPSTTSNRSAKRARPSSSRRSSGSRKSSRQRTQRRYANASHGKIAAASNSQNSPATGGEYDEARGSFATLTPEVRSDAKKRRIAVSGTPVSSPANIDSVSTPTSNDQVDINAALAPPPPQLASQTPQYIKENGELIRIVRMRQEEIINCICEYGEEDGLMIQCELCLCWQHGACNGIVKESDVPDKYVCYICRNPQRVRDSMRFKHDQDWLFEGKLPVAGYHTPNAQAPKKFELLKRSHTLTGNLLDAKRSMHSLLVKINIARNRCHPKLYLWAKKWDEDQTDASNTPVKRIKTEQDWPHVPQPEAAIDPEECQHRLIEHVKVQQSLLMNRLNDIEAEMDELEKEDNLPDLKDANISTTKEAMATFIKELETLKRLARLNKVANMKQTLKDQESASDVPQV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00519916;
90% Identity: iTF_00495896;
80% Identity: iTF_00588880;