Basic Information

Insect: Drosophila emarginata
Gene Symbol: zfh1
Assembly: GCA_037075365.1
Location: JBAMCD010000221.1:25731450-25735697[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 3.8e-05 0.0033 18.2 1.4 1 23 147 169 147 169 0.97

2 15 0.00088 0.077 13.9 1.2 3 23 177 197 175 197 0.94

3 15 9.7e-05 0.0085 16.9 0.1 1 23 351 373 351 373 0.98

4 15 0.0012 0.1 13.5 0.7 1 23 379 401 379 401 0.98

5 15 9.3e-05 0.0082 16.9 2.1 1 23 433 456 433 456 0.94

6 15 0.00065 0.057 14.3 1.9 1 23 485 507 485 507 0.95

7 15 0.012 1.1 10.3 1.6 1 23 513 536 513 536 0.97

8 15 0.028 2.5 9.1 0.4 3 19 545 561 544 562 0.95

9 15 0.00017 0.015 16.1 5.6 1 23 571 593 571 593 0.97

10 15 0.05 4.4 8.3 0.4 2 23 599 620 598 620 0.96

11 15 9.9e-06 0.00087 20.0 1.0 1 23 629 651 629 651 0.98

12 15 0.0011 0.098 13.5 0.1 3 23 659 679 657 679 0.97

13 15 6e-05 0.0053 17.5 0.5 1 23 685 707 685 708 0.95

14 15 0.16 14 6.7 0.2 1 23 718 740 718 740 0.97

15 15 0.0074 0.65 11.0 0.6 1 23 1296 1318 1296 1318 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	3.8e-05	0.0033	18.2	1.4	1	23	147	169	147	169	0.97
2	15	0.00088	0.077	13.9	1.2	3	23	177	197	175	197	0.94
3	15	9.7e-05	0.0085	16.9	0.1	1	23	351	373	351	373	0.98
4	15	0.0012	0.1	13.5	0.7	1	23	379	401	379	401	0.98
5	15	9.3e-05	0.0082	16.9	2.1	1	23	433	456	433	456	0.94
6	15	0.00065	0.057	14.3	1.9	1	23	485	507	485	507	0.95
7	15	0.012	1.1	10.3	1.6	1	23	513	536	513	536	0.97
8	15	0.028	2.5	9.1	0.4	3	19	545	561	544	562	0.95
9	15	0.00017	0.015	16.1	5.6	1	23	571	593	571	593	0.97
10	15	0.05	4.4	8.3	0.4	2	23	599	620	598	620	0.96
11	15	9.9e-06	0.00087	20.0	1.0	1	23	629	651	629	651	0.98
12	15	0.0011	0.098	13.5	0.1	3	23	659	679	657	679	0.97
13	15	6e-05	0.0053	17.5	0.5	1	23	685	707	685	708	0.95
14	15	0.16	14	6.7	0.2	1	23	718	740	718	740	0.97
15	15	0.0074	0.65	11.0	0.6	1	23	1296	1318	1296	1318	0.97

Sequence Information

Coding Sequence: ATGAACAATTCGAGTTATGGTAGCATCCAATGGATACAACACCACGCCTCCGCTGACGATACGGAGACGGATGCAATAGACGATGGCGGCGATGCTTATCTGGTTAATGGCACTGCGACGGATGAGGATCTCGATCATATGGCGGCAGAGAATCTAATTTTTATGGCGCGTGATGGTCAGCTGGATGGGATTATTGCTGGAAGTGATCCAGAGTCGGGTGGTGCGGTGCTAGTCACGGCCGATGGCACTACTTTAGCCTATGCCGGCAAATCCTTTGATGATGAAGCCGAGGTGGTCACCGAAGAGGTCATTACCGATGATTGGGTGCAGCATCAAGGAGCTGAGCGggtGGAAATTGCTGCAGAGCAAATAGCTGGTACTACAAGTTCCCAGGAGCTGCTGGATATGGAGCAGGATGAGTATACGGTTCTTCGACCATATCCCTGTGATTTCTGCAGTCGTCGATTCCGCAAGAAGGTCAGTCTCAACAATCACATGCAGGCACATCAAAACGATCGTCCACATCTCTGCAAGCTGTGCGGTGCCCGATTCTCGCGTCGTGGGGAACTGATAAGTCATTTTAAGGCCCACGCCGAGGCTCAGGATGCAGCTGATGCTgaagcagcagcggcagctgcGGCGACTTCAACTGTTAAATatgaacagcaacaacaacgtcaACTAGATGATCATTACTACGAGCAGGATTGGCCTTTGTATCAGCAAGATCATAATCAAGATCAAACCCAGGAGCAGCAATGCTTGATTGTATCCAGCAGTGAGGTGCCGCCACTGATGCAACAAACGAACTATTTAACCGAAAGCAATGTGGTAAGTGCAACACCGATGGCATCTCGTGGCAGGATTAGTCGACTAAAGCCCAAAGAGGAAACAACTCAGTATATTGTGATAACCGAGAATGTGCAGAGTGAACCAACTCAAACGGTGATGACCACATCCAATTTAGTTGATCCTCCACCAGCCGTTGTAACTGCCAGTGATCCTCCACAACAGCTTCTCAACTTCCCAGTGCTGGATGAAGGCAAGCCATTTGTGTGCCAACAATGCGGTTTGGCATTTGCCCGTGAAAAGGCTCTGGTGTCTCATATAAAGAATCATCGCGTGGACTCACCCTTTGAGTGCAATCAGTGTCAAGAGATGTTCTGGGACAACATGAGCCTCCAGGAGCACCAGAAAACGCATCAGTTTGAGGAGAGTAATTCGGAATACGATCCCGCTTCAGCCTCAGATAGTGGGAGCGAGACCGAACCAGAGGAGCAACAAATTTATGGTGAATTTTATTGCAGCGAATGCGGCATTTCCTTTCACAGGCAGAACCTATTGCGTCGTCATGCCAAGGAGCAACACTTCAAATCGACCAATGGCACTTTTCAGCCAACGAGCAGTCAGGAAGAAGCTGCCGGCAATCAGGAAAATGGCACAGAAGCCCCGCACTGTTGTCATACGTGTGGTAAATCCTTTCCCAGCGCCCTCGAGTTGCTTGCCCATGCTGAGATTCATGCCCGTTTCCCGCCCTTCAAGTGTGTGCTATGTGGGATGAGCTTCTATGAGGAGCAAGCCATTAAGCGACATTTGCATACCCGCCATCCACACGAATTGAAGCCCAACTCTTGTGTGTTATGCGGAAAGGAGTGCCGGGATAGGAAGGCACTCATCAAACATGCCTGGGACCATTCACGTGAGAAGTGTCACTCTTGCTCCAAATGCGGTAAAAACTTTCACAATAAGGCACGACTGAAGCGTCACATGGCATCGCACAGGGATAAATCGGTGGTCTGTGAGGTATGCCAAGAAGAGTTTCCCGATGGACGTACTTTATCGAATCATCGGCACTCACACAGCACTACATCGCCAGGGAAACTCTTTCCCTGTCATGAGTGCGGCAAAACCTTTGGCTCACGCAGTTCTCAGCAGATTCATGTACGCATCCATACCGGAGAACGACCGTACGGATGTCGTTATTGCTGGAAGGCTTTCGCCGATGGCGGAACACTGCGTAAACATGAACGCATTCACACAGGGGAGAAGCCCTATGCCTGCTCGGTCTGTCCACGTGCCTTTAATCAGCGCGTAGTTCTCCGTGAACATATACGCTCCCATCACTCTGGTTTGGATGTGTCAAAAGGAACCTACCATTGCACTGTCTGTACGGCAGACTTACCCTCTTCTAACGAGCTTATTCAGCATCTTATCCAGCATAGTGACTCAAACACGGCCAAGCAGAGGCAACCAATTACTGGACCGCGAAAGTACAAGCGACGCCGTAAGCTTCAGCCCCACGAAATAGCACAGTTGCGTGACGATCATCAGGATGTTGAAACTGCCGGCGACGATGGTTTGGGTGAAGATGAGGCTGACGGTAATGCCAGCGACGTTGACATCTGCGATTTTGATATGGAAAATGTGGATGATATCTTTGAAATGACATCCTCTACGCATAACAGCAAAAAGGAAAGGCGCAAAAAGGCGTCGGCAAAGGAAACCAAGCCACAACGGAATGGAACAGGGTCCAAGTCAGGAGCTGGATTGACTCAGCACAAATCTAAACAGCGATATGATTCCAATAGTAGTCAATCAGAACGTATGTGGGGTGATAAACAGGATAATCAAGTGGCCTTCTTTCAAATCGATTCTCTGGTAGTGGTTAATGACACTACACTGGAGCCGGCAAGTTCAATGAGTTGTCCCAATGGTAACACCACCACAAGGACACGAGGACGGTCTGCTAAACAATCGGCACAAATGGAGTCGAAAGTGCCATCTCCAATTGATAGTAAAAACGATGTTATTGCCACATCATATGCTTCCTCCGTCGGCTCCAGTAGTCGTGGTAAAAAGAAGACTGCTACCAAACCAAGTGCAGCCAACGCGTCTCGTCCACGTATGATACACACTGAAAAGGCCAAGATTCCTCGAGCGGCTACAGAGAGTACTACTGCAGGAGGATTGGGCAAGCGGACTCGTGCCAAAACCTACATAGCCCGCACTGAGACCAGCAATTTGGATTTACTTGCAGGCGGTAACGGTAAGACGAATGCCGCAGCAACGGCTGCATCCAATATGGTGGACGATTATGAGATCATTTCCCCTGCCACGCATCCGCCGAATCAGATAAGTTCCAGTCCGTTGCACATAAAACaagagcaggagcagcagcgtGTCCAGTTAATGTACGACGATACTCTCCTTATCGATGCGGCACTTCTTCGGGAGAAGACCTACGAGAAGTTTAATCCGAGCATTGTCAATGATTTGGAGGAGATTCTTCGATCACCGCTTAAAAGTGATCGGAATTCAAGTCGCCTGCGTTTTACCAGTGAATCTTCAACAACGCCACAGTTCCTGCCCGGTGAAGAGCAAAACCTGATTAAAATTGAGCCCACTTCGCCGGATCTACGGGAAATGGTAGAAGGGCAACAGCGGATTACGAATTGTATTGCCACGCCATCCTCCATAGCATCTTCCTCGTCACCGTCAACAGCATGTAATTCGCGTCATTTGCGTCAACTTAGTGCCAATAGTAAGCGAGCGGGCAGTAAACGATCcggtggcagcagcagcagtacaAGTGCCAATAAATCTGCCTCAACAACATCCACAAGTTCTGCGAAAAAAGCAACTCCATCCACGAACACTTCTCCTACGGTTGGTGTTGGTAAAGTCACTAGGAATACTGTTAGCAGCTCTTACCTTAGCTACGGCGTAGGCGTTGATGCGTATAATGTGAATGTACCTGCCAATGGCAGCAATTCCGACGTGAGTTCCGGTTACTTCTCCATCTCCGAGGTTGTCTCCGCCGCCGAAACAGCGGATGCGGCAGCCAAAGAGGCGGCGGCCGGCAAATCGGAGCGCAAGACTCGCAGCTTTGAATGTGAAATGTGTTCGGATGTATTCTATGATCGCAGCCAGTTATTGGAACATGTTCATATTCACATTTAG
Protein Sequence: MNNSSYGSIQWIQHHASADDTETDAIDDGGDAYLVNGTATDEDLDHMAAENLIFMARDGQLDGIIAGSDPESGGAVLVTADGTTLAYAGKSFDDEAEVVTEEVITDDWVQHQGAERVEIAAEQIAGTTSSQELLDMEQDEYTVLRPYPCDFCSRRFRKKVSLNNHMQAHQNDRPHLCKLCGARFSRRGELISHFKAHAEAQDAADAEAAAAAAATSTVKYEQQQQRQLDDHYYEQDWPLYQQDHNQDQTQEQQCLIVSSSEVPPLMQQTNYLTESNVVSATPMASRGRISRLKPKEETTQYIVITENVQSEPTQTVMTTSNLVDPPPAVVTASDPPQQLLNFPVLDEGKPFVCQQCGLAFAREKALVSHIKNHRVDSPFECNQCQEMFWDNMSLQEHQKTHQFEESNSEYDPASASDSGSETEPEEQQIYGEFYCSECGISFHRQNLLRRHAKEQHFKSTNGTFQPTSSQEEAAGNQENGTEAPHCCHTCGKSFPSALELLAHAEIHARFPPFKCVLCGMSFYEEQAIKRHLHTRHPHELKPNSCVLCGKECRDRKALIKHAWDHSREKCHSCSKCGKNFHNKARLKRHMASHRDKSVVCEVCQEEFPDGRTLSNHRHSHSTTSPGKLFPCHECGKTFGSRSSQQIHVRIHTGERPYGCRYCWKAFADGGTLRKHERIHTGEKPYACSVCPRAFNQRVVLREHIRSHHSGLDVSKGTYHCTVCTADLPSSNELIQHLIQHSDSNTAKQRQPITGPRKYKRRRKLQPHEIAQLRDDHQDVETAGDDGLGEDEADGNASDVDICDFDMENVDDIFEMTSSTHNSKKERRKKASAKETKPQRNGTGSKSGAGLTQHKSKQRYDSNSSQSERMWGDKQDNQVAFFQIDSLVVVNDTTLEPASSMSCPNGNTTTRTRGRSAKQSAQMESKVPSPIDSKNDVIATSYASSVGSSSRGKKKTATKPSAANASRPRMIHTEKAKIPRAATESTTAGGLGKRTRAKTYIARTETSNLDLLAGGNGKTNAAATAASNMVDDYEIISPATHPPNQISSSPLHIKQEQEQQRVQLMYDDTLLIDAALLREKTYEKFNPSIVNDLEEILRSPLKSDRNSSRLRFTSESSTTPQFLPGEEQNLIKIEPTSPDLREMVEGQQRITNCIATPSSIASSSSPSTACNSRHLRQLSANSKRAGSKRSGGSSSSTSANKSASTTSTSSAKKATPSTNTSPTVGVGKVTRNTVSSSYLSYGVGVDAYNVNVPANGSNSDVSSGYFSISEVVSAAETADAAAKEAAAGKSERKTRSFECEMCSDVFYDRSQLLEHVHIHI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00555992; iTF_00612228; iTF_00571319; iTF_00523850; iTF_00618573; iTF_00555250; iTF_00503414; iTF_00604255; iTF_00591119; iTF_00577936; iTF_00483863; iTF_00600476;
90% Identity: iTF_00591119;
80% Identity: -