Basic Information

Insect: Stenichneumon culpator
Gene Symbol: PAX6
Assembly: GCA_964017025.1
Location: OZ024777.1:14819586-14850423[-]

Transcription Factor Domain

TF Family: PAX
Domain: PAX domain
PFAM: PF00292
TF Group: Helix-turn-helix
Description: The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 2.2e-73 4.6e-70 233.8 0.5 1 125 44 168 44 168 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	2.2e-73	4.6e-70	233.8	0.5	1	125	44	168	44	168	0.99

Sequence Information

Coding Sequence: ATGGAGGAGCGTGGAAGAGAGACTGTAGAAAAGGCGGAAGGGAAGGAGGACTTGATGCACGGGGGCGGTCCGGGCATCGGCGGGGGTTCCATGGTCGGGCAGAACTCAATATTTGGCTGCTCGGCTGCGGGACACAGCGGCGTTAATCAGCTCGGTGGTGTTTACGTAAACGGACGACCACTTCCCGACGCGACGAGGCAAAAGATCGTCGAATTGGCGCACAGCGGCGCGAGACCGTGCGACATATCGCGCATTCTTCAGGTCAGCAACGGGTGCGTCTCCAAGATACTCGGGAGATATTACGAGACTGGATCGATAAAGCCAAGAGCGATCGGCGGAAGCAAGCCGCGCGTCGCGACGACCCCGGTTGTGAACAAGATCGCCGACTACAAGCGGGAATGTCCCTCGATCTTCGCCTGGGAGATTCGCGACCGGCTGCTTCAGGAAGGTGTCTGCAACAACGACAACATCCCGAGCGTCTCGTCGATAAACAGGGTGCTGAGGAATCTGGCCTCTCAGAAGGAGCAACAGGCGGCGGCGGTCCAGGCGCATCAGGGGGCCGAGAGTGTCTACGACAAACTGAGAATGTTCAACGGGCAGGCGACCGGTTGGCCTCCGGCGTGGTACTCGGCCACCCCGTCCCATCATCCCCTGGCCAGCGGAATACCGTCGGCCGGGACTCCCGGCTCCGGACAGTCCCTGCTACCCGGCGGACAGCTTCACGGACGCGACGATTCTCTGCTTAAACGATCCGACGCCGGATCTCTGCTCTCCCACCAACAGGAGACAACGTCCGATGGCAATTCCGAGCATAATTCCTCGGGAGACGAGGACTCGCAAGTTCGACTCAGGCTCAAGAGAAAGCTCCAGCGCAATCGCACGTCGTTCTCGAATGAACAGATCGAAAGTCTTGAAAAAGAATTCGAGCGGACCCACTACCCGGACGTTTTTGCCCGCGAACGTCTCGCCGAGAAGATTGGATTGCCTGAGGCACGTATCCAGGTGTGGTTCAGCAATCGCAGAGCAAAGTGGCGCAGGGAAGAGAAGCTGCGGAATCAGAGGAGGGCCGCCGTGGACCAGGTGGTCGGGGGTGCAACCGGCGGGGGCGGAAGTGGCGCGGCGCCACCGGCGGCGACCCCCGCTACGCCGAGGATACCGCTCAACGCCGGTTTCAACGCCATGTACTCATCGATACCGCAACCGATCGCCACGATGCCCGACACTTACAGTTCGATGTCAGGCAGCCTCGGCGGCTCGATGGGTGGTAGCTGCCTTCAACAACGAGCCGAGGGCTATCCGGCGTACGTTTTTCACGAGCCACTTCACTCGCTAACGCAATCCTACTCCCACGCTCATACAACGGCGGCTCACTCGCAACCCCATCGCGGTATACCGACCTCTCACGGCGGTACACCCACCACACCGGGGGGACAGCCCGCTGGTCCAGGCGGGGCGCCCTATCAACCGACGACGTCGACCGCTACCGGAGTGATATCGGCAGGAGTATCGGTACCAGTTCAGATACCGTCGCAGAGTCAGGATCTCACCGGCAACTATTGGCCCCGGCTTCACTGA
Protein Sequence: MEERGRETVEKAEGKEDLMHGGGPGIGGGSMVGQNSIFGCSAAGHSGVNQLGGVYVNGRPLPDATRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVNKIADYKRECPSIFAWEIRDRLLQEGVCNNDNIPSVSSINRVLRNLASQKEQQAAAVQAHQGAESVYDKLRMFNGQATGWPPAWYSATPSHHPLASGIPSAGTPGSGQSLLPGGQLHGRDDSLLKRSDAGSLLSHQQETTSDGNSEHNSSGDEDSQVRLRLKRKLQRNRTSFSNEQIESLEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRNQRRAAVDQVVGGATGGGGSGAAPPAATPATPRIPLNAGFNAMYSSIPQPIATMPDTYSSMSGSLGGSMGGSCLQQRAEGYPAYVFHEPLHSLTQSYSHAHTTAAHSQPHRGIPTSHGGTPTTPGGQPAGPGGAPYQPTTSTATGVISAGVSVPVQIPSQSQDLTGNYWPRLH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00317416;
90% Identity: iTF_01537888;
80% Identity: iTF_01364469;