Zind003102.1
Basic Information
- Insect
- Zaprionus indianus
- Gene Symbol
- MBD2
- Assembly
- GCA_018904595.1
- Location
- JAEIHA010000320.1:8477341-8479105[+]
Transcription Factor Domain
- TF Family
- MBD
- Domain
- MBD domain
- PFAM
- PF01429
- TF Group
- Unclassified Structure
- Description
- The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 7.4e-24 2.5e-20 71.8 0.0 1 74 7 75 7 78 0.94 2 2 2.2e-05 0.072 12.6 0.0 28 76 117 174 104 175 0.87
Sequence Information
- Coding Sequence
- ATGAATCCTAGCATTACAATCGAACGTAAACGCGTCGACTGCAACGCATTACCAAAAGGTTGGCAGCGCGAGGAAGTGCATAGAAAGTCTGGCTGCAATTCGGGAGTTGATGTTTTCTACTACAGCCCCACAGGCAAACGAATTGAAAGCAAGCCGCAATTGGTACGTCAACTAAGCGCCGAGATGTTTGATATAAGCAATTTTGATTTTCAAACCGGCAAAATGAATCAAATCCAGCGCCAAATGCCCTCACCGTCCATATCGCTGTATCGGTGCAATGCAGCGGGCACAATTATCAGCAGCCCCGTCTCTGGGGGTAATGCTGCCAATGCCCTCAAGCGAAATCGCAATCTACGCTCAGATGTCTCACTGGTGCCGCCTATACGACAGACCGCCTCCATATTTAAGCAGCCGGTGACGGTGGTGCGTAATCATGAACCCAACAAGGTGAAGCACGATGCCAAACACGGTGGCCAGGAGAAACCCAAGCAGTTATTCTGGGAGAAACGATTGGAACGCTTGCGAGCTTGCCACGACAATGGCGAGGAGTTGGATGACATCACACTGCCAAAGACCATAAGAACTGTCGGTCCCAATGTTAACGAACAGACTGTGCTGCAATCGGTGGCCACAGCGCTGCATATGCTGAATGCCGGCGTGCACGGCCAGAGCTCCACAAAGGCGGAGCTTACCAAGAATGCCATGGCATTCATGAATCCAGAGCAGCCCCTAATGCATGCGGTTATTATCTCCGAGGATGATATACGGAAGCAAGAAGATCGCGTTGGTGTGGCACGACGAAAATTACAGGATGCCCTCAAGACTTGA
- Protein Sequence
- MNPSITIERKRVDCNALPKGWQREEVHRKSGCNSGVDVFYYSPTGKRIESKPQLVRQLSAEMFDISNFDFQTGKMNQIQRQMPSPSISLYRCNAAGTIISSPVSGGNAANALKRNRNLRSDVSLVPPIRQTASIFKQPVTVVRNHEPNKVKHDAKHGGQEKPKQLFWEKRLERLRACHDNGEELDDITLPKTIRTVGPNVNEQTVLQSVATALHMLNAGVHGQSSTKAELTKNAMAFMNPEQPLMHAVIISEDDIRKQEDRVGVARRKLQDALKT
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00478717;
- 90% Identity
- iTF_01556825;
- 80% Identity
- iTF_01552448;