Afar003316.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Anopheles farauti
Gene Symbol
-
Assembly
GCA_000473445.2
Location
KI915045.1:8220704-8224488[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.00095 0.056 13.5 6.4 1 23 234 256 234 256 0.98
2 14 6.1e-07 3.6e-05 23.5 0.4 1 23 284 306 284 306 0.98
3 14 3.7e-07 2.2e-05 24.2 0.8 1 23 312 334 312 334 0.98
4 14 8.3e-07 4.9e-05 23.1 3.5 1 23 340 362 340 362 0.98
5 14 0.0002 0.012 15.6 1.0 1 19 368 386 368 389 0.95
6 14 1.3e-05 0.00075 19.4 0.8 1 23 395 417 395 417 0.98
7 14 1.4e-07 8.4e-06 25.5 1.1 1 23 426 448 426 448 0.99
8 14 7.8e-07 4.6e-05 23.2 0.7 1 23 454 476 454 476 0.99
9 14 0.009 0.53 10.4 0.2 1 19 483 501 483 502 0.95
10 14 0.00019 0.011 15.7 1.1 1 23 605 627 605 627 0.98
11 14 1.1e-06 6.3e-05 22.8 1.0 1 23 685 707 685 707 0.97
12 14 6.1e-07 3.6e-05 23.5 1.1 1 23 713 735 713 735 0.99
13 14 6e-05 0.0035 17.3 4.9 1 23 743 765 743 765 0.98
14 14 9.9e-08 5.8e-06 26.0 0.7 1 23 771 793 771 793 0.98

Sequence Information

Coding Sequence
ATGGCAGAAGATTTATCGATCAATAAAAATAAGATCTTCACACAGCGGTACGGAAATAGTAACAACGATATTTGTCGGTTGTGTCTGAAGAATGAAGCCCACATGGAACCACTTTTTTATTCCAACCTTTTCCCTAACATTCTACTCACGAAGAAGATATACGACTGTACCTCCATTCAGATCATCTACGAACGCAACCTGCCGATGTTCGTGTGTAAACTTTGCGCCAACAAGTTGGACGAGTACGTCCGCTTTCGGGATCGGTGCATTGCGAACGACGAGTTCCTGCGCAACGCGTTGGCTGCCTTCGGTGCGAACGGAGGCAACTGTTCCGGTACGATAAAGACTGAACCGGAAGATACGCCACCGCCATCGCAGGTACCAGCCGGTGCGAAGTTCGCCCAATGTCTCGGTGTGACGCCGATGGAGCTGAACTGTGCGCTGGTGGCAGCGGCTGCCGCAGCTGTCGGCCATCAGGGTGCTGGGAAGCGAGAACCACCGGACGTGGATGATCGTCACGATGTGTACGGTCTCGAGTCGGGTGTCGTATCGCCTAGCCACACGAGCTGCGGCCGTCTGACGATCGACGACGAGCTGACGCACAAGCAGACGCTCGATAATCGGTACCGAAGTGCGGACGAGGACGAACTACCCACCGACGATGGGTACGACGAGCGTAATCCATCGGAACGTGAACCATACGTGTGCGATGTGTGCTCGAAGTCGTTTAAGATACGCCATCACCTGTTAGTACATCGTCATACGCACATGGAGCAGCACGAGGAGGCGCTACAGCTGAACGGTGGTGGAGCTGAGTTCGGAGGCACCGGAGCGGGCGGTAAGCAATCGTACAACTGTCCGAAGTGCACCAAAGTGTTCGTGAACCGGGGCAACCTGCTGAACCACCTGGAGACGCACACGAACGAGAAGAGCTACGCGTGCGACATCTGCACGAAAACGTTCAAGTACAACGTGCAGCTGCGGCTGCATATGCGCATCCACACGGGCGAGCGGCCGCACAAGTGCGAGATCTGCAATCGCGGGTTTTCGCAGCTGTCTAATCTGCGCTCCCACCGGAAGACGCACTCGAAAGTCAAACCGTACAAATGCCACTTGTGTCTGAAGAGCTTCACCGTGCTGGACAACCTCACCGCGCACAGTACAAAGTGTCTGAAGGACAAGTTCCGCTGCACGCTCTGCTCGAAATCGTTCGCCAAGGAGGGCAACCTGCTGTCGCACCTGCAGTCGCACAGCGACGGCATCGTGGAGAAGATGTTCAAGTGCGAGATGTGCCCGAAGAGCTTCAAGAACAAGGAGGACTGGAAGCGGCACGTGCGTGTGCACACGGGCGAAAAGCCGTACACGTGCGACATCTGCTCGAAAGGGTTCGCCCAGAAGGCGAACCTGCTGTCCCACCGGAAGACGCACCTGAAACCGAACGTCGTGTACAAATGCGAACGGTGCGCCCGTACCTTCCGTTCGCAGAAGGTGCTGGAGATGCACGTGCCGAAGTGTTCCGGTACGATGGGACCGAACGGGGAGCCCGGTATCCCTTCCGCTCCGGTCACCCCCGTATCGGAGTCGATACCGGATTCGCCCAGCCCCGGCACGGCCGTTACGCTCTCGACGGAGGCATCCTCGGCCGCGGCCTCGACCACCAGCACACCGACGCTCTCGGAGGCACTGTCCGATCTGCTGCGGTACGAGATAGCGCTGCGTGCGCCACTCGAACTTCAGCAGATGCTTTTGGGCCATATCGATCGGAAAAAGGCACACAATGGTGCGGGTGGGGGTAAGGCGACGGGGCGACGCTATCGTTGTGACGTGTGCTTCAAGGGCTACTCGCAGTATCCGTCGCTGATCAAGCACCGGAAGCTACACTTCAAGGTGCCACCGCTGGTGAAAGTGTTGGCGGCGAAAGGACACCGGCACGAGGACTTCGACGATGCGACCGACCGGAGGGAACGGTGTGGGGATGAACGGCCGGACGAGTCCGGCGGGGAGCACCGCCGAACGCCGGGCCCGCACGACCACGCCACGCACGAGCGCCCGTACAGCTGTGATATATGCGGTAAGAACTTTAAATACAATCGTAACCTGAAGGTGCACGCCAAGCTGCACGTAAGGGCGAACCGTTTCAAGTGTGACAAGTGTACCACCACCTTTGCACAGGCGGAAGATTTGCGGCAGCATCTGCGCACCCACCGGACCGCTGCCGGCAGGAGCTTCAGCTGCGAGTACTGCTCGAACCACTTCCGCTCGAACGAGGACCTGAAGCGTCACCGCCGCTCGCACACCGGCGAGCGGCCGTTCCGGTGTCCGCGCTGCCCGAAGGCGTTTACCCAGCAGTCGAACATGCGGGCCCACACGAGGATCCACGACCGGGGAGCGGTGCAAGCAACCGAACCGCCACCCTCATCCAGCCACTGA
Protein Sequence
MAEDLSINKNKIFTQRYGNSNNDICRLCLKNEAHMEPLFYSNLFPNILLTKKIYDCTSIQIIYERNLPMFVCKLCANKLDEYVRFRDRCIANDEFLRNALAAFGANGGNCSGTIKTEPEDTPPPSQVPAGAKFAQCLGVTPMELNCALVAAAAAAVGHQGAGKREPPDVDDRHDVYGLESGVVSPSHTSCGRLTIDDELTHKQTLDNRYRSADEDELPTDDGYDERNPSEREPYVCDVCSKSFKIRHHLLVHRHTHMEQHEEALQLNGGGAEFGGTGAGGKQSYNCPKCTKVFVNRGNLLNHLETHTNEKSYACDICTKTFKYNVQLRLHMRIHTGERPHKCEICNRGFSQLSNLRSHRKTHSKVKPYKCHLCLKSFTVLDNLTAHSTKCLKDKFRCTLCSKSFAKEGNLLSHLQSHSDGIVEKMFKCEMCPKSFKNKEDWKRHVRVHTGEKPYTCDICSKGFAQKANLLSHRKTHLKPNVVYKCERCARTFRSQKVLEMHVPKCSGTMGPNGEPGIPSAPVTPVSESIPDSPSPGTAVTLSTEASSAAASTTSTPTLSEALSDLLRYEIALRAPLELQQMLLGHIDRKKAHNGAGGGKATGRRYRCDVCFKGYSQYPSLIKHRKLHFKVPPLVKVLAAKGHRHEDFDDATDRRERCGDERPDESGGEHRRTPGPHDHATHERPYSCDICGKNFKYNRNLKVHAKLHVRANRFKCDKCTTTFAQAEDLRQHLRTHRTAAGRSFSCEYCSNHFRSNEDLKRHRRSHTGERPFRCPRCPKAFTQQSNMRAHTRIHDRGAVQATEPPPSSSH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00104071; iTF_00103810; iTF_00099144; iTF_00108537;
90% Identity
-
80% Identity
-