Basic Information

Insect: Anopheles melas
Gene Symbol: L
Assembly: GCA_000473525.2
Location: KI921796.1:2790-8531[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 17 0.69 37 4.9 5.7 1 23 3 25 3 25 0.98

2 17 5.7e-06 0.00031 20.9 3.7 1 23 31 53 31 53 0.99

3 17 1.7e-05 0.00093 19.3 0.3 1 23 59 81 59 81 0.98

4 17 7.5 4e+02 1.6 0.1 2 23 186 209 185 209 0.78

5 17 0.12 6.3 7.3 0.1 2 23 259 281 258 281 0.96

6 17 0.27 15 6.1 0.2 1 23 617 639 617 639 0.95

7 17 7.7 4.1e+02 1.6 0.6 1 23 677 699 677 699 0.90

8 17 0.00037 0.02 15.1 0.2 1 23 746 769 746 769 0.93

9 17 0.0042 0.23 11.8 0.7 1 23 776 799 776 799 0.97

10 17 0.0028 0.15 12.4 1.5 1 23 831 853 831 854 0.96

11 17 0.48 26 5.4 0.2 1 23 1161 1185 1161 1185 0.91

12 17 0.00069 0.037 14.3 0.2 2 23 1194 1216 1193 1216 0.96

13 17 0.0051 0.27 11.6 0.1 1 23 1223 1245 1223 1245 0.98

14 17 2.6 1.4e+02 3.0 1.2 2 20 1253 1271 1253 1274 0.94

15 17 0.0076 0.41 11.0 0.2 1 23 1482 1504 1482 1504 0.96

16 17 0.014 0.75 10.2 0.1 1 20 1514 1533 1514 1537 0.95

17 17 0.042 2.3 8.7 0.3 1 23 1545 1567 1545 1567 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	17	0.69	37	4.9	5.7	1	23	3	25	3	25	0.98
2	17	5.7e-06	0.00031	20.9	3.7	1	23	31	53	31	53	0.99
3	17	1.7e-05	0.00093	19.3	0.3	1	23	59	81	59	81	0.98
4	17	7.5	4e+02	1.6	0.1	2	23	186	209	185	209	0.78
5	17	0.12	6.3	7.3	0.1	2	23	259	281	258	281	0.96
6	17	0.27	15	6.1	0.2	1	23	617	639	617	639	0.95
7	17	7.7	4.1e+02	1.6	0.6	1	23	677	699	677	699	0.90
8	17	0.00037	0.02	15.1	0.2	1	23	746	769	746	769	0.93
9	17	0.0042	0.23	11.8	0.7	1	23	776	799	776	799	0.97
10	17	0.0028	0.15	12.4	1.5	1	23	831	853	831	854	0.96
11	17	0.48	26	5.4	0.2	1	23	1161	1185	1161	1185	0.91
12	17	0.00069	0.037	14.3	0.2	2	23	1194	1216	1193	1216	0.96
13	17	0.0051	0.27	11.6	0.1	1	23	1223	1245	1223	1245	0.98
14	17	2.6	1.4e+02	3.0	1.2	2	20	1253	1271	1253	1274	0.94
15	17	0.0076	0.41	11.0	0.2	1	23	1482	1504	1482	1504	0.96
16	17	0.014	0.75	10.2	0.1	1	20	1514	1533	1514	1537	0.95
17	17	0.042	2.3	8.7	0.3	1	23	1545	1567	1545	1567	0.95

Sequence Information

Coding Sequence: ATGCCATTCAAATGTGAGTACTGTGCCCGACTGTTCAAGCACAAACGATCGCGGGATCGCCATACGAAGCTGCATACCGGCGATCGGCGCTATCGCTGTCTGCACTGCGAGGCTGCATTCTCCCGAAGTGATCATCTGAAGATACACATGAAAACGCACGACAACCAGAAGCCGTTCCAGTGTACGATCTGCAACCGAGGCTACAATACGGCCGCAGCGCTAACGAGTCATATGCAAAATCACAAGAAGCAGCTGGCCCTGACCGGGAGTCCCAACCTTACGTACAGTCCACGCTCCACCACAAGCTCCCTCTCGAGTGGAGGAGGAAGTGGTGGTGGCGGCAAGCGAGGGTCAAAGTTCTCGTCCTACTCCAACGACCCACTGATGCTGATGAGCCGCGGCAACTCCAAACTGTCCTCGTCCCTTTCCAAAGCCGCAAGTATTCGAACTCCAACACCTGGGAGTACGGCCGGCGGTGGTGGCCCTGCAACTCTGGGAGGTGTGGGAAGTGGTGCGGGAGGTGGTACCGGCACCGCCCATCATCAGGATCTACTCTCCTGTCCGTACTGTACGCGCACGGATTTTGGGACGCTCGAACAGCTCGGCCTCCATGTGCAGTCGATGCACGGGCATGGTGGTGCTGGTGCATTGGGATTGCTTGCTGGCGACTCCTCAATGTCTTACTTCACACCTGCCGGTGGACGACGTGCAGTGACACCCGATGGGAGCAACGTCCCGCTCTCACTCGGTGGGCTCAGTCCGTATCCGCCGATTAGCTGCGAGTTCTGCACGATGAAGTTCCCAACCGTTCCGCTCATGTTTGCTCATCTCAAGACGGCTCATCTGGATCGGTTGGCTGGCAGTGGTGGTCATCAACGAAGCTCACCATCGAATGGTACCGGCAGTCCGGTCGGGTCACGTCCTCCCAGTGGGTTCCACCCGCTAGACCAGCTGCACTTTAACAAGAGCCTGCTTGGGAGTGCTTTCCCCTCCTTCTACGGTGGTGGTTCTTCCAACAGCCTTGCCGGAATGTCCGGAGGCAGTATTAAAGCGGAGCGCCGACTAATGGCCGATCGTGATGAAAATGGAAATGAAGAAGAAGCGGGAGGTAGAAAGCGGCAGCGTAGAGGAGACGATGGAGAAGATGTTAGGGGGAGCATGTCGAAACGGGACAAGCAAGAAAGGGAGGAGGACGAAGCTATTGAAGGTGATCAGGAGGACGATGCGGATGATGATAATGATGCTGAGGGAGACGATAATGAGGAGGGAGAAAGTGAGGCTCATGGAGCGAACAATCGATGTGAGGAGTCCGTTGACTACAAGGAAGAAGCGATCGATACGAAGATCACACCGATCAAGCAGGAGCGAAAGGAAGAGCCTGCTGAGGGTGAGCCATCTCCTTCGACTTCTGCACGATCGTCTCCCTGTGGTGATTCCCTGGAATTGGGAAGTGGACGTCCCGGAAGTCATCCATCGGGACGTACAAGTCCTGCAGAGCAACTCACTCCAACAGACCTGAGTCAGCCGAAGATGAAGCGTCTCAAGCTGGAGACGCCCGAAGAAGACCCAGTGACCGACGGGGCGGATAGAAAGAGGATGATGATGACAGCGTCAGCAGCACCTGGAAGATCTCAAACAACACGCGAGCAACACAAACATCGTGGTCCAGGAGCAACCGCAACTGCAGCAAGTCGTCGAGATAGTGAAGCAAAGGACTCAAACTTCCAGCACGGCTCACTGATGCATTCCTCCTCTTCTGGCAGCAACGTCCAACACTCCCACTCCCAGATGGGTGCACCTACTTCGGCTGGATCATCATCCCAGCAGCACCATCAACCTCCCGGCGCATACCTCTGCAATCAATGCAATGCCGCACTGCCCGATTTCGAATCGTTCCGCTCGCACCTCAAGGCACATCTCGAGCAGAGTGCGGCCAGTGCGGCGGCAGCCGCTGCAATGCGACTGTCTGGGGAGCATGTCAATTCGGGCAGTTCCGGAGGCAGTTCATCATCTCTTTCGCTTACGACCTTCCTCTGTCAGCAGTGTGGTGTTACGTTGAGCTGTCAGGCGGAGTACGAACAGCACACGATTGGCCATTTCCTTGTGATGGCGGTCGAGTATCGATGTCAGGGGTCGACCGGAACTGCAGGCCCTGCTAGCTGCAGTGGTAAGAGCACCTTCGGCAAGGTGGAGGACCTTCACAAACATCTGTACGAAGGGCATATGCAACTCCTCTACAAGTGTACGGTTTGTGGGGAGACGTTCGAATCCAAGGTTCAGGTGCAGGTACACTTTGCCGTGAGTCATTCGGTCGAGGTGAAGCTGTACCGCTGCTCAGCCTGTGCTGAAGCGTTCCGTTCGGAGCGTGATTTTAGGCAACACATTCGAAATCGCCACCTGACGGCGGGTGCTGTACAGTGTATGTTTTGCCGGATGGTTTGCTCGTCCGAGCTTGAGATGCACTTTCATCTTGCGTCGCACGCCAGGAAGTATAAATGTCCAGCCTGTCCAGAGTCGTTCCATGTGGAGTTCCTGCTCGATCGGCATATTCAAACGCATCACAGCCAGAAGGAGACGTCCTCACCGAACCGAGGCCGAGAGTCCGCCAACGGTGGCCACAACCTGTCAACTACATCTTCCTGCTCCACCAACTCCACGCCCTCAACGGCCACAGCAGTGCCGTCTACAGCTCAACCGACCTCAACAACAACAACCGTCACCGGGTTGGACTACCTGCACCTACACGGACAAATGGCGGCAATGGCAGCAGCTGCGGCTTGGCCCACTCTGTACCAAACTGCTGCCAACAAGTTCTACAGCAGCAACCCGCTGCAAGTAGACACACTGTCCCAGCTGAAGCATCCACAGCAGCTTCTGCACGGTTTCTACGACACCATGCTCGGTAAAGCGCAAGCGCAACAGCAGCAGCAGCGTGGTGCATTCCTTCCCGAGTCATCCAGCGGTGGCAAGAAGAACCCCTTCGTTGCTGGCCATTCACCTAATGCCAGCGCGAACGCTACTAATGCACTGCTTGGGCTGGGTTATGGAGGAGCATCGCTAACTTCAGGAAACTCCCAACAGCAAAGAACTTCCACGCTTAATGGTTCCTCTTCTGGGCTTTACTCCCCCGAGGAAGGTCCTAATGGTGGGTCGAGTGTGGCCACTAGTAGCTCAAAGCTTTACTCTCCCATTGCCATGATACAGCGGTACGGTGATGGTGTTGCTGGTGTTGCGGCACTGCATTCCACACCTGGTACAGTGCCGCCTACTGTTACCGGATGTTCTTCCCGCACGGAATCTCCTACACCGAGTGGACAGCAACTTCTTCTGGCAGCTCACTCCACGTTAAGTTCACTGCCTGAACATCATCCCGAACAGCAGCAGTCGAGTAATCGAAAGACAGCCCAACCGCAGTCAGCTCCTAAGACATCATCCGGTACAATCACACCACAGCTGATTGCACCCGGCTCGAACAGCTGCTACAGCTGCGGCATCTGCGAACGGTCCGACTTTAGCACGGAGAGTGAGGTCCAAACGCATCGCAAGATTGTGCACAACTTGAAAACGGGCGTTAGTTTGCGGTGTGCGTACTGCAACGGGGACTTTCGGTCGAGAAATGAGCTCGAGAACCACATGAAGGTCGCACACAATACGGGCGGTGGCAAGCACAAGTGTTTGATCTGCGACGAAATCTTCCCATCGCCGGCAGTACTTGCCGAACATAAGCTGACGCACTGTAAAGTGGGTGCTTCGGGACGCTGTTCGCACTGTAGTTTGCCCCTGCCCGATGCTCACACCTTCAAGCAGCATCTGCCGGCTCATCAGCAGATCGGTGGATCATCCTCGGGAACGACAGGAGCAGGCACCACCACAACGACGAATGGATCCTCAAACGGAGGTACGTCTGGTGCGGGTAACTCCTCCACTGGACAGGGTGCGTCTACTTCGGCCGGAGCTAATTCGAGTGGCACCGGGACAAGTTCCAACTCGAATGCGGATCAGGATCGCTTCCCTCAGCAGTGCATCTGTTGCCGGCAAACGCTCAACTCCGAGTTTGAAATTAGTCTTCATGCCAAATTCCACACCAAAACCGCAGAAACTAACGAACGCACGTGTGCTCTCTGCCTGGAGCCGTTACCTTCACAACCCGAGTCCAACACCAAGATCTGTGATCCCTGTCTGAAACGGCACAATTTCCCTACGAAGCTCCTATCGATGAACTTCCTGAAGCCTACCACCTCATCGCTAGTGCCAACACCAACCCACGGTGGATCATCTTCAGCCGGTGTTGTTGTACCACACACTCACGGTACAACCATTGGTAACAGTGTCGCAGTTGAAGGAAGACCACCACTACCACCACCGCCCCCAACATCCTCGGGAAGTCTTCAACAAGACCCACAACACCCGGACGTCGGGCGGGAAGGTTCATCCTCTGCACTGTTTCAGTGCAATCTGTGCAAGAAACCGTTACCCTCCGCCCAAAAGCTCCAAGAACATCTGATCGATCATACGTTCGCGGGCTGTGAGGAGCGCGGCTACGTCTGCTACCTGTGCTCGGCCGTGTTTACCTCCTCGGCCGGACTGCAGACCCATCTGCCGCTGGCACATTCTAACGCGGCCGCCAAACCGTACGACTGTGAACGGTGCGGTGTGGCGTACTTTTTCCGGGCCGAGCTGGAGCACCATCTGATCGATCATGAGCTGGGCAAGGCGATGAGACCTTCCTCCTTTGAGCTAGCTTCGTCCGATGAGTGGCACACAATGGTGCAGCAGCGTTCTCCGATGGGTGAGGATGATGGTGGTGGCCACACAGGCCACATCAAGCAGGAACAGTGTGAGCCTGAGCAGGAACAGGATGGATCATCATCACCGTATCACCACCAGAAAGATGAAGATTCTGATGATGGGAACGACTTCCAACAGTCTAGAAACGGAGAGGAAACGAATGAGGTGGAAATGGAGCAGGAACAGGAGGACGAGGACAATGAACAGACTCACGCTGAGGAACGACAGGAAGAGCAGGAAGAGGATGAAGAGTACATTGAGGTAGAGCACACTACGCTGGATGATGGTGGACGAGGAGGCAAAGCAAGCGACGAACGGCTCCGTCGACCATCGAACCTGTTGATCAATGGCGGGAAGGATTGCTCTGCGCTGACTGCTACCACGACGGCAACCACTCTTCCGGTTGTAACGGCTGCTGAGTGA
Protein Sequence: MPFKCEYCARLFKHKRSRDRHTKLHTGDRRYRCLHCEAAFSRSDHLKIHMKTHDNQKPFQCTICNRGYNTAAALTSHMQNHKKQLALTGSPNLTYSPRSTTSSLSSGGGSGGGGKRGSKFSSYSNDPLMLMSRGNSKLSSSLSKAASIRTPTPGSTAGGGGPATLGGVGSGAGGGTGTAHHQDLLSCPYCTRTDFGTLEQLGLHVQSMHGHGGAGALGLLAGDSSMSYFTPAGGRRAVTPDGSNVPLSLGGLSPYPPISCEFCTMKFPTVPLMFAHLKTAHLDRLAGSGGHQRSSPSNGTGSPVGSRPPSGFHPLDQLHFNKSLLGSAFPSFYGGGSSNSLAGMSGGSIKAERRLMADRDENGNEEEAGGRKRQRRGDDGEDVRGSMSKRDKQEREEDEAIEGDQEDDADDDNDAEGDDNEEGESEAHGANNRCEESVDYKEEAIDTKITPIKQERKEEPAEGEPSPSTSARSSPCGDSLELGSGRPGSHPSGRTSPAEQLTPTDLSQPKMKRLKLETPEEDPVTDGADRKRMMMTASAAPGRSQTTREQHKHRGPGATATAASRRDSEAKDSNFQHGSLMHSSSSGSNVQHSHSQMGAPTSAGSSSQQHHQPPGAYLCNQCNAALPDFESFRSHLKAHLEQSAASAAAAAAMRLSGEHVNSGSSGGSSSSLSLTTFLCQQCGVTLSCQAEYEQHTIGHFLVMAVEYRCQGSTGTAGPASCSGKSTFGKVEDLHKHLYEGHMQLLYKCTVCGETFESKVQVQVHFAVSHSVEVKLYRCSACAEAFRSERDFRQHIRNRHLTAGAVQCMFCRMVCSSELEMHFHLASHARKYKCPACPESFHVEFLLDRHIQTHHSQKETSSPNRGRESANGGHNLSTTSSCSTNSTPSTATAVPSTAQPTSTTTTVTGLDYLHLHGQMAAMAAAAAWPTLYQTAANKFYSSNPLQVDTLSQLKHPQQLLHGFYDTMLGKAQAQQQQQRGAFLPESSSGGKKNPFVAGHSPNASANATNALLGLGYGGASLTSGNSQQQRTSTLNGSSSGLYSPEEGPNGGSSVATSSSKLYSPIAMIQRYGDGVAGVAALHSTPGTVPPTVTGCSSRTESPTPSGQQLLLAAHSTLSSLPEHHPEQQQSSNRKTAQPQSAPKTSSGTITPQLIAPGSNSCYSCGICERSDFSTESEVQTHRKIVHNLKTGVSLRCAYCNGDFRSRNELENHMKVAHNTGGGKHKCLICDEIFPSPAVLAEHKLTHCKVGASGRCSHCSLPLPDAHTFKQHLPAHQQIGGSSSGTTGAGTTTTTNGSSNGGTSGAGNSSTGQGASTSAGANSSGTGTSSNSNADQDRFPQQCICCRQTLNSEFEISLHAKFHTKTAETNERTCALCLEPLPSQPESNTKICDPCLKRHNFPTKLLSMNFLKPTTSSLVPTPTHGGSSSAGVVVPHTHGTTIGNSVAVEGRPPLPPPPPTSSGSLQQDPQHPDVGREGSSSALFQCNLCKKPLPSAQKLQEHLIDHTFAGCEERGYVCYLCSAVFTSSAGLQTHLPLAHSNAAAKPYDCERCGVAYFFRAELEHHLIDHELGKAMRPSSFELASSDEWHTMVQQRSPMGEDDGGGHTGHIKQEQCEPEQEQDGSSSPYHHQKDEDSDDGNDFQQSRNGEETNEVEMEQEQEDEDNEQTHAEERQEEQEEDEEYIEVEHTTLDDGGRGGKASDERLRRPSNLLINGGKDCSALTATTTATTLPVVTAAE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00095829;
90% Identity: iTF_00107176; iTF_00095829; iTF_00093654; iTF_00101143;
80% Identity: -