Aocu002661.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Amphipoea oculea
Gene Symbol
MBD-R2
Assembly
GCA_945859585.1
Location
CAMAOF010000017.1:1120507-1135516[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 4.4e-16 3.4e-12 46.1 0.0 5 59 748 806 744 866 0.82

Sequence Information

Coding Sequence
ATGGCTGTAAAAAAATGTTGCATTGACCACTGTAAGTCATGTTCAACGAGAAAGGAGGATAAAGGTGTAACATACCACAAGTTTCCAAAAAATGTTGCATTACGTGACATTTGGATAACCGTAACACATAATAAACACACAGACACAGAGTTGCCTAAGTTTGTGTGCTCGCGGCATTTCTGTAAAAATGATTTTCAAAGTTTCAAGGACTCTAAATACAAATTGAGAACAGAAGCGATTCCATCAATATTTCCATGGGATTCTGACACTGATGAAGAAATGGAAGATATAACTGCCCCAGTGGAAGGTTTTAGCAAAGATTGTGAGGTTGAGAATGTGGATGCTATAAAGAAGTTTATTGAAGCACAAGAGAAGGAGATACAGGACCAGAGAGAAGCAGATATTCAGACCATTGAGGAAAATAAGGGTGTAGATGTTAATAAGCCAAGTCAGGAAGAAACACTATGTGTGGCCAGCAGTGTTATAGATATGATACTCAATGAGTCTGAGCTCGAGATTGCTAAAAAGAAAGATGTTGCAAGTAAGGAGATTTTAAGTCCTGTGGACAAAGGTAACAGCAGTATGGCACTCTCCATTGGTTCTAAAGTCGAGGTTAAGGACTTCGGAGATGAATGGCATCCTGCAGATATTGTAGAAGTTGACTATGAGGATATGGAAGTGCTCATACATTGTATTGATATAAAAAGACACGACGAATGGATAAGCGTGAGCAGTCCACGCTTACGCCCGGTCAATTTATCCGCTGCCAGTAGCGTCACAACTACAACCAGTACAACCACGGTGAAGCCTGGTCCTAGTTCCGAGGAAAGCCTTACTGATACTATACCGATAGCCAGTTTGAAAGAGGAGTCCAAAGATGTAAAGGTTGAAGAGAAGAGTAGGCTGAGCTACGCGGTGGGCGAGCGATGCCTCGCGAGGTGGCGCGATAATCGACGCTTTATAGCGACTATTCTTAGAGATTTGGGGGATGGCAATTTCGAGATAGTATTCGATGATGGTTGCCATTGGACGTGTAACACGAGTAGGCTTCATAAATTGCGCACGAAGGCGGGCGATGTTGACGCGACGTCGGCGCCCCTCACTTACGGCGCTGGGCCTAGCAACACCACCCCACAAACAAACACACAGTTCCCTAGCCCTGCTTTCCACACACATCTTTTCGATCCAACAAGAGACTACTTAGGATCAAAAAGCGAACGCCGCGAAATGAAACGCAAACTTAACATAAAAGAAATATTCAATATAGGACAGAAAAAGTCGCGTAAGGAGAAGATTGAAAAGGAAAAGACGCAGAAAACAATCGAAAGGAAACCAAGGATTCTAAAGAAGAGAAGAGAGAAGGTGGTCAAGTTGAAGCTTGAGAGTGAAATGAAAACTGAGATAAAGACTGAACTACCTGCCGTAGATGCCGTAGCTTCCATCATTGGTACTGTAAGCCAAGAGGAACCAGTCCCCCTGGAAGTTAAAGAAGATTTGGAGGAAGATGAGAAACCAGAACCAGTCCTGGAGCAGGAAGTAACCAAGGAGGATGTAGAACAAGGAACCACTAACATGACGAATGAAGAAGTGACTTTGCCTGCAGAGCCTCAAACCAGTATTGATAATGAAGACCTTATTCAGTTGGAAGATCTGAAAGGTGAACTGGACCCGGTACTCGACGAGGAAGTGAAACTCGAACAATTCGAGAAACCAGACGACGTTAGACACGAGGAAGTTATTGACAGAATCAAAGAGGTCATCAACAAACTAGAGGATGGTCTGAACAATGTCGAAAAGGTGGGCTCACCCAAGCTAGAAGCCTCACCCAAGCTAGAACTGAAAGAAGAAATGCTGAAATCTCCAGAAATAAAACCAGAACCAAAAGTAGAAGTTAAGCAAGAGTCACAAAAGGTGACTGGTCCAAAGGATAGAAGTAAGAAATTATCAAAGGTAAAGAAGGTTAAGAAGTTGCGGATGTTACGCGAGAAGAAAGTGAAGAAGCAAGTGGAGAAGGTGAAGAGTGAGCTAGAGTTGATGAGGAAAGAAATGGAGGAGATGCGGGAGGAGATCCTGAAGGAGAAGGCGTTAGGGAAAGACGTGGCGATGCCGAAGTCGTTCCTGATGCCGGGCGAGTGGTGCTGCCACTGGTTGAATGGCCAGCCTGTGGGTGCTGTGAGCGAGATCGAGTGCGAACCCAGGGGGGAGCCCGGGGCTCAGGCGCCGCTGCCTAGGAGGAGTGTGCAGGTCGAAGACAAAAGATTACCAGAGGGTTGGACCAAGCACATGGTTCGTAGGAGCTTCGGGCATTCTGCAGGCAAATGGGACGTCGTGTTAGTTAGCCCCGACAACCGCAGATTCCACACGAAGAACGAAATGCGTCTATACTTAGAGAACATGCCAGAACTTAGGACGCTAGGGTACGAACCCGCGCTCACAGACTTCGGTGTGCACCTAAAGCTGGCGCGGCGCCTCGGCTGGATCTCGCACACGCCCGACGGAGCCCCGAGCGCCGCCCTCCTGCCGTCTGGCACGCTCAGCAGCACGTCGCCGCTCGTCAAGCGAAGGAAGTTGAGTCTTAAGAAGAAGAGAGACAGGGATAGTAAGGTCAAGGAGAGGAGGCCCAGGATAACTATTAAGATGAAGGTGCCGAAAGATAACGCACACTCAGAAGACAATGTGCCATCTCCAGGTAGTTTAAGCGTCAGTGACAGTATTCCTGGCGAAGGTTACCTCGATGCGCCGCCATTAGAAGATGGATATGTATACGTGGGTTCGCTAAAAGTGCAAATAATCGAGAACCTTCTTCGTTGTCCGGCTGAGGGATGCTTCAAAAACTTCCGGAACAACACTTTACTACAGATGCATATCAAACACTATCACAAAGAGCTCAGAAAGTTGATGGGAGCGACTCCTAAAGTGCTAGACTTAGCGTATGCAAGAACCAGGCCGGTGGGGGTGGAAACTCCTCGCTCTAAAGATGACAGGATCATCAAAGTGAAGATACCTCGACCTCCCAAACGGGAAGAACCTAAACCAGAAGTAAAGGACATTCAAACTGAATTACAAGTGGATACAACTCCCTTTACGCCGGTCAAAGATGGCGATAGCATAACTGTGCCCAGGAGTCAGGACTCGCCCAAACTGCGGCAGGCTCTCATCAACAAGCCTGTAAAGCGACCACGGGTATTATTACCCGTTCGAAGACCGGAACCGGAGCCGCCCATACCTGATCCTATGAACGAAGAAATAGATGTAGAAGACAGAGAACCTATAGAAACTGTCATAGAAATACCTCCTTTGGAAATACCATTAGACTTCGAGAGTGCTATATCAACGCATACTGTGACCAAGCCTGTCTTTGAAAGGAAGCGTAAAAGCGATAAGCGTCGTAAGACCTTCCTGCTGGCTGCTAAGAGGCCAGCCAGTGAAGAAGAAGACTGGTTTGGAGCGAACTCGGACTTTGAAACCAGGTCCAGTTTCCCCAGGTCTGGAACACCAGACTCGAAGGTTGATTGTAAAGTGGCGCCTGTGTCTTCGGAGTCTAATGAGGAGATTAAGGACGCTCATATGTATATGTTTACTGAGAATGGCGAGAGGATAAAGATAGTACACATGAAACGCGAAGAGATCATCAACTGTCACTGCGGGTTCCGCGAGGAGGATGGGCTCATGGTGCAGTGCGAACTGTGCCTGTGCTGGCAACACGCCATGTGCCACAACATACAGAGGGAGTGTGACGTCCCAGAAAAATACACATGCAGCATCTGCCTAAATCCTCGCCGCGGTCGTCGGTCGCAGCGGTTCCTGCACGACCAGGACCGAATGTATGAAGGTCTACTGCCGGCTGGCAAGCCGTGCGAGACGTTACGACGCTCGCACGAGGTGGCCGGAAATCTGCTCAGGATCGAGGATGCTCTCCATGCGCTGAGGGTCAAGTACTATGTGGCTACCAAGAAAGACCACCCAAAACTCTACCTCTGGGCCAAAGACTGGGAGCAGGTGGAGATCCAGTACACGCAGGAGAAGCTGAACTCTGACTACTCGGACCTGAACATCATGATCAACAGCATGGACAAGGAGAACCAGCCGCTGCAGCCGGACGACGTGAAGGACTTGCCGCTGGACATACGCGCCCCGACCTTTGATGATGAGAGGTACACACAAAGTTCCCAGCTCAGTTCCCACACCCTACTGAGTGGCCTAATGTCAAGTCCGGGCGGAGAGTCACTGGACCTGCCTATCAGTACGTTGGAGTTGGAACGACTCGCCAAGTCTGTTCAAGAGCAAGAAGCCCAGCGTACCGTAATCTCGGCCCCACAGCCCGAGGCACCGATAGAGAATGCGGCGTGTCGCCGACAACTGTTGAAGCACCTGCAGCGTTGCCAAGCGCTCATTGACGCTAGGCTTGACTCCATCGAAGCACAGGTTGCAGAACTAGAATCTCAAGACCCGTCATTTGAGGACGATGAGACAGCGGACTACTTCCCGCGCACCAAACAGACGGTACAGATGCTGATGCGAGATCTGGATACAATGGAGGAGCTGGGAGTCATTACCTAA
Protein Sequence
MAVKKCCIDHCKSCSTRKEDKGVTYHKFPKNVALRDIWITVTHNKHTDTELPKFVCSRHFCKNDFQSFKDSKYKLRTEAIPSIFPWDSDTDEEMEDITAPVEGFSKDCEVENVDAIKKFIEAQEKEIQDQREADIQTIEENKGVDVNKPSQEETLCVASSVIDMILNESELEIAKKKDVASKEILSPVDKGNSSMALSIGSKVEVKDFGDEWHPADIVEVDYEDMEVLIHCIDIKRHDEWISVSSPRLRPVNLSAASSVTTTTSTTTVKPGPSSEESLTDTIPIASLKEESKDVKVEEKSRLSYAVGERCLARWRDNRRFIATILRDLGDGNFEIVFDDGCHWTCNTSRLHKLRTKAGDVDATSAPLTYGAGPSNTTPQTNTQFPSPAFHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKSRKEKIEKEKTQKTIERKPRILKKRREKVVKLKLESEMKTEIKTELPAVDAVASIIGTVSQEEPVPLEVKEDLEEDEKPEPVLEQEVTKEDVEQGTTNMTNEEVTLPAEPQTSIDNEDLIQLEDLKGELDPVLDEEVKLEQFEKPDDVRHEEVIDRIKEVINKLEDGLNNVEKVGSPKLEASPKLELKEEMLKSPEIKPEPKVEVKQESQKVTGPKDRSKKLSKVKKVKKLRMLREKKVKKQVEKVKSELELMRKEMEEMREEILKEKALGKDVAMPKSFLMPGEWCCHWLNGQPVGAVSEIECEPRGEPGAQAPLPRRSVQVEDKRLPEGWTKHMVRRSFGHSAGKWDVVLVSPDNRRFHTKNEMRLYLENMPELRTLGYEPALTDFGVHLKLARRLGWISHTPDGAPSAALLPSGTLSSTSPLVKRRKLSLKKKRDRDSKVKERRPRITIKMKVPKDNAHSEDNVPSPGSLSVSDSIPGEGYLDAPPLEDGYVYVGSLKVQIIENLLRCPAEGCFKNFRNNTLLQMHIKHYHKELRKLMGATPKVLDLAYARTRPVGVETPRSKDDRIIKVKIPRPPKREEPKPEVKDIQTELQVDTTPFTPVKDGDSITVPRSQDSPKLRQALINKPVKRPRVLLPVRRPEPEPPIPDPMNEEIDVEDREPIETVIEIPPLEIPLDFESAISTHTVTKPVFERKRKSDKRRKTFLLAAKRPASEEEDWFGANSDFETRSSFPRSGTPDSKVDCKVAPVSSESNEEIKDAHMYMFTENGERIKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHAMCHNIQRECDVPEKYTCSICLNPRRGRRSQRFLHDQDRMYEGLLPAGKPCETLRRSHEVAGNLLRIEDALHALRVKYYVATKKDHPKLYLWAKDWEQVEIQYTQEKLNSDYSDLNIMINSMDKENQPLQPDDVKDLPLDIRAPTFDDERYTQSSQLSSHTLLSGLMSSPGGESLDLPISTLELERLAKSVQEQEAQRTVISAPQPEAPIENAACRRQLLKHLQRCQALIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTVQMLMRDLDTMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00425409;
90% Identity
iTF_00425409;
80% Identity
iTF_00071514;