Basic Information

Insect: Deilephila porcellus
Gene Symbol: MBD-R2
Assembly: GCA_905220455.1
Location: LR999973.1:12611508-12623096[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.4 1.2e+04 -3.6 0.0 22 41 367 386 362 387 0.81

2 3 1.2 5.5e+03 -2.6 0.0 31 48 407 424 401 427 0.84

3 3 1.9e-17 9e-14 51.2 0.0 5 69 755 818 751 820 0.94

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.4	1.2e+04	-3.6	22	41	367	386	362	387	0.81
2	3	1.2	5.5e+03	-2.6	31	48	407	424	401	427	0.84
3	3	1.9e-17	9e-14	51.2	5	69	755	818	751	820	0.94

Sequence Information

Coding Sequence: ATGGCCGTAAAACAATGTTGCATAGAGAACTGTAAGTCCTGCTCATCAAGGAAGGAAGACAATGGTGTCACATATCACAAATTTCCCAAAGATCCAGCCTTACGTAACATTTGGAAGTCAATAACATGTTGCAATGATTCTGACTTGCCGAAGTTTGTTTGCTCGAGGCATTTTTATAAAAATGATTTTCAAATGTACAAGGACTCTAAATACATATTGAAGTCAGATGCAGTGCCTTCAATATTTCCATGGACTATGACAAAAATTGTTGACACCACAGCAATGGAGACCGTGGGTAGTGTATTGGAAAATGCTAAGACAAGCACATCAGATGCAAATAAATTAAATACATCCAACAGTAGTAAAGATTCAGAAGAGAATGTGGAAGCAATAAAACAATTCATTGAAGACCAAGAGAAAGAATTTCAAGAGAAGAATGATGCAGCTAACATTGTTAAGATGGAAAATATTAAAAATGAACCTGCAAATAAAGATGTTAAAATTGAAAATGTTAAAGAAACAATAGCGGTTGCATCCAGTGTTATGGATATGATTCTTAGTGAGTCGGAAGCAAAGATAGAGAAAAAACATGAAATTGCTCCTGCGCCTAAGTATAGCATTAGTCCCGCTGATAAATTCACAAGTGGTAGCATTTCTCTATCTGTTGGTTCGAGAATTGAAGCTAAGGATTTTAGTGAAGAATGGCACCCAGCAGAAATTGTTGAGGTTGATTTTGACGAAATGGAAGTCTTGGTTAGATATGAACCGGCTAACAAAATTGTTTCCAGACATGACGAATGGATCAGCGTAAGTAGTCCACGCCTACGGCCTCTTAGTGGCACCACTCCCAAAACTGAGGTTAAAGAAGAAACCAAGATGCCAGAGAAGGAAGCGCCAGTCAAAGAAGAGGTCAAAGAAATAAAACAAGAAGAGAAGGCGAAAGTAATGTTTGCGGTGGGGGAGAGATGTCTGGCGCGATGGAGGGACAACAGACGGTTCATGGCCACTGTACAGAAAGAATTGGAGGATGGAAGCTACGAGATAATATTCGATGACAACTTCAAATGGAAATGTAGCGTGTCCAGGCTTTATAAATGGAAACCCACGGGCAAACCTGAGCTTACTGTAGAGACATCGTTAAATTCTCCCACGGGTTCCGCATCGCCCATACAATGGGGTGGTCCCAGTACTACCGACGCAGCGGTCAATAAGTCAGCATTCCACACACACCTCTTCGACCCGACCCGAGATTACTTGAGCTCCAAAAGCGAGCGTAGAGAGATGAAGAGGAAATTGAACATAAAGGAGATCTTCAACATTGGGCAAAAGAGACAGAAAACGAAACCAGACAAAGAGGTTACAATGTCTAAACGCCCGAGGATTATAAGGAGGTCTACTAAAGTTAAACCTAAAGCAGTAGTTAAGGTTGAAGAGAAAGTTGAAATTAAAACGGATATACCTGATGCTGTTGCCTCCATCATTGGTACACATCCAAAACAGGAAACCATTGTATCAGAAATAAGGATTGATGTCGAACCAGAAATTAAACTAGAACAAAACATTGAGTTAAATAAGGAAGATATTGTTGAAGATGATAAAAAAACCGCCGTAGCGGACACACAGGTAGCAGATGATTTTAAAATGGATGAATATAAAGCTGACTTAGATCCTGTACATGAGGAAGATGTGAAACTAGAGAAATTTGAGAAACAAGATGATGGTAAACACGAAGAAGTAATCGATAGAATGAAAGAAGTCATCAGCAAACTAGAAGTTGGATTAATTGAAAATGAAAAAGTAAATAGCCCCAAGGTAGAACCCAAGGAAGAAACTCCAATCCCTGTCAAAGTTGATACAGAAATTAAAGAGGTAGAAACTCCAAAAACTAAAGAGGCAGATGAAAACGGTTTCGTAGACGTAGATGGACTTGATGCTGTGGAACCACCAAAACCATCTAAAAAACTGTCAAAAATAAAGAAAGGCAAAAAAATAAGATTACTGCAGGAGAAAAAGGTGAAGAAACAGGTGGAGATTGTGAAGAAAGAGATGGAAGAGATGCGGAAACAGGTGGAGGAAATGAGAAAGCAGATGTTACGGACGCAAGAGTTATCGAAGGGCCAGGAGATGCCGGAGAGTTTCTTGTTACCGGGAGAGTGGTGTTGCAAGTGGTTGAATGGGCAGCCGGTCGGGGCGGTTAGCGAGATTGTATGTGAACCGAGAACGGACAGCGAGGGAAAACAGGGTTTACCACGGAGAAGTGTTCAGGTGGAAGATAAACGACTACCTCCAGGCTGGACGAAACACATGGTTCGGAGGAGCTTGGGTCATTCTGCCGGGAAATGGGATGTTGTACTTGTTAGTCCAGAAAATCGCCGCTTCCACACTAAGACAGACATGAGGAATTATCTTGAAAATAACCCTGATGAAGCTCTTAAACCGTACGAATTCGCGCTAATGGATTTCGGAGTGCATTTGAAATTATCTCGGCGCATGGGTTGGATATCGACTACACCGGGGGGCGTTGCTGACGGGCCCTCAGTCTCTCCGAGTATAGTGAGCTGCACCTCGCCTCTGATCAAGAAGAGAAAGAAATCAGAGAAGAAAAGAGAAAAGAAAAAATTGTCTTTGAAAATGAAGATTGTTGTGCCTACTGAGAGTGTTGCACACGAGCCGATCAATATAGATACCACATCGGACACGGTGCCCACGCCTGAACCAACCCTCAACACAGTTGCTTTAGAAGACGGATACGTCTACGTCGGTTCACTCAAAGTTCAAATAATCGAGAACCTGCTTCGATGTCCAGCGGAAGGTTGCTTCAAGAATTTCCGAAACAACACACTGCTACAGATGCATATTAAACATTACCATAGAGAGCTAAGAGAAATGTTAGGAGATACTCCGAAGGTCTTGGACTTGGCATACGCCAGGACAATGCCAGTAGACCCTGACCCGCCGAAACAAGTCGATTCTAAGGTCATTAAGGTCAAAATACCAAAACCACCGAAACGTGAAGAGCCGAAACGAGTCGAACTAGAACCTTTGGACATCAAACCTGATTTAATACTTGATACCGCTCCCAAAACACCAGTTAGCCATGAGGGGGATAGTATTCCGAAACTGCAAGATTCTCCTAAGTTACGCGATGCGTTGATCAACAAGCCAGTGAAGAGACCAAGGGTCTTACTGCCAGTAAGAAGACCAGAGTTTGACCCAGAACCAACTAACATCGAAGATTATGATGCGGTGTTACCAGAGATTCCACCAGAGAGCAGTATGATAGATGTGTTAGATTTCGAAACGGCGATATCGACGCACACCGTGACTAAACCGTTTTCGGAGAAGCGGAAGAAAGGGGACAAGAAGCGGAATTCGTTGACGCTGATGCCTCAGAAGTTGAGCGAAGATGAGGAGTGGTTCGCGGCGACTTCTGATGTGGAGACGAGGTCTAGTTTCCCTCGGTCTGGTACGCCTGACTCTAAGATGGCGGAGGTGCCACCGATGCAGGAGGTAGGCGCCATGTCCGCGGAGTCTAATGAGGAACAAAAGGATTCTCACAAGTACATGTATAATGAGAACGGCGAGCGCGTGAAGATCGTTCACATGAAGCGCGAGGAAATCATCAACTGCCACTGCGGCTATCGCGAGGAGGACGGGCTCATGGTGCAGTGCGAGTTGTGTCTGTGCTGGCAGCACGCGCTCTGCCACAACATACATAGCGAGGCCCAGGTCCCAGAAAAGTACACATGCAGTATTTGCCTGAACCCCCGTCGCGGTCGTCGCTCGCAGCGGTTCCTTCACGACCAGGACCGTCTGTACGAGGGGCTGCTGCCGGGGGCGAAGCCCTGCGACATGCTGCGGCGCTCGCACGAGCTGTCCGGCAACCTGCTGCGCATACAGGACGCACTGCACGCGCTCAGGGTCAAGTGCTATGTTGCTAGCAAAAAAGACCACCCGAAGCTATACCTGTGGGCGAAAGACTGGGAGCATGCAGAGTTGTCGTACACGCAGGAGAAACTCAATTCTGACTACACGGATCTCAACATAATGATCAACAGCGTCGGCAAGGAGAACATGCCCATCAAGCCCGAGGACATCAAGGATATGCAGCTCGACGTCAGGGGCACGCTGTGTGATGACCAGGACTCTGATAGGTTCTCGCAGCGGACGGATAGTCAACTGAGTAATGTGTTGTTGAACAACTTGCTGTCGAGTCCAGGCGGCGCGTCACTGGATCTGCCCATAAGCACCTCAGAGCTGGAGACACTTGCCAAATCTGTTCAAGAGCAAGTGTGCTTGGGCGGGGTGGGGTGCGCGCCGCAGCCCGAGGCGGCCATCGAGAACGGCGCGTGCCGCGTGCGCCTGCTGCGCCACCTGCAGCGCTGCCACGCGCTCGTCGACGCGCGGCTCGACTCCATCGAGGCGCAGGTCGCAGAATTGGAATCTCAAGATCCGTCGTTCGAGGACGACGAGACACCGGACTTTTTCCCGCGAACGAAACACACTGTGCAGATGTTACTACGAGATCTGGACACCATGGAAGAACTTGGAGTCATCACTTAA
Protein Sequence: MAVKQCCIENCKSCSSRKEDNGVTYHKFPKDPALRNIWKSITCCNDSDLPKFVCSRHFYKNDFQMYKDSKYILKSDAVPSIFPWTMTKIVDTTAMETVGSVLENAKTSTSDANKLNTSNSSKDSEENVEAIKQFIEDQEKEFQEKNDAANIVKMENIKNEPANKDVKIENVKETIAVASSVMDMILSESEAKIEKKHEIAPAPKYSISPADKFTSGSISLSVGSRIEAKDFSEEWHPAEIVEVDFDEMEVLVRYEPANKIVSRHDEWISVSSPRLRPLSGTTPKTEVKEETKMPEKEAPVKEEVKEIKQEEKAKVMFAVGERCLARWRDNRRFMATVQKELEDGSYEIIFDDNFKWKCSVSRLYKWKPTGKPELTVETSLNSPTGSASPIQWGGPSTTDAAVNKSAFHTHLFDPTRDYLSSKSERREMKRKLNIKEIFNIGQKRQKTKPDKEVTMSKRPRIIRRSTKVKPKAVVKVEEKVEIKTDIPDAVASIIGTHPKQETIVSEIRIDVEPEIKLEQNIELNKEDIVEDDKKTAVADTQVADDFKMDEYKADLDPVHEEDVKLEKFEKQDDGKHEEVIDRMKEVISKLEVGLIENEKVNSPKVEPKEETPIPVKVDTEIKEVETPKTKEADENGFVDVDGLDAVEPPKPSKKLSKIKKGKKIRLLQEKKVKKQVEIVKKEMEEMRKQVEEMRKQMLRTQELSKGQEMPESFLLPGEWCCKWLNGQPVGAVSEIVCEPRTDSEGKQGLPRRSVQVEDKRLPPGWTKHMVRRSLGHSAGKWDVVLVSPENRRFHTKTDMRNYLENNPDEALKPYEFALMDFGVHLKLSRRMGWISTTPGGVADGPSVSPSIVSCTSPLIKKRKKSEKKREKKKLSLKMKIVVPTESVAHEPINIDTTSDTVPTPEPTLNTVALEDGYVYVGSLKVQIIENLLRCPAEGCFKNFRNNTLLQMHIKHYHRELREMLGDTPKVLDLAYARTMPVDPDPPKQVDSKVIKVKIPKPPKREEPKRVELEPLDIKPDLILDTAPKTPVSHEGDSIPKLQDSPKLRDALINKPVKRPRVLLPVRRPEFDPEPTNIEDYDAVLPEIPPESSMIDVLDFETAISTHTVTKPFSEKRKKGDKKRNSLTLMPQKLSEDEEWFAATSDVETRSSFPRSGTPDSKMAEVPPMQEVGAMSAESNEEQKDSHKYMYNENGERVKIVHMKREEIINCHCGYREEDGLMVQCELCLCWQHALCHNIHSEAQVPEKYTCSICLNPRRGRRSQRFLHDQDRLYEGLLPGAKPCDMLRRSHELSGNLLRIQDALHALRVKCYVASKKDHPKLYLWAKDWEHAELSYTQEKLNSDYTDLNIMINSVGKENMPIKPEDIKDMQLDVRGTLCDDQDSDRFSQRTDSQLSNVLLNNLLSSPGGASLDLPISTSELETLAKSVQEQVCLGGVGCAPQPEAAIENGACRVRLLRHLQRCHALVDARLDSIEAQVAELESQDPSFEDDETPDFFPRTKHTVQMLLRDLDTMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00428145;
90% Identity: iTF_00428145;
80% Identity: iTF_00429082;