Dtem019439.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Dasypolia templi
Gene Symbol
MBD-R2
Assembly
GCA_963555695.1
Location
OY743144.1:10763976-10776439[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.1e-15 6e-12 46.7 0.0 5 58 743 796 739 857 0.87

Sequence Information

Coding Sequence
ATGGCTGTAAAAAAATGTTGCATTCGCGACTGTAAGTCATGTTCTACAAGAAAGGAGGATAAAGGTGTAACATACCACAAGTTTCCAAAGAATGTtgcattatttgacatttggaTAACCGTAACACATAAAAGTCACACAGACACAGAGTTGCCCAAATTTGTGTGCTCGCGGCATTTCTGTAAAAATGATTTTCAAAGTTTCAAGGACTCTAAATACAAATTGAGAACAGACGCGATTCCCTCAATATTTCCATGGGATTCTGACACTGATGAAGAAATGGAAGACATAACTGCCCCAGTGGAAGGTTTTAGTAAAGATTGTGAGGTTGAGAATGTGGATGCCATAAAGAAATTCATTGAAGCACAAGAGAAAGAGATACAGGACCAAAGAGAAGCAGATATTCAGACTAGTGAGAAAAATAAGGATGCAGATGTTAATAAGCCAAGTCAGGAAGAGACACTATGTGTGGCCAGCAGTGTGATAGATATGATACTCAATGAGTCTGAGCTAGAGATTGCTAGGAAGAAAGATGTCGCAAGTAAGGAGATTTTTAGTCCTTTGGACAAAGGTAACAGCAGTATGGCACTCTCCATTGGTTCTAAAGTTGAGGTTAAAGACTTTGGAGATGAATGGCATCCTGCAGATATAAAAGAAGTCGACTATGAAGATATGGAAGTGCTCATACAATATATTGATATAAAACGACTTGACGAATGGATAAGCGTGAGCAGTCCACGCTTACGCCCGGTCAATTCATCTGCTGCCAGTAGTGTGACAACTACAACCACGGTGAAGCCCGGTCCTAGCTCCGAGGAAAGCGTTACTGATATTATACCGATAGCCAATTTGAAAGAGGAACCTAAAGATGTAAAGGTTGAAGAGAAGAGTAGGCTGAGCTTCGCGGTAGGCGAGCGATGCCTCGCGAGGTGGCGCGATAATCGACGCTTTATAGCGACAATTCTTAGGGATTTGGGGGATGgtAATTACGAGATAGTATTCGATGATGGTTGCCATTGGACGTGTAACACGAGTAGGCTTCATAAACTGCGCTCGAAGGCGGGTGAAGTAGACGCGACGTCGGCCCCCCTCACGTACGGCGCGGGCCCTAGCAACACCACcccacaaacaaacacacagtTCCCCAGCCCTGCCTTCCACACACATCTCTTCGATCCCACAAGAGACTACTTAGGATCAAAAAGCGAACGCCGTGAAATGAAACGTAAACTTAACATAAAAGAAATATTCAATATAGGACAGAAAAAGTCGCGTAAGGAGAAGATTGAGAATGAAAAGTTGCAGAAGACAGTTGTAAGGAAACCAAGGATTCTGAAgaagagaagagagaaggtggtcAAGTTGAAGCTTGAAAGTGAAGTGAAGACTGAGATAAAGACTGAACTACCTGCCGTAGATGCCGTAGCTTCCATCATTGGTACTGTAAGCCAAGAGGAACCAATACCTCTGGAAGTTAAGAATGAATTGGAGGAAGATGAGAAACCAGAACCAGTCCTGGAGGATACTAAGGAGGAAGTAGAACAAGGAACCACTGACACGACGAATAAAGAAGTGACTTTGTCTGTAGAACCTCATACCACTATTGAAAATGAAGACCTTATTCAGTTAGAAGACCTGAAAGGTGAACTAGACCAGGTACTCGACGAGGAAGTGAAACTCGAACAATTCGAGAAACCAGACGACGTCAGACACGAGGAAGTTATTGACAGAATCAAAGAGGTCATCAACAAACTAGAGGATGGTCTGAACAACGTCGATAAGGTCGGCTCACCCAAGCTAGAGCCTTCACCCAAGCTAGAACCGAAAGAAGAAATACTGATGTCTCCAGAAATAAAACCAGAACCTAAAGTAGAAGTAAAACAAAAGTCAGAAGAGGTGACTGAACCAAAAGATAGAAGTAAGAAATTATCAAAGATAAAGAAGGGTAAGAAATTGCGGATGTTACGCGAGAAGAAAGTGAAGAAACAAGTGGAGAAGGTGAAGAGTGAGCTGGAGATGATGAAGAAGCAGATGGACGAGATGCGGCAGCAGATGCTGAAGGGGCAGGAGTTTGGGAAAGGCGTGGCTATGCCGGAGTCATTCCTGTTGCCGGGCGAATGGTGCTGCCACTGGGTGAATGGCCAGCCTGTGGGCGCCGTGAGTGAGATCGAGTGCGAGCCCAGGAGCGAGCCAGGTGCACAGGCGCCGCTGCCCAGGAGGAGTGTGCAGGTCGAAGACAAAAGACTACCAGAGGGTTGGACCAAGCACATGGTTCGTAGGAGCTTCGGGCATTCTGCAGGCAAATGGGATGTTGTGTTAGTTAGCCCTGACAACCGCAGATTCCACACAAAGAACGAAATGCGTCTATACTTAGAGAACAAGCCAGAACTCATGGAGCAAGGGTACGAACACGCGCTCACAGACTTCGGCGTGCACCTTAAGATGGCGCGGCGCCTCGGCTGGATCTCGCACACGCCCGACGGAGCCCCGGGCGCCGCCCCCCTGATGCCCGGCACGCTCAGCAGCACCTCGCCTCTCGTCAAGCGAAGGAAGTTGAGTCTTAAGAAGAGAGATAGAGATAGTAAAGACAAGGGGAGGAGGCCCAGGATAACTATCAAGATGAAGGTGACGAAAGATTACTCGGAAGACACGGTGCCTTCTCCAGGTAGTTTAAGCGTCACTGACAGTATTCCTGGGGAAGCTTACCTCGATGCGCCGCCATTAGAAGATGGATATGTATACGTGGGCTCGCTGAAAGTGCAAATAATCGATAACCTTCTTCGTTGTCCGGCTGAGGGTTGCATCAAAAACTTCCGAAACAACACTTTACTACAGATGCATATCAAACACTATCACAAAGAACTCAGAAAGATGATGGGAGCGACGCCTAAAGTGTTAGACTTAGCGTACGCAAGAACCAAGCCGGTGGGCGTGGAAACTCCTCGCGCTAAAGATGACAGGGTCATCAAAGTGAAGATACCTCGACCAGCGAAACGTGAGGAACTCAAACCAGAAGTAAAGGATATTCAAACTGAATTACATGTGGATACAACACCCCTCACGCCAGTCAAAGATAACGTTAGCATAACTGTGCCCAGGAGTCAGGACTCGCCCAAACTGCGGCGGGCTCTCATCAACAAGCCTGTGAAGCGACCAAGAGTATTACTACCCGTTCGAAGACCAGAACCCGAGCAGGTCCTTCCAGACCCTATGAACGAAGAAATTGATGCTGAAGACACCGACCCTACAGAACCTGTCATAGAAATACCAGCATTAGATATGCCGTTAGACTTCGAGAGTGCTATATCAACGCATACTGTGACCAAGCCTGTGTTTGAGAGGAAGCGTAGAGGCGATAAGCGTCGTAAGACCTTCGCGCTGGCTGCTAAGAGGCCAGCTAGTGAAGAAGACGACTGGTTTGGGGCGAACTCGGACTTTGAATCCAGGTCTAGTTTCCCCAGGTCTGGAACACCTGACTCGAAGGTCGATTGTAAAATGGCGCCTGTGTCCTCGGAGTCTaatgaggagattaaggacccTCATATGTATATGTTTACTGAGAACGGCGAGAGGATAAAGATAGTGCACATGAAACGCGAGGAGATCATCAACTGTCACTGCGGGTTCCGCGAGGAGGACGGGCTCATGGTGCAGTGTGAACTGTGCCTGTGCTGGCAACATGCCATGTGCCACAACATACAGCGGGAGTGTGACGTTCCAGAAAAATACACCTGCAGCATCTGCCTTAACCCTCGCCGCGGTCGTCGGTCGCAGCGGTTCCTGCACGACCAAGACCGCATGTACGAGGGTCTGCTGCCGGCCGGCAAGCCGTGCGAGACGTTACGACGCTCGCACGAGGTTGCCGGCAATCTGCTGAGGATCGAGGATGCTCTCCATGCGCTGAGGGTCAAGTACTATGTGGCTACCAAGAAAGACCATCCTAAACTCTACCTCTGGGCCAAAGACTGGGAGCAAGTGGAGATCCAGTACACGCAGGAGAAGCTGAACTCGGACTACTCGGACCTGAACATCATGATCAACAGCATGAACAAGGAGAACCAGCCCCTTAGGCCGGACGACGTGAAGGACTTGCCGCTGGACATACGCGCCCCGACCTTTGATGAACAGGAACATGAGAGGTACACACAAAGTTCCCAGCTCAGTTCCCACAACCTACTGAGTGGCCTAATGTCAAGCCCTGGCGGAGCGTCACTTGACCTGCCTATCAGCACGTCGGAGTTGGAACGACTGGCTAAGACTGTTCAAGAGCAAGAAGCCCAGTGTGCCGTAATCTCGGCCCCGCAGCCCGAGGCGCCGATAGAGAATGCGGCGTGTCGCCGACAACTATTGAAGCACCTGCAGCGTTGCCAAGCGCTCATCGACGCTAGGCTTGACTCTATCGAAGCGCAAGTAGCAGAACTAGAATCTCAAGACCCTTCATTTGAGGACGACGAGACAGCGGACTACTTCCCGCGCACCAAACAGACGGTACAGATGCTGTTGAGAGATCTGGATACAATGGAGGAGCTAGGAGTCATTACTTAA
Protein Sequence
MAVKKCCIRDCKSCSTRKEDKGVTYHKFPKNVALFDIWITVTHKSHTDTELPKFVCSRHFCKNDFQSFKDSKYKLRTDAIPSIFPWDSDTDEEMEDITAPVEGFSKDCEVENVDAIKKFIEAQEKEIQDQREADIQTSEKNKDADVNKPSQEETLCVASSVIDMILNESELEIARKKDVASKEIFSPLDKGNSSMALSIGSKVEVKDFGDEWHPADIKEVDYEDMEVLIQYIDIKRLDEWISVSSPRLRPVNSSAASSVTTTTTVKPGPSSEESVTDIIPIANLKEEPKDVKVEEKSRLSFAVGERCLARWRDNRRFIATILRDLGDGNYEIVFDDGCHWTCNTSRLHKLRSKAGEVDATSAPLTYGAGPSNTTPQTNTQFPSPAFHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKSRKEKIENEKLQKTVVRKPRILKKRREKVVKLKLESEVKTEIKTELPAVDAVASIIGTVSQEEPIPLEVKNELEEDEKPEPVLEDTKEEVEQGTTDTTNKEVTLSVEPHTTIENEDLIQLEDLKGELDQVLDEEVKLEQFEKPDDVRHEEVIDRIKEVINKLEDGLNNVDKVGSPKLEPSPKLEPKEEILMSPEIKPEPKVEVKQKSEEVTEPKDRSKKLSKIKKGKKLRMLREKKVKKQVEKVKSELEMMKKQMDEMRQQMLKGQEFGKGVAMPESFLLPGEWCCHWVNGQPVGAVSEIECEPRSEPGAQAPLPRRSVQVEDKRLPEGWTKHMVRRSFGHSAGKWDVVLVSPDNRRFHTKNEMRLYLENKPELMEQGYEHALTDFGVHLKMARRLGWISHTPDGAPGAAPLMPGTLSSTSPLVKRRKLSLKKRDRDSKDKGRRPRITIKMKVTKDYSEDTVPSPGSLSVTDSIPGEAYLDAPPLEDGYVYVGSLKVQIIDNLLRCPAEGCIKNFRNNTLLQMHIKHYHKELRKMMGATPKVLDLAYARTKPVGVETPRAKDDRVIKVKIPRPAKREELKPEVKDIQTELHVDTTPLTPVKDNVSITVPRSQDSPKLRRALINKPVKRPRVLLPVRRPEPEQVLPDPMNEEIDAEDTDPTEPVIEIPALDMPLDFESAISTHTVTKPVFERKRRGDKRRKTFALAAKRPASEEDDWFGANSDFESRSSFPRSGTPDSKVDCKMAPVSSESNEEIKDPHMYMFTENGERIKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHAMCHNIQRECDVPEKYTCSICLNPRRGRRSQRFLHDQDRMYEGLLPAGKPCETLRRSHEVAGNLLRIEDALHALRVKYYVATKKDHPKLYLWAKDWEQVEIQYTQEKLNSDYSDLNIMINSMNKENQPLRPDDVKDLPLDIRAPTFDEQEHERYTQSSQLSSHNLLSGLMSSPGGASLDLPISTSELERLAKTVQEQEAQCAVISAPQPEAPIENAACRRQLLKHLQRCQALIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTVQMLLRDLDTMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00425469; iTF_01118337; iTF_01118393; iTF_01119407; iTF_01119358; iTF_01117239; iTF_00111741; iTF_00111690; iTF_01093186; iTF_01093124; iTF_01094122; iTF_01094063; iTF_00924781; iTF_00924706; iTF_01094943; iTF_01095010; iTF_01526115; iTF_00036805; iTF_00036746; iTF_01526045; iTF_00906178; iTF_00907909; iTF_00907120; iTF_00907069; iTF_00906240; iTF_00907968; iTF_00809219; iTF_00809163; iTF_01192740; iTF_01192796; iTF_00037894; iTF_00037840; iTF_00810092; iTF_00810147; iTF_00364050; iTF_00364104; iTF_00274452; iTF_00274504; iTF_00043525; iTF_00043524; iTF_00043599; iTF_00043600; iTF_00039836; iTF_00039904; iTF_00040840; iTF_00040915; iTF_00041800; iTF_00041874; iTF_00042715; iTF_00042658; iTF_00951911; iTF_00951859; iTF_00124296; iTF_00124351; iTF_00123401; iTF_00123461; iTF_00726474; iTF_00726385; iTF_00120581; iTF_01247085; iTF_00120533; iTF_01247007; iTF_00374224; iTF_00374142; iTF_01527350; iTF_01527253; iTF_00622903; iTF_00622851; iTF_00147482; iTF_00147545; iTF_00851882; iTF_00851825; iTF_00300292; iTF_00300239; iTF_01029291; iTF_01029345; iTF_00038861; iTF_00038797; iTF_00831248; iTF_00831302; iTF_01026302; iTF_01026213; iTF_00449131; iTF_00375245; iTF_01085261; iTF_01084289; iTF_01085329; iTF_01084343; iTF_01441165; iTF_01441119; iTF_00173056; iTF_00172984; iTF_00771950; iTF_00772006; iTF_00758191; iTF_00758277; iTF_00850831; iTF_00850769; iTF_01031216; iTF_01031167; iTF_01338864; iTF_01338783; iTF_01340136; iTF_00667602; iTF_00667509; iTF_00122421; iTF_00122485; iTF_01440021; iTF_01439959; iTF_01027350; iTF_01027406; iTF_01030317; iTF_01030261; iTF_01028374; iTF_01028317; iTF_00273624; iTF_00273679; iTF_00121466; iTF_00121524; iTF_00745722; iTF_00745810; iTF_01534010; iTF_01533957; iTF_00071453; iTF_00071514; iTF_00237600; iTF_00237703; iTF_00302208; iTF_00302133; iTF_00973856; iTF_00973808;
90% Identity
iTF_00425469; iTF_00906178; iTF_00907909; iTF_00907120; iTF_00907069; iTF_00906240; iTF_00907968; iTF_01093186; iTF_01093124; iTF_01095010; iTF_01094943; iTF_00123461; iTF_00123401; iTF_00237703; iTF_00237600; iTF_00124296; iTF_00124351; iTF_01094122; iTF_01094063; iTF_00924781; iTF_00924706; iTF_00758191; iTF_00758277; iTF_00726385; iTF_00726474; iTF_00122485; iTF_00122421; iTF_00667509; iTF_00667602; iTF_01527253; iTF_01527350; iTF_00622903; iTF_00622851; iTF_00071514; iTF_00071453; iTF_00121466; iTF_00121524; iTF_00745722; iTF_00745810;
80% Identity
iTF_00425469;