Basic Information

Insect: Xiphydria camelus
Gene Symbol: PAX6
Assembly: GCA_963678675.1
Location: OY783192.1:5595863-5616740[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.8e-73 3.2e-70 234.3 0.6 1 125 26 150 26 150 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.8e-73	3.2e-70	234.3	0.6	1	125	26	150	26	150	0.99

Sequence Information

Coding Sequence: ATGCACGGGGGTGGCGCGGGTATTGGTGGGGGTTCTATGGTCGGACAGAACTCAATATTTGGGTGCTCGGCTGCAGGACACAGCGGTGTTAACCAGCTAGGCGGCGTTTACGTCAACGGACGACCTTTGCCAGATTCCACCCGCCAGAAAATCGTCGAATTGGCTCACAGTGGCGCGAGGCCTTGCGACATCTCGCGCATTCTCCAAGTCAGCAATGGCTGCGTCTCCAAGATCCTGGGAAGATACTACGAGACCGGCTCGATAAAACCGCGAGCGATAGGCGGCAGCAAGCCGCGCGTGGCGACGACGCCCGTGGTGAACAAAATCGCCGATTACAAGCGGGAGTGCCCCTCGATCTTCGCCTGGGAGATCCGGGATCGACTGCTGCAGGAGGGCGTCTGCAACAACGACAACATACCCAGCGTGTCGTCGATCAACAGGGTGCTGAGGAATTTGGCTTCGCAGAAGGAGCAACAGGCGGCCGCGGTGCAAGCGCATCAGGGCGCGGAGAGCGTCTACGACAAACTGAGGATGTTCAACGGGCAGGCTGCGGGCTGGCCTCCCGCGTGGTACTCCGCGACACCCTCTCATCATCCGCTGGCTACCGGAATCCCGACGGCGGCCACCCCTGGCTCCGGTCAATCGCTTTTGCCGGGTGGCCAGCTCCACGGGCGAGACGACTCCCTGCTTAAGCGGTCCGATACCGGCTCGCTGCTGTCGCACCAACAGGAAACCACGTCGGACGGCAACTCGGAGCACAATTCCTCCGGCGACGAGGACTCGCAGGTGCGGCTCAGGCTGAAGAGGAAGCTCCAGCGCAACCGGACCTCCTTCTCCAACGAGCAGATCGATAGTCTCGAGAAAGAGTTCGAGCGGACGCATTATCCGGACGTGTTTGCGCGGGAGCGTCTCGCCGAGAAGATTGGATTGCCTGAGGCACGTATCCAGGTATGGTTCAGCAATCGCAGGGCGAAGTGGCGTCGGGAGGAGAAGCTGCGGAATCAAAGGAGAGCGGCCGTCGATCAGGTGGTCGGCGGCGCGACGGGCGGTGGCGGTAGCACGGTGGCACCCTCTGCCGCGACCCCCGCGACGCCCAGACTACCGCTCAACGCCGGTTTCAACGCCATGTACTCCTCGATACCGCAGCCAATAGCGACCATGCCCGACACTTACAGTTCAATGTCGGGCAGCCTGGGCGGGTCAATGGGTGGAAGCTGTCTTCAGCAACGGGCCGAGGGATACCCCGCGTACGTTTTCCACGAGCCGCTCCACTCGCTCACGCAGTCTTACTCCCACGCGCACACCACCGCCGCGCATTCGCAACCCCATCGCGGGATACCGACCTCCCACGGGGGAACCCCCACCACACCGGGGGGGCAGCCCGCGGGACCAGGCGGAGCCCCCTACCAACCCACGACCTCCACCGCAACCGGCGTGATATCGGCAGGAGTGTCGGTGCCGGTGCAGATTCCATCGCAGACCCCGGACTTGACGGGCAACTACTGGCCCAGGCTCCAGTGA
Protein Sequence: MHGGGAGIGGGSMVGQNSIFGCSAAGHSGVNQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVNKIADYKRECPSIFAWEIRDRLLQEGVCNNDNIPSVSSINRVLRNLASQKEQQAAAVQAHQGAESVYDKLRMFNGQAAGWPPAWYSATPSHHPLATGIPTAATPGSGQSLLPGGQLHGRDDSLLKRSDTGSLLSHQQETTSDGNSEHNSSGDEDSQVRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRNQRRAAVDQVVGGATGGGGSTVAPSAATPATPRLPLNAGFNAMYSSIPQPIATMPDTYSSMSGSLGGSMGGSCLQQRAEGYPAYVFHEPLHSLTQSYSHAHTTAAHSQPHRGIPTSHGGTPTTPGGQPAGPGGAPYQPTTSTATGVISAGVSVPVQIPSQTPDLTGNYWPRLQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00294418;
90% Identity: iTF_01537678; iTF_00226433; iTF_00225859; iTF_00218948; iTF_00227909; iTF_00226539; iTF_00227117; iTF_00229870; iTF_00219056; iTF_00233072; iTF_00216914; iTF_00218258; iTF_00229971; iTF_00233171; iTF_00227220; iTF_00223029; iTF_00225750; iTF_00227799; iTF_00217017; iTF_00225081; iTF_00218362; iTF_00217595; iTF_00225181; iTF_00217695; iTF_00223135; iTF_00221858; iTF_00214339; iTF_00214245; iTF_00232551; iTF_00684007; iTF_00232457; iTF_00221770; iTF_00230638; iTF_00684111; iTF_00230549; iTF_00733909; iTF_00231928; iTF_00231834; iTF_00733818; iTF_01057475; iTF_01056627; iTF_01057589; iTF_01056761; iTF_01055806; iTF_01055934; iTF_01380451; iTF_01380552; iTF_01381167; iTF_01381274; iTF_01394243; iTF_01394121; iTF_01390158; iTF_01390040; iTF_01473123; iTF_01474629; iTF_00254156; iTF_00252014; iTF_01473015; iTF_01474522; iTF_00254268; iTF_00251902; iTF_00215652; iTF_00216228; iTF_00228612; iTF_00216330; iTF_00223819; iTF_00224397; iTF_00224497; iTF_00219639; iTF_00215546; iTF_00228506; iTF_00219743; iTF_00223712; iTF_00254918; iTF_00252652; iTF_00255025; iTF_00252761; iTF_01473864; iTF_00292219; iTF_01473756; iTF_00292126; iTF_00979913; iTF_00980068; iTF_01087050; iTF_01087145; iTF_00309453; iTF_00309353; iTF_00770318; iTF_00770210; iTF_01199982; iTF_00939362; iTF_00939491; iTF_01303299; iTF_00718373; iTF_01414119; iTF_00174123; iTF_00718507; iTF_00938635; iTF_01412268; iTF_01303149; iTF_00938512; iTF_01414000; iTF_00175697; iTF_00174866; iTF_00175602; iTF_01412149; iTF_00174008; iTF_00174971; iTF_00719227; iTF_00719358; iTF_01200094; iTF_00159055; iTF_00158945; iTF_01497359; iTF_01497226; iTF_01255376; iTF_01255495; iTF_01266832; iTF_01266730; iTF_01270341; iTF_01269633; iTF_01268109; iTF_01269743; iTF_01267506; iTF_01270450; iTF_01271157; iTF_01268217; iTF_01267386; iTF_01271035; iTF_00140529; iTF_00140425; iTF_00264849; iTF_00264944; iTF_00294418; iTF_00294305; iTF_00868724; iTF_00279805; iTF_00868606; iTF_00279903; iTF_00721205; iTF_00721089; iTF_01364469; iTF_01364590; iTF_00059286; iTF_00059403; iTF_00756470; iTF_00756582; iTF_00963030; iTF_01122275; iTF_01123012; iTF_00860969; iTF_01122378; iTF_01122922; iTF_00738288; iTF_00963796; iTF_00861082; iTF_00865851; iTF_00963708; iTF_00965980; iTF_00963134; iTF_00738175; iTF_00865951; iTF_00965888; iTF_01512134; iTF_01512035; iTF_01089832; iTF_01513997; iTF_01514670; iTF_01514099; iTF_01514771; iTF_01089942; iTF_01232946; iTF_01232848; iTF_01513311; iTF_01513417; iTF_00304919; iTF_00305007; iTF_01379159; iTF_01379047; iTF_01475287; iTF_01475393; iTF_00629048; iTF_00628942; iTF_00058522; iTF_00058646; iTF_00773754; iTF_00773636; iTF_00798522; iTF_00798437; iTF_00905370; iTF_00905256; iTF_00200699; iTF_00200591; iTF_00253403; iTF_00253509; iTF_00879579; iTF_00879462; iTF_00633468; iTF_00633574; iTF_00769468; iTF_00769569; iTF_00996988; iTF_00996865; iTF_00131901; iTF_00131799; iTF_01120061; iTF_01120154; iTF_01306397; iTF_01306300; iTF_00141182; iTF_00141137; iTF_01492830; iTF_01492718; iTF_01112418; iTF_01113254; iTF_01110056; iTF_01111595; iTF_01110765; iTF_01110898; iTF_01109941; iTF_01113365; iTF_01112535; iTF_01111710; iTF_01077311; iTF_00181250; iTF_01228226; iTF_01520066; iTF_00181156; iTF_00898692; iTF_00898597; iTF_00730570; iTF_00729132; iTF_00867340; iTF_01520174; iTF_00730678; iTF_00015320; iTF_00729241; iTF_00015227; iTF_00867232; iTF_01077408; iTF_01228320; iTF_01476866; iTF_01476769; iTF_00014564; iTF_00014666; iTF_00015887; iTF_00015985; iTF_01408136; iTF_01408004; iTF_01477513; iTF_01477413; iTF_01523305; iTF_01523205; iTF_01355255; iTF_01355148; iTF_01405528; iTF_01405635; iTF_01476121; iTF_01476024; iTF_00760832; iTF_00760932; iTF_01406336; iTF_01406441;
80% Identity: iTF_01537678;