Dgla000444.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Drosophila glabriapex
Gene Symbol
ham
Assembly
GCA_035042305.1
Location
JAWNLN010000008.1:3925024-3949549[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.57 36 5.0 0.0 2 21 337 356 336 359 0.87
2 9 0.0085 0.53 10.7 0.1 1 23 366 389 366 389 0.92
3 9 1.8e-07 1.1e-05 25.4 1.7 1 23 395 418 395 418 0.96
4 9 3.4e-07 2.1e-05 24.6 1.5 1 23 424 446 424 446 0.97
5 9 8.7e-05 0.0054 17.0 3.8 1 23 452 474 452 474 0.97
6 9 0.0019 0.12 12.8 2.0 2 21 482 501 481 502 0.94
7 9 6.7e-09 4.2e-07 29.9 1.3 1 23 998 1020 998 1020 0.99
8 9 3.6e-07 2.2e-05 24.5 0.9 1 23 1026 1049 1026 1049 0.97
9 9 4.5e-05 0.0028 17.9 6.8 1 23 1055 1077 1055 1077 0.98

Sequence Information

Coding Sequence
ATGTTATTCGATCGTTATGTTATATCAGgCTCTAACGGCGACGATTACGATCCGAGCGTCGTGCgccaccatcaccatcatcatcaccactTGGATCTCAGCAGTGGGGCGCCGGCATTTGCACCATTGCCGCCGGCGCATCTAACCTCCGGTCAGACGAGAGCCGAGGAATCGTTTGGTCGCCACCTGCCGCCAACGATATCCCCGCCACCAGCAacgctccagcagcagcagcagcagcagcagcagcagttgcaacaacagcaacagctgcgacATTCACCGCCCACGCTGCCGCCTGCCTCAGCGTCCGTCTCCAACGGCTCCAGCATGGAGCATCTGTTCAATGACAAGGCGCAGGCGGAACGCTTTCTGCTGGAGATGGCGCGTCTGCGCGAACCCGTCTGTGATCTGGATATACGTGATACTGGCGTCTATGCCAAGACACATCTGCCCCGAGGCACCCGCTACGGACCCTTTCCCATGCGACTCTGCCAGCAGCCCAGCGATCGACACTTGGCCTGGGAGGTGATTGCCGGCCCATTGTTTCACGGTTGGCTGGAACCCTCATCGGATGTGGCCACATGGCTGAAAAAAATACGCGCCGTTCAAAGTGATGAAATCGAAGAGGCTAATTTAAGGAATTTCATCATTGCCGGCTatCTGTGGTACGAGACGAAACGGGACGTAAATGCTGGCGCTGAAATTGTTGTCGATGCCCGTCCGAAAACCCCCTACGATATCAGCGACAGTTTCATGAACGGGGCAGGGGCTGCCGGCGGCGCGGGCAGTGCAACATCGGCGGGGgccagcagcacagcagccgctgcagcggcggcagcagcagcagcagcaactgcaatggcagcggcagcaacatccagcaaaaacaacaacaatggttcGTTGCCAGGCGATGATCGAAGCGATCGTGATAATGGCTTTTATAGCGGAGACGAGAAGAAGGGCGACAACGATTTCACGGACGACGAGAACGGTTTCGATATACGCTGTGAGGTGTGTGATAATGTCTATACGGATTTAGAACGATTGGACGATCATTTAGTGGGCGCACATCATTTCAAGCGCGGAGAATTCCCCTGTGAGCTTTGTGCCCAGCGTTTCAGCCATCGTCCTTTGCTAATCAAGCACGGAGCCATCGCCCATAATAATATACGCAAATATTCCTGCGAGAACTGTTCCAAGGTATTCTGTGACCCATCGAATTTACAGCGTCATATTCGCGCCTATCACGTCGGCGCTCGCAGTCATCCGTGTCCGGAGTGCGGTAAAACGTTTGCCACATCATCGGGCCTcaagcagcatcagcacaTCCACTCATCGGTTAAGCCGTTCGCCTGCGAGGTGTGCTTCaaggcgtatacgcaattctCCAACCTGTGCCGCCACAAGCGGATGCACGCCGACTGTCGCATGCAGATCAAGTGCAAGAAGTGCAACACGAGCTTCAGCACGGTCACCTCGCTGTCCAAGCACAAGAAGTTCTGCGATACCTCGGACAGTTTTCGCAGCCAGCAGCATAGTCGCCTGCAACACGCCCACGATCGCCACCatcaccagcaccagcaccagcatcatcagcagcagcagcagcagcaactctcGCAGCATACGCAGCCGCCGTCACTTCTGTTGCCACCCGGTGCCCATCAGCGACTTGCCGCCGAGACGTCAAATTCGGCCATGGCCACGCCACCAAATCACATTTTTATGATGCGTCCGACGCCGTCGTTCTTTGCTGGCTTTCCCAATTACGGGCTGCATGGCTTATTTCCCGGCTTCCAGCAGGCTGGCAATTTTCCGCTCTCACACATGTTTCCCAATTCGCAGCTGGGCGATATGAGTCGCGGCCTGCCGCCAATTGTCTCCCCAACTGCCGCAttccaacagcagctgcagtcagCGATGAGCATGAAAACAGAATCGCCACGCTTGAAACGCGACTCCAGCACACCGGAGCGTAAGCCCATCAAATCGGAGCTGCATCCCTCCGACGAGGAGTCCAATTCGCTCAGCTACGAAGAGCTCAAGCTGAAGTCGAGCAAGTTGCAGCAGGAGTCCGGCAAGGTGAAGCGGGAACTTAAATCGGAGGCCAGCTGCACCCGGCAAGCCGACGACGACAGCGATCATAACAATAGTGACAATGATAACGATAATGATATTGAAAATGATAGGAAATCGATTGACATTGTTAGCACTCCGCCGCCAGCGGAAACGCAAATGAAGACCGAACCGGAAACGGCGGATGTGGACAAGAGCAGCGCTGAACTGCCGCTGGATCTGTCCATCAGTCGCAAGCGTCGCAGTTCGCTGTGCGCCGCCTCCACGCCCGCCCCGCTCTCCATATCGCTGTCGAGTCGCGATCCATCGCCCGAGCTGGACGCCGAGGACGATgaggacgaggatgaggacgaAGTGGAGCTGCTGGCGCCGCCGGCAAAGCAACCAAAGCACAGTTCCGGCGAATCGAGCACTTCCCGTCAGTCGTACAAGGGCAGCAGTCCGGTGCCAAGTGCAAGTGCCTCTCCCGGACCAACACCCTCACCGTCGCCACCCATCAGCACTGGCGGCGAGCTGAGCAGCATGTCGGAGAGTGCCGCTGCCaatgcaacggcaacggcaacggcaacggcatcggcagctgccgcagccgcagcagcagcggccgccTCAGCGATGGCCTGTCCCCGGCAATTGCatccgcagctgctgctggaggagCTCTACCGTACGCGATTCCCAACGCAGCCGTTTCATTTTTTAGGCCAAATGGGCGGACGGCCAGGTTTTGAGTCACTAAAGTCGCCAGCGATGGGTGCCGCACATGCGCCCATCAGTGGCGGCGGCTCGCGTCATCTGCCGTTTCCGCCCGAGCATAATTTCCACGATGCACTCCGTGCCGCTGGCTTGGCGGCCGCTGCCGCCCGTCCGCCGACAGCGTGCAACGCCAGTGGCAAGCTGAAGGATCGCTATACGTGCAAATTCTGTGGCAAGGTCTTTCCACGCTCCGCGAATCTAACACGGCATCTGCGCACCCACACCGGCGAACAGCCGTACACGTGCAAGTATTGCGATCGTGCCTTCAGCATCTCATCGAATCTGCAGCGTCATGTGCGCAACATCCACAACAAGGAGCGACCATTCCGCTGCCACATGTGCGATCGCTGCTTTGGCCAGCAAACGAATCTCGATCGGCACCTCAAGAAGCACGAGGCAGATGCTGGCGGCTTCGAGTACAACGATTCGCCCAGTTCGAACGAGGCAAATGATCGCGATGAGGCCTGCTTCGATGACATCCGTTCGTTTATGAAACGCGTCTACACGCCCACCAGTTTGGGTGGGGCGGAGGGGGATACGGAGGAGTATGCGGGCAGCGATGATCAGTTGTCCGTTTCCACGCGTCAGTCTGCCAACTTTGACAAGGAGCTGCTCTCGAAtggcaacatcatcaacatcaacaacaacaatagcagcaacaataacaacaacaacaacaatagcaacaacaacaatagcaacaacaacaacaacaatagcaacagcagcagcaacaatcagaCTTTAAATACATCGGAAACAATTGCCGTGAGCACCTAA
Protein Sequence
MLFDRYVISGSNGDDYDPSVVRHHHHHHHHLDLSSGAPAFAPLPPAHLTSGQTRAEESFGRHLPPTISPPPATLQQQQQQQQQQLQQQQQLRHSPPTLPPASASVSNGSSMEHLFNDKAQAERFLLEMARLREPVCDLDIRDTGVYAKTHLPRGTRYGPFPMRLCQQPSDRHLAWEVIAGPLFHGWLEPSSDVATWLKKIRAVQSDEIEEANLRNFIIAGYLWYETKRDVNAGAEIVVDARPKTPYDISDSFMNGAGAAGGAGSATSAGASSTAAAAAAAAAAAATAMAAAATSSKNNNNGSLPGDDRSDRDNGFYSGDEKKGDNDFTDDENGFDIRCEVCDNVYTDLERLDDHLVGAHHFKRGEFPCELCAQRFSHRPLLIKHGAIAHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARSHPCPECGKTFATSSGLKQHQHIHSSVKPFACEVCFKAYTQFSNLCRHKRMHADCRMQIKCKKCNTSFSTVTSLSKHKKFCDTSDSFRSQQHSRLQHAHDRHHHQHQHQHHQQQQQQQLSQHTQPPSLLLPPGAHQRLAAETSNSAMATPPNHIFMMRPTPSFFAGFPNYGLHGLFPGFQQAGNFPLSHMFPNSQLGDMSRGLPPIVSPTAAFQQQLQSAMSMKTESPRLKRDSSTPERKPIKSELHPSDEESNSLSYEELKLKSSKLQQESGKVKRELKSEASCTRQADDDSDHNNSDNDNDNDIENDRKSIDIVSTPPPAETQMKTEPETADVDKSSAELPLDLSISRKRRSSLCAASTPAPLSISLSSRDPSPELDAEDDEDEDEDEVELLAPPAKQPKHSSGESSTSRQSYKGSSPVPSASASPGPTPSPSPPISTGGELSSMSESAAANATATATATASAAAAAAAAAAASAMACPRQLHPQLLLEELYRTRFPTQPFHFLGQMGGRPGFESLKSPAMGAAHAPISGGGSRHLPFPPEHNFHDALRAAGLAAAAARPPTACNASGKLKDRYTCKFCGKVFPRSANLTRHLRTHTGEQPYTCKYCDRAFSISSNLQRHVRNIHNKERPFRCHMCDRCFGQQTNLDRHLKKHEADAGGFEYNDSPSSNEANDRDEACFDDIRSFMKRVYTPTSLGGAEGDTEEYAGSDDQLSVSTRQSANFDKELLSNGNIININNNNSSNNNNNNNNSNNNNSNNNNNNSNSSSNNQTLNTSETIAVST