Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_949752805.1
Location
OX457097.1:12287928-12299404[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 4.4 1.4e+04 -3.6 0.0 22 41 367 386 362 387 0.81
2 3 1.7 5.4e+03 -2.2 0.0 29 48 405 424 400 427 0.83
3 3 3.4e-17 1.1e-13 51.2 0.0 5 69 751 814 747 816 0.94

Sequence Information

Coding Sequence
ATGGCCGTAAAACAATGTTGCATAGAGAACTGTAAGTCCTGCTCATCAAGAAAGGAAGACAATGGTGTCACATATCACAAATTTCCCAAAGATCCAGCCTTACGTAACATTTGGAAGTCAATAACATGTTGCAATGATTCCGACTTGCCGAAGTTTGTTTGCTCGaggcatttttataaaaacgatTTTCAAATGTACAAGGACTCTAAATACATACTGAAGTCAGATGCAGTACCTTCAATATTTCCATGGACTATGACAAAAATTGTTGACACCACAACAATGGAGACCGTGGGTAGTGTATTGGAAAATGCTACGGCAAGCACATCagatgcaaataaattaaatacatccaacagtagTAAAGATTCAGAAGAGAATGTGGAAGCTATAAAACAATTCATTGAAGACCAAGAGAAAGAATTTCAAGAGAAGAATGATGCAGCTAATATTGTCAAgatggaaaatattaaaaatgaacctGCAAATGAAGatgttaaaattgaaaatgCCAGAGAAACAATGGCGGTTGCATCCAGTGTTATGGATATGATTCTTAGTGAGTCGGAAGCAAAGATAGAGAAAAAACATGAAATTGCTCCTGCGCCTAAGTATAGCATTAGTCCCACTGATAAATTCACAAGTGGTAGCATTTCTCTATCTGTTGGTTCGAGAATTGAAGCCAAGGATTTTAGTGAAGAATGGCACCCAGCAGAAATTGTGGAggtcgattttgatgaaatggAAGTCTTGGTTAGATATGAACCGGCTAACAAAATTGTTTCCAGACATGACGAATGGATCAGCGTAAGTAGTCCACGCCTACGGCCTCTTAGTGGCACCACTCCCAAAACTGAGATTAAAGAAGAAACCAAGATGCCAGAGAAGGAAGCGCCAGTCAAAGAAGAggtgaaagaaataaaacaagaagAGAAGGCGAAAGTAACGTTTGCGGTGGGGGAGAGATGTCTGGCGCGATGGAGGGACAACAGACGGTTCATGGCCACTGTACAGAAAGAGTTGGAGGATGGCAGCTACGAGATAATATTCGATGACAACTTCAAATGGAAATGTAGCGTGTCCAGGCTTTATAAATGGAAACCCACGGGCAAACCTGAGCTTACTGTAGAGACATCGTTAAATTCTCCCACGGGTTCAGCATCGCCTATACAATGGGGTGGTCCCAGTACTATCGACGCAGCGGGCAATAACTCAGCATTCCACACACACCTCTTCGACCCAACTCGAGATTACTTGAGCTCCAAAAGCGAGCGTAGAGAGATGAAGAGGAAATTGAACATAAAGGAGATCTTCAACATTGGGCAAAAGAGACAGAAGACGAAACCAGACAAAGAGGTTACGATGTCTAAACGCCCGAGGATTATAAGGAGGTCTACTAAAGTTAAACCTAAAGCAGTAGTTAAGGTTGAAATAAAAACGGATATACCTGATGCTGTTGCCTCCATCATTGGCACACATCCAAAACAGGAAACCATTGTATCAGAAATAAGGATTGATGTCGAACCAGAAATTAAACTAGAACAAAACATTGAGTTAAATAAGGAAGATATTGTTGAAGATGATAAAAAAACTGACATAGCGGACACACAGGTAGCAGATGCTTTTAAAATGGATGAATATAAAGCTGACTTAGATCCTGTACACGAGGAAGATGTGAAGCTAGAGAAATTTGAGAAACAAGATGATGGTAAACACGAAGAAGTAATTGATAGAATGAAAGAAGTCATCAGCAAACTAGAAGTTggattaaatgaaaatgaaaaagtaaATACCCCTAAAGTAGAACCCAAGGAAGAAACTCCAATCCCTGTCAAAGTTGATACAGAAATTAAAGAGGTAGAAATTCCAAAAACTAAAGAGGCAGATGAAAACGTATTCGTAGACGTAGATGGACTTGATGCTGTTGAACCACCAAAACCAACTAAAAAACTGTCAAAGATAAAGAAAGGCAAAAAGATAAGATTACTGCAGGAGAAAAAGGTGAAGAAACAGGTGGAGATTGTAAAGAAAGAGATGGAAGAGATGCGGAAACAGGTGGAAGAAATGAGAAAGCAGATGTTACGGACGCAAGAGTTATCGAAGGGCCAGGAGATGCCGGAGAGTTTCTTGTTGCCGGGAGAGTGGTGTTGCAAGTGGTTGAATGGGCAGCCGGTCGGGGCGGTTAGCGAGATTGTATGTGAACCGAGAACGGACAGCGAGGGAAAACAGGGTTTACCACGGAGAAGTGTTCAGgtGGAAGATAAACGACTACCTCCAGGCTGGACGAAACACATGGTTCGGAGGAGCTTGGGTCATTCTGCCGGGAAATGGGATGTTGTACTTGTCAGCCCAGAAAACCGCCGCTTCCATACTAAGACAGACATGCGGAATTATCTTGAAAATAATCCTGATGAAGCTCTTAAACCGTATGAATTCGCGCTAATGGATTTCGGAGTGCATTTGAAATTATCTCGGCGTATGGGTTGGATATCGACTACACCGGGGGGCGTTGCTGACGGGCCCTCAGTCTCTCCAAGTATAGTGAGCTGCACCTCGCCTCTGATCAAGAAGAGAAAGAAATCAGAGAAGAaaagagaaaagaaaaaattgTCTTTGAAAATGAAGATTGTTGTGCCTACTGAAAGTGTTGCACACGAGCCGATCAATATAGATGCCACATCGGACACGGTGCCCACGCCTGAACCAACCCTCAACACAGTTGCTTTAGAAGACGGATACGTCTACGTCGGTTCACTCAAAGTTCAAATAATCGAGAATTTGCTTCGATGTCCAGCTGAAGGTTGCTTCAAGAATTTCCGAAACAACACACTATTACAGATGCATATAAAACATTACCATAATGAGCTAAGAGAAATGTTAGGAGATACTCCGAAGGTCTTGGACTTGGCATACGCCAGGACAATGCCAGTAGACCCTGACCCGCCGAAACAAGTCGATTCTAAGGTCATTAAGGTCAAAATACCAAAACCACCGAAACGTGAAGAGCCGAAACGAGTCGAACTAGAACCTTTGGACATCAAACCTGATTTAATACTTGATACCGCTCCCAAAACACCAGTTAGCCTTGAGGGGGATAGTATTCCGAAACTGCAAGATTCTCCTAAGTTACGCGATGCGTTGATCAACAAGCCAGTGAAGAGACCAAAGGTCTTACTGCCAGTAAGAAGACCAGAGTTTGACCCAGAACCCACTAACATCGAAGATTTTGATGCGGTGTTACCAGAGATTCCACCAGAGAGCAGTATGATAGATGTGTTAGATTTCGAAACGGCGATATCGACGCACACAGTGACTAAGCCGTTTTCGGAGAAGCGGAAGAAAGGGGACAAGAAACGGAAGTCGTTGACGCTGATGCCTCAGAAGATGAGCGAAGATGAGGAGTGGTTCGCGGCGACTTCTGATGTGGAGACAAGGTCTAGTTTCCCTCGGTCTGGTACGCCTGACTCTAAGATGGCGGAGGTGCCACCGATGCAGGAGGTCGGAGCTTTGTCCGCGGAGTCTAATGAAGAACAAAAGGATTCTCATAAGTACATGTATAATGAGAACGGCGAGCGCGTGAAGATCGTTCACATGAAGCGCGAGGAGATCATCAACTGTCACTGCGGCTATCGCGAGGAGGACGGGCTCATGGTGCAGTGCGAGTTGTGTCTGTGCTGGCAGCACGCGCTCTGCCACAACATACACAGCGAGGcccagGTCCCAGAGAAGTACACATGCAGTATTTGCTTAAATCCCCGTCGCGGTCGTCGCTCGCAGCGGTTCCTTCACGACCAGGACCGTCTGTACGAGGGGCTGCTGCCGGGGGCGAAGCCCTGCGACATGCTCCGGCGCTCGCACGAGCTGTCCGGCAACCTGCTGCGCATACAGGACGCCCTGCACGCGCTCAGGGTCAAGTGCTATGTTGCTAGCAAAAAAGACCACCCGAAGCTATACCTGTGGGCCAAAGACTGGGAGCATGCAGAGTTGTCGTACACGCAGGAGAAACTCAATTCTGACTACACGGATCTCAACATAATGATCAATAGCGTCGGCAAGGAGAACATGCCCGTCCAACCCGAGGACATCAAGGATATGCAGCTCGACGTCAGGGGCACGCTGTGTGATGACCAGGACTCTGACAGGTTCTCGCAGCGGACGGATAGTCAACTGAGTAATGTGTTGTTGAACAACTTGCTGTCGAGTCCAGGCGGCGCGTCACTAGATTTGCCCATAAGCACCTCAGAGTTGGAGACACTTGCCAAATCTGTTCAAGAGCAAGTGTGCCTGGGCGGGGCGGGGTGCGCGCCGCAGCCCGAGGCGGCCATCGAGAACGGCGCGTGCCGCGTGCGCCTGCTGCGCCACCTGCAGCGCTGCCACGCGCTCGTCGACGCGCGGCTCGACTCCATCGAGGCGCAGGTCGCAGAATTGGAATCTCAAGATCCGTCGTTCGAGGACGACGAGACGCCGGACTTTTTCCCGCGAACCAAACACACTGTGCAGATGCTACTACGAGATCTGGACACCATGGAAGAACTTGGAGTCATCACTTAA
Protein Sequence
MAVKQCCIENCKSCSSRKEDNGVTYHKFPKDPALRNIWKSITCCNDSDLPKFVCSRHFYKNDFQMYKDSKYILKSDAVPSIFPWTMTKIVDTTTMETVGSVLENATASTSDANKLNTSNSSKDSEENVEAIKQFIEDQEKEFQEKNDAANIVKMENIKNEPANEDVKIENARETMAVASSVMDMILSESEAKIEKKHEIAPAPKYSISPTDKFTSGSISLSVGSRIEAKDFSEEWHPAEIVEVDFDEMEVLVRYEPANKIVSRHDEWISVSSPRLRPLSGTTPKTEIKEETKMPEKEAPVKEEVKEIKQEEKAKVTFAVGERCLARWRDNRRFMATVQKELEDGSYEIIFDDNFKWKCSVSRLYKWKPTGKPELTVETSLNSPTGSASPIQWGGPSTIDAAGNNSAFHTHLFDPTRDYLSSKSERREMKRKLNIKEIFNIGQKRQKTKPDKEVTMSKRPRIIRRSTKVKPKAVVKVEIKTDIPDAVASIIGTHPKQETIVSEIRIDVEPEIKLEQNIELNKEDIVEDDKKTDIADTQVADAFKMDEYKADLDPVHEEDVKLEKFEKQDDGKHEEVIDRMKEVISKLEVGLNENEKVNTPKVEPKEETPIPVKVDTEIKEVEIPKTKEADENVFVDVDGLDAVEPPKPTKKLSKIKKGKKIRLLQEKKVKKQVEIVKKEMEEMRKQVEEMRKQMLRTQELSKGQEMPESFLLPGEWCCKWLNGQPVGAVSEIVCEPRTDSEGKQGLPRRSVQVEDKRLPPGWTKHMVRRSLGHSAGKWDVVLVSPENRRFHTKTDMRNYLENNPDEALKPYEFALMDFGVHLKLSRRMGWISTTPGGVADGPSVSPSIVSCTSPLIKKRKKSEKKREKKKLSLKMKIVVPTESVAHEPINIDATSDTVPTPEPTLNTVALEDGYVYVGSLKVQIIENLLRCPAEGCFKNFRNNTLLQMHIKHYHNELREMLGDTPKVLDLAYARTMPVDPDPPKQVDSKVIKVKIPKPPKREEPKRVELEPLDIKPDLILDTAPKTPVSLEGDSIPKLQDSPKLRDALINKPVKRPKVLLPVRRPEFDPEPTNIEDFDAVLPEIPPESSMIDVLDFETAISTHTVTKPFSEKRKKGDKKRKSLTLMPQKMSEDEEWFAATSDVETRSSFPRSGTPDSKMAEVPPMQEVGALSAESNEEQKDSHKYMYNENGERVKIVHMKREEIINCHCGYREEDGLMVQCELCLCWQHALCHNIHSEAQVPEKYTCSICLNPRRGRRSQRFLHDQDRLYEGLLPGAKPCDMLRRSHELSGNLLRIQDALHALRVKCYVASKKDHPKLYLWAKDWEHAELSYTQEKLNSDYTDLNIMINSVGKENMPVQPEDIKDMQLDVRGTLCDDQDSDRFSQRTDSQLSNVLLNNLLSSPGGASLDLPISTSELETLAKSVQEQVCLGGAGCAPQPEAAIENGACRVRLLRHLQRCHALVDARLDSIEAQVAELESQDPSFEDDETPDFFPRTKHTVQMLLRDLDTMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2