Basic Information

Gene Symbol
MBD2_1
Assembly
GCA_018903425.1
Location
JAEIGD010000001.1:3768778-3770675[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6e-24 2.6e-20 72.1 0.1 1 74 7 75 7 78 0.94
2 2 1.4e-05 0.058 13.3 0.0 17 76 80 148 76 149 0.86

Sequence Information

Coding Sequence
ATGAATCCTAGCATAACAATCGAACGTAAACGCGTCGACTGCAACGCACTACCAAAAGGTTGGCAGCGCGAGGAAGTGCATAGAAAGTCTGGCTGCAATTCGGGAGTTGATGTTTTCTACTACAGCCCCACAGGCAAACGAATTGAAAGCAAGCCGCAATTGGTACGTCAACTAAGCGCCGAGATGTTTGATATAAGTAATTTTGATTTTCAAACCGGCAAGATGCATCAAATCCAGCGCCAAATGCCCTCACCGTCCATATCACTTCGCAATCTACGCTCAGATGTCTCACTGGTGCCGCCTATACGACAGACTGCCTCCATATTTAAGCAGCCGGTGACTGTGGTGCGTAATCATGAACCGAACAAGGTGAAGCACGATGCCAAACACGGTGGCCAGGAGAAACCCAAACAGTTATTCTGGGAGAAACGATTGGAACGCTTGCGGGCTTGCCACGACAACGGCGAGGAGTTGGATGACATCACACTGCCAAAGACCATTCGAACTGTCGGTCCCAATGTCAACGAACAGACTGTGCTGCAATCTGTGGCTACGGCGCTGCATATGCTGAATGCCGGCGTGCACGGCCAGAGCTCCACAAAGGCTGAGCTTACCAAGAATGCCATGGCATTCATGAATCCAGAGCAGCCGCTAATGCATGCGGTTATTATATCCGAGGATGATATACGAAAGCAGGAAGATCGCGTTGGCGTGGCACGTCGAAAATTACAGGATGCCCTCAAGACTTGA
Protein Sequence
MNPSITIERKRVDCNALPKGWQREEVHRKSGCNSGVDVFYYSPTGKRIESKPQLVRQLSAEMFDISNFDFQTGKMHQIQRQMPSPSISLRNLRSDVSLVPPIRQTASIFKQPVTVVRNHEPNKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDDITLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2