Basic Information

Insect: Gortyna flavago
Gene Symbol: MBD-R2
Assembly: GCA_963669345.1
Location: OY770127.1:15940433-15952196[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 7.6e-16 2.6e-12 46.9 0.0 5 59 763 821 759 881 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	7.6e-16	2.6e-12	46.9	0.0	5	59	763	821	759	881	0.80

Sequence Information

Coding Sequence: ATGGctgtaaaaaaatgttgcaTTGACCACTGTAAGTCATGTTCAACGAGAAAGGAGGATAAAGGTGTAACATACCACAAGTTTCCAAAAAATGTTGCATTATGTGACATTTGGATAACAGTAACACATAACAAACACACAGACACAGAGTTGCCTAAGTTTGTGTGCTCACGGCATTTCTGTAAAAATGATTTTCAAAGTATCAAGGACTCTAAATACAAATTGAGAACAGACGCGATTCCATCAATATTTCCATGGGATTCTGACACTGATGAAGAAATGGAAGATTTAACTGCTCCAGTGGAAGGTTTTAGCAAAGATTGTGAGATTGAGAATGTGGATGCTATAAAGAAGTTTATTGAAGCACAAGAGAAAGAGATACAGGACCAGAGAGAAGCAGATATTCAGACTATTGAGAAAGAGAAACAGGACCAGAGAGAATCAGATATTCAGACTATTGAGAAAAGTAACGATGTAGATGTTAATAAGCCAAGTCAGGAAGAAACACTATGTGTGGCCAGCAGTGTTATAGATATGATACTCAATGAATCTGAGCTCGAGATTGCTAAAAAGAAAGATGTAGCAAGTAAGGAGATTTTTAGTGCTGTGGACAAAGGTAACAGCAGTATGGCACTCTCCATTGGTTCTAAAGTCGAGGTTAAGGACTTCGGAGATGAATGGCATCCTGCAGATATTGTAGAAGTCGACTATGAGGAAATGGAAGTGCTCATACATTGTATTGATATAAAAAGACACGACGAATGGATAAGCGTGAGCAGTCCACGCTTACGCCCGGTCTATTCGTCCGCTGCCAGTAGCGTCACAACTACAACCATTACAACCACGGTGAAGCCTGGCCCTAGTTCCGAGGAAAGCCTTACTGATACTATACCGATAGCCAGTTTGAAAGAGGAGTCCAAAGATGTAAAGGTTGAAGAGAAGAGTAGGCTGATCTATGCGGTGGGCGAGCGATGCCTCGCGAGGTGGCGCGATAATCGACGCTTTATAGCGACTATTCTTAGAGATTTGGGGGATGgcAATTTCGAGATAGTATTCGATGATGGTTGCCATTGGACATGTAACACGAGTAGGCTTCATAAACTGCGCTCGAAGGCGGGCGATGTTGACGCGACGTCGGCGCCCCTCACGTACGGCGCCGGGCCTAGCAACACCACcccacaaacaaacacacagttCCCTAGCCCTGCCTTCCACACACATCTCTTCGATCCCACAAGAGACTACTTAGGATCAAAAAGCGAACGCCGCGAAATGAAACGAAAACTTAACATAAAAGAAATATTCAATATAGGACAGAAAAAGTCGCGTAAGGAGAAGATTCAGAAGGAAAAGACGCAGAAAACGATCGAAAGGAAACCAAGGATTCTGAAGAAGAGAAGAGAGAAGGTGGTCAAGATGAAGCTTGAGTGTGAAGTGAGGACCGAGATAAAGTCTGAACTACCTGccGTAGATGCCGTAGCTTCCATCATTGGTACTGTAAGCCAAGAGGAACCAGTACCTCTGGAAGTTAAGAAAGATTTGGAGGAAGATGAGAAACCAGAACCAGTCCTGGAGGAGGAACTAACCAAGCAGGAAGTAGAACAAGGAGCCACTGACATGACAAATGAAGAAGTGAATTTGCCTGCACAGCCTCACACCAGTTTTGATAATGAAGATCTTATTCAGTTGGAAGACCTGAAAGGTGAACTAGACCCGgtactcgACGAGGAAGTGGAACTCGAACAATTCGAGAAACCAGACGACGTCAGACACGAGGAAGTTATTGACAGAATCAAAGAGGTCATCAACAAACTAGAGGATGGTCTGAATAACGTCGAAAAGGTGGGCTCACCCAAGCTAGAACCCTCACCCAAGCTAGAACCGAAAGAAGAAATGCTGACATCTCCAGAAATAAAACCAGAACCAGAAGTACAAGTTAAGCAAAAGACAGAAGAGGTGACTGATCCAAAAGATAGAAGTAAGAAGTTATCAAAGGTAAAGAAAGGTAAGAAGTTGCGGTTGTTACGCGAGAAGAAAGTGAAGAAGCAAGTGGAGAAGGTGAAGAGTGAGCTGGAGATGATGAGGAAGCAAATGGACGAGATGCGGGAGCAGATGCTGAAGGGGCAGGAGTTGGGGAAAGGCGTGGCGATGCCAGAGTCGTTCCTGATGCCGGGCGAGTGGTGCTGCCACTGGGTGAATGGCCAGCCTGTGGGCGCTGTGAGTGAGATCGAGTGCGAGCCCAGGGGGGAGCCGGGGGCTCAGGTGCCGTTGCCTAGGAGGAGTGTGCAGGTCGAAGACAAAAGATTGCCAGAGGGTTGGACCAAGCACATGGTTCGTAGGAGCTTCGGGCATTCTGCAGGCAAATGGGACGTTGTGTTAGTCAGCCCCGACAACCGCAGATTCCACACGAAGAACGAAATGCGTCTATATTTAGAGAACAAGCCAGAACTTATGGAGCAAGGGTACGAACACGCGCTCACAGACTTCGGCGTGCACCTAAAGTTGGCGCGGCGCCTCGGCTGGATCTCGCACACGCCCGACGGAGCCCCGGGCGCCGCCCCCCTGGCGCCCGGCACGCTCAGCAGCACCTCGCCGCTCGTCAAGCGAAGGAAGTTGAGTCTTAAGAAGAAGAGAGACAGAGATAGTAAGGTCAAGGAGAGGAGGCCCAggataactattaaaatgaagATGCCGAAAGTTTACGTACCCTCAGAAGACACTGCGCCATCTCCAGGTAGTTTAAGCGTCAGTGACAGCATTCTTGGTGAAGCTTACCTCGATGCGCCGCCATTAGAAGATGGATATGTATACGTGGGCTCGCTAAAAGTGCAAATAATCGAGAACCTTCTTCGTTGTCCGGCTGAGGGTTGCTTCAAAAACTTCCGAAATAACACTTTACTACAGATGCATATCAAACACTATCACAAAGAGCTCAGAAAGATGATGGGAGCGACTCCGAAAGTGTTAGACTTAGCGTATGCAAGAACCATGCCGGTGGGGGTGGAAACTCCTCGCTCTAAAGACGACAAGATCATCAAAGTGAAGATACCTCGACCACCCAAACGGGAAGAACTCAAACCAGATGTAAAGGACATTCAAACTGAATTACAAGTGGATACAACACCCTTTACGCCGGTCAAAGATGGCGATAGCGTAACTGTGCCCAGGAGTCAGGACTCGCCTAAACTGCGGCAGGCTCTCATCAACAAGCCTGTGAAGCGACCACGGGTATTATTACCCGTTCGAAGACCGGAACCGGAACCGCCCATACCTGATCCTATGAACGAAGAAATAGATGTAGAAGACAGAGAACCTATAGGAACTGTCATGGAAATACCTGCTTTAGACATACCGTTAGACTTCGAGAGTGCTATATCAACGCATACTGTGACCAAGCCTATGTTTGAGAGGAAGCGTAAAGGCGATAAGCGTCGTAAGACCTTCCTGCTCGCTGCTAAGAGGCCAGCGAGTGAAGAAGAGGACTGGTTTGGAGCGAACTCTGACTTTGAAACCAGGTCCAGTTTCCCCAGGTCTGGAACACCAGACTCGAAGGTTGATTGTAAAGTGGCGCCTGTGTCTTCGGAGTCTAATGAGGAGATTAAGGACGCTCATATGTATATGTTTACTGAGAATGGCGAGAGGATAAAGATTGTGCACATGAAACGCGAAGAGATCATCAACTGCCACTGCGGGTTCCGCGAGGAGGATGGGCTCATGGTGCAGTGCGAACTGTGCTTGTGCTGGCAACACGCCATGTGCCATAACATTCAGAGGGAGTGTGACGTTCCAGAAAAATACACATGCAGCATCTGCCTAAATCCTCGCCGCGGTCGTCGGTCGCAGCGGTTCCTGCACGACCAGGACCGAATGTATGAGGGTCTACTGCCGGGTGGCAAGCCGTGCGAGACTTTACGACGATCGCACGAAGTGGCCGGCAATCTGCTCAGGATCGAGGATGCTCTGCATGCGCTGAGGGTCAAGTACTATGTGGCTACCAAAAAAGACCACCCAAAACTCTACCTCTGGGCCAAAGACTGGGAGCAGGTGGAGATCCAGTACACGCAGGAGAAGCTGAACTCGGACTACTCGGACCTGAACATCATGATCAACAGCATGGACAAGGAGAACCAGCCGCTACGGCCGGACGACATAAAGGACCTGCCGCTGGACATACGCGCCCCGACCTTTGATGAACAGGAACATGAAAGATACACACAAAGTTCCCAGCTCAGTTCCCACACCCTACTGAGTGGCCTAATGTCAAGTCCGGGCGGAGCGTCACTGGACCTGCCTATCAGCACGTCAGAGTTGGAACGACTCGCCAAGTCTGTTCAAGAGCAAGAAGCCCAGCGTACCGTAATCTCGGCCCCGCAGCCCGAGGCGCCGATAGAGAATGCGGCGTGTCGCCGACAGCTGTTGAAGCATCTGCAGCGTTGCCAAGCGCTCATCGACGCTAGGCTTGACTCCATCGAAGCGCAGGTTGCAGAACTAGAATCTCAAGATCCGTCATTtgaggacgacgagacagcggaCTACTTCCCGCGCACCAAACAGACGGTACAGATGCTGATGCGAGACCTGGATACAATGGAGGAGCTGGGAGTCATTACCTAA
Protein Sequence: MAVKKCCIDHCKSCSTRKEDKGVTYHKFPKNVALCDIWITVTHNKHTDTELPKFVCSRHFCKNDFQSIKDSKYKLRTDAIPSIFPWDSDTDEEMEDLTAPVEGFSKDCEIENVDAIKKFIEAQEKEIQDQREADIQTIEKEKQDQRESDIQTIEKSNDVDVNKPSQEETLCVASSVIDMILNESELEIAKKKDVASKEIFSAVDKGNSSMALSIGSKVEVKDFGDEWHPADIVEVDYEEMEVLIHCIDIKRHDEWISVSSPRLRPVYSSAASSVTTTTITTTVKPGPSSEESLTDTIPIASLKEESKDVKVEEKSRLIYAVGERCLARWRDNRRFIATILRDLGDGNFEIVFDDGCHWTCNTSRLHKLRSKAGDVDATSAPLTYGAGPSNTTPQTNTQFPSPAFHTHLFDPTRDYLGSKSERREMKRKLNIKEIFNIGQKKSRKEKIQKEKTQKTIERKPRILKKRREKVVKMKLECEVRTEIKSELPAVDAVASIIGTVSQEEPVPLEVKKDLEEDEKPEPVLEEELTKQEVEQGATDMTNEEVNLPAQPHTSFDNEDLIQLEDLKGELDPVLDEEVELEQFEKPDDVRHEEVIDRIKEVINKLEDGLNNVEKVGSPKLEPSPKLEPKEEMLTSPEIKPEPEVQVKQKTEEVTDPKDRSKKLSKVKKGKKLRLLREKKVKKQVEKVKSELEMMRKQMDEMREQMLKGQELGKGVAMPESFLMPGEWCCHWVNGQPVGAVSEIECEPRGEPGAQVPLPRRSVQVEDKRLPEGWTKHMVRRSFGHSAGKWDVVLVSPDNRRFHTKNEMRLYLENKPELMEQGYEHALTDFGVHLKLARRLGWISHTPDGAPGAAPLAPGTLSSTSPLVKRRKLSLKKKRDRDSKVKERRPRITIKMKMPKVYVPSEDTAPSPGSLSVSDSILGEAYLDAPPLEDGYVYVGSLKVQIIENLLRCPAEGCFKNFRNNTLLQMHIKHYHKELRKMMGATPKVLDLAYARTMPVGVETPRSKDDKIIKVKIPRPPKREELKPDVKDIQTELQVDTTPFTPVKDGDSVTVPRSQDSPKLRQALINKPVKRPRVLLPVRRPEPEPPIPDPMNEEIDVEDREPIGTVMEIPALDIPLDFESAISTHTVTKPMFERKRKGDKRRKTFLLAAKRPASEEEDWFGANSDFETRSSFPRSGTPDSKVDCKVAPVSSESNEEIKDAHMYMFTENGERIKIVHMKREEIINCHCGFREEDGLMVQCELCLCWQHAMCHNIQRECDVPEKYTCSICLNPRRGRRSQRFLHDQDRMYEGLLPGGKPCETLRRSHEVAGNLLRIEDALHALRVKYYVATKKDHPKLYLWAKDWEQVEIQYTQEKLNSDYSDLNIMINSMDKENQPLRPDDIKDLPLDIRAPTFDEQEHERYTQSSQLSSHTLLSGLMSSPGGASLDLPISTSELERLAKSVQEQEAQRTVISAPQPEAPIENAACRRQLLKHLQRCQALIDARLDSIEAQVAELESQDPSFEDDETADYFPRTKQTVQMLMRDLDTMEELGVIT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00425409;
90% Identity: iTF_00425409;
80% Identity: iTF_00758277;