Hlin014645.2
Basic Information
- Insect
- Hyles lineata
- Gene Symbol
- MBD-R2
- Assembly
- GCA_030180105.1
- Location
- JARJEE010000017.1:4614066-4627037[-]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 0.83 2.3e+03 -1.1 0.0 24 48 403 426 398 429 0.84 2 2 3.2e-16 8.7e-13 48.3 0.0 5 67 761 822 757 831 0.91
Sequence Information
- Coding Sequence
- ATGGCCGTAAAACAATGTTGCATAGAGAACTGTAAGTCCTGCTCATCAAGGAAGGAAGATGATGGTGTCACATATCACAAATTTCCCAAAGATCAAGCCTTATGTAATATTTGGAAGTCAATAACATGTTGCAATGACTCCGACTTGCCGAAGTATGTGTGCTCAaggcatttttataaaaacgatTTTCAAATGTACAAGGACTCTAAATACATATTGAAGTCAGATGCAGTGCCTTCAATATTTCCATGGACTATGACAAAAATTTTTGACACTACAGCAATGGAGACTGTGGATAGCGTATTGGAAAAGCAGGAAGCTGCAGCAAGCACATCCGATGcgccaaataaattaaatacatccaacagcaGCAAAGAATCAGAAGAGAATTtggaagcaataaaaaaattcattgAAGACCAAGAGAAAGAATTTCAAGAGAAGAATGATGCAGCTAACATTGTTAAGacggaaaatattaaaaatgaacctgctaataaagatgttaaaattcataattctGAAGAAACAATGGCAGTTGCATCCAGTGTTATGGATATGATTCTTAGTGAGTCGGAAGCAAAGATAGAGAAAAAACATGAAGTTGCTCCTGTGCCTAAGTATAGCATTAGTCCCGCTGATAaattcACAAGTGGTAGCATTTCTCTATCTGTTGGTTCAAGAATTGAAGCCAAGGATTTTAGTGAAGAATGGCATCCAGCAGAAATTGTGGAGgttgattttgatgaaatgGAAGTCTTGGTCCGATATGAACCGGTTAACAAAATTGTTTCTAGACACGACGAATGGATAAGCGTCAGTAGTCCACGCCTACGGCCTCTTAGCGGCAACACTCCCAAAACGGAGGTTAAAGAAGAAACAAAGATGCCAGAGAAGGAAGCGCCTGTCAAAGAAGAAGTTAAAGAAGTAAAACAAGAAGAGAAGGCGAAGGTAACGTTTGCGGTTGGAGAGAGATGTCTGGCGCGATGGAGGGACAACAGACGGTTCATGGCTACTGTACAGAAGGAATTGGAGAATGGCAGCTACGAGATAATATTCGATGACAACTTCAAATGGAAATGTAGCGTGTCCAGACTTTATAAATGGAAACCTACTGGCAAACATGAACATGTAGAGACATCGTTAAATTCTCCCACGGGTTCCGCATCGCCTGTACAATGGGGGGGACCTAGTACCATCGACTCAGCGGGCAATAAGTCAGCATTCCATACACACCTCTTCGATCCAACGCGAGATTACTTGAGCTCCAAAAGCGAGCGTCGAGAAATGAAGAGGAAATTGAACATTAAGGAGATATTCAACATCGGGCAAAAGAGACAGAAGACGAAACCAGATAAGGAAGTTACAATGTCTAAACGCCCCAGGATTATAAGGAGGTCTACTAAAGTTAAAAAACAACCAATAGTTAAGGTTGAAGAGaaagttgaaattaaaaaagaggGATCCGATGCCGTTGCCTCCGTCAATGCAACACATACGAAACCAGAAACCATTGTATCAGAAATAAGGATTGATGTTGAATTTGAACAAGACATTGAGTTAAAAAAGGAAGATATCGTTGAAGATGTTAAAACTTCCGAGATAGCGGACTCACAGGTAGCAGATGCTTTTAAAATGGACGAATATAAAGCTGATTTAGACCCTGTGCACGAGGAAGATGTGAAACTTGAGAAGTTTGAAAAGCAAGATGACTGTAAACATGAACAAGTCATTGACAGGATGAAAGAAGTAATCAGCAAGCTAGAAGTTggattaaatgaaaatgaaaaagtttATTCCCCGAAAGTAGAACATAAAGAAGAAGTTTCAATCCCTGTCAAAGTTGATACCGAAATTAAAGAGGCAGAAATTCCAAAAACCAAAGAAGAAGAAATTCCAAAAACAAAAGAGTCCGATGAAAACGTATTCGTAGACGTAGATGGACTTGATACTGTGGAACCACCAAAACAGTCTAAAAAACTGTCAAAGATAAAGAAAGGTAAGAAGATACGATTGCTGCACGAGAAAAAAGTGAAGAAACAGGTGGAAATAGTGAAGAAAGAGATGGAAGAGATGCGGAAACAGGTGGAGGAAATGAGAAAGCAGATGTTGCGGACGCAGGAGTTGTCGAAGGGCCAGGAGATGCCGGAGAGCTTCTTGTTGCCGGGAGAGTGGTGCTGCAAGTGGTTAAACGGCCAGCCAGTGGGAACAGTTAGCGAGATTGTATGCGAGCCGAAAACGGACAGCGAGGGAAAACCGGGTTTGCCGCGGAGGAGTGTTCAGgtgGAAGACAAGCGATTACCTCCAGGCTGGACTAAACACATGGTTCGAAGGAGTTTGGGACATTCTGCCGGAAAGTGGGATGTCGTACTTGTTAGCCCAGAAAACCGCCGCTTCCACACCAAAACAGACATGAGGAATTACCTTGAAAACAACCCTGATGAAGCTCTAAAACCGTACGAATACGCGCTAATGGATTTCGGAGTACATTTGAAATTATCTCGGCGCATGGGTTGGATATCGACTACACCAGGTGGCGTTGCTGACGGGCCCTCAGTGTCTTCAAGTATATTGAGCTGCACCTCGCCTCTGATCAAGAAGAGAAAGAAATCGGAGAAGAAAAGAGAGAATAAGAAGATGCCTTTGAAAATGAAGATAGTTGTGCCTCCTGAAAGTGTTGCACACGAGCCGATCAATATAGACACCACATCAGACACAGTACACACGCCTGAACCACCCCTCAACACAGTGGCTTTAGAAGACGGATACGtgTACGTCGGCTCGCTCAAAGTTCAAATAATCGAGAATCTTCTCCGATGTCCAGCCGAAGGTTGCTTCAAGAATTTCCGAAACAACACGCTATTACAGATGCATATAAAACATTACCATAGAGAGCTAAGAGAAATGTTAGGAGATACTCCGAAGGTCTTGGATTTGGCGTATGCCAGGACAATGCCAGTGGACCCTGATCCGCCGAAACAAGTTGATTCTAAGATCATTAAGGTCAAAATACCCAAGCCACCTAAACGTGAAGAGCCGAAACGAGTGGAACTAGAGTCTTTGGACATCAAGCCTGATTTAATACTTGATACAGCACCTAAAACACCAGCAAGCCAAGAAGGAGATAGTATTCCTAAAGTGCAGGACTCTCCTAAGTTACGCGATGCGTTGATCAACAAGCCGGTGAAGAGACCAAGGGTATTACTTCCAGTTAGAAGACCAGAGTTTGACCCAGAACCAACTAATATCGAAGATTTTGATGCCGAGTTACCAGAGATTCCACCAGAGAGCAACTTGATAGATGTGTTGGATTTCGAAAAGGCGATATCTACTCACACGGTGACTAAACCGGAGAAGCGGAAGAAGGGAGACAAGAAACGGAAGTCATTGACTCTGATGCCGCAGAAGCACAGCGAAGATGATGAGTGGTTAACGGCGACTTCTGATGTGGAGACGAGGTCTAGTTTCCCGCGTTCTGGTACGCCTGACTCGAAAATGGCCGAAGCAACGCCGATGCAGGAAGTAAGCGCTATGTCCGCGGATTCTAATGAGGAACAGAAGGATTCCCACAAATACATGTATAATGAGAACGGTGAGCGCGTGAAGATCGTGCACATGAAGCGCGAGGAGATCATCAACTGCCACTGCGGCTACCGCGAGGAGGACGGGCTCATGGTGCAGTGCGAGCTGTGTCTGTGCTGGCAGCACGCGCTCTGCCACAACATACACAGCGAGGCGCagGTGCCAGAGAAATACACGTGCAGCATATGCCTGAACCCGCGGCGCGGTCGGCGCTCGCAGCGGTTCCTGCACGACCAGGACCGGCTGTACGAGGGCCTGCTGCCGGGGGCCAAGCCCTGCGACATGCTGCGGCGCTCGCACGAGCTGTCCGGCAACCTGCTGCGCATACAGGACGCCCTGCACGCGCTCAGGGTCAAGTGCTATGTTGCTAGCAAAAAAGACCATCCCAAACTGTACCTGTGGGCCAAAGACTGGGAGCACGCGGAGTTGTCGTACACGCAAGAGAAGCTCAACTCGGACTACACGGACCTGAACATCATGATCAACAGCGTTGGCAAGGAGAACATGCCCATCAAGCCAGAGGACATCAAGGATATGCAGCTGGACATCAGGGGCACGCTGTGTGATGATCAGGACTCTGACAGGTTCTCGCAGCGGACAGACAGTCAACTGAGTAACGTGCTGTTGAATAACTTGCTGTCGAGTCCTGGCGGTGCATCACTAGATCTGCCCATAAGCACATCCGAGCTGGAGACTCTTGCCAAATCTGTTCAAGAGCAAGTGTGCGCGGGCGTGGTGTCGAGCGCGCCGCAGCCCGAGGCGGCGATCGAGAGCGGCGCGTGCCGCGTGCGCCTGCTGCGCCACCTGCAGCGCTGCCACGCGCTCGTCGACGCGCGGCTCGACTCCATCGAGGCGCAGGTGGCCGAACTGGAATCTCAAGATCCTTCGTTCGAGGACGACGAGACGCCGGACTTCTTCCCGCGCACCAAACACACTGTTCAAATGTTACTACGAGACCTGGAAACGATGGAAGAACTAGGAGTCATCACTTAA
- Protein Sequence
- MAVKQCCIENCKSCSSRKEDDGVTYHKFPKDQALCNIWKSITCCNDSDLPKYVCSRHFYKNDFQMYKDSKYILKSDAVPSIFPWTMTKIFDTTAMETVDSVLEKQEAAASTSDAPNKLNTSNSSKESEENLEAIKKFIEDQEKEFQEKNDAANIVKTENIKNEPANKDVKIHNSEETMAVASSVMDMILSESEAKIEKKHEVAPVPKYSISPADKFTSGSISLSVGSRIEAKDFSEEWHPAEIVEVDFDEMEVLVRYEPVNKIVSRHDEWISVSSPRLRPLSGNTPKTEVKEETKMPEKEAPVKEEVKEVKQEEKAKVTFAVGERCLARWRDNRRFMATVQKELENGSYEIIFDDNFKWKCSVSRLYKWKPTGKHEHVETSLNSPTGSASPVQWGGPSTIDSAGNKSAFHTHLFDPTRDYLSSKSERREMKRKLNIKEIFNIGQKRQKTKPDKEVTMSKRPRIIRRSTKVKKQPIVKVEEKVEIKKEGSDAVASVNATHTKPETIVSEIRIDVEFEQDIELKKEDIVEDVKTSEIADSQVADAFKMDEYKADLDPVHEEDVKLEKFEKQDDCKHEQVIDRMKEVISKLEVGLNENEKVYSPKVEHKEEVSIPVKVDTEIKEAEIPKTKEEEIPKTKESDENVFVDVDGLDTVEPPKQSKKLSKIKKGKKIRLLHEKKVKKQVEIVKKEMEEMRKQVEEMRKQMLRTQELSKGQEMPESFLLPGEWCCKWLNGQPVGTVSEIVCEPKTDSEGKPGLPRRSVQVEDKRLPPGWTKHMVRRSLGHSAGKWDVVLVSPENRRFHTKTDMRNYLENNPDEALKPYEYALMDFGVHLKLSRRMGWISTTPGGVADGPSVSSSILSCTSPLIKKRKKSEKKRENKKMPLKMKIVVPPESVAHEPINIDTTSDTVHTPEPPLNTVALEDGYVYVGSLKVQIIENLLRCPAEGCFKNFRNNTLLQMHIKHYHRELREMLGDTPKVLDLAYARTMPVDPDPPKQVDSKIIKVKIPKPPKREEPKRVELESLDIKPDLILDTAPKTPASQEGDSIPKVQDSPKLRDALINKPVKRPRVLLPVRRPEFDPEPTNIEDFDAELPEIPPESNLIDVLDFEKAISTHTVTKPEKRKKGDKKRKSLTLMPQKHSEDDEWLTATSDVETRSSFPRSGTPDSKMAEATPMQEVSAMSADSNEEQKDSHKYMYNENGERVKIVHMKREEIINCHCGYREEDGLMVQCELCLCWQHALCHNIHSEAQVPEKYTCSICLNPRRGRRSQRFLHDQDRLYEGLLPGAKPCDMLRRSHELSGNLLRIQDALHALRVKCYVASKKDHPKLYLWAKDWEHAELSYTQEKLNSDYTDLNIMINSVGKENMPIKPEDIKDMQLDIRGTLCDDQDSDRFSQRTDSQLSNVLLNNLLSSPGGASLDLPISTSELETLAKSVQEQVCAGVVSSAPQPEAAIESGACRVRLLRHLQRCHALVDARLDSIEAQVAELESQDPSFEDDETPDFFPRTKHTVQMLLRDLETMEELGVIT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00428145;
- 90% Identity
- iTF_00428145;
- 80% Identity
- iTF_00819243;