Pden022687.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Pseudomyrmex dendroicus
Gene Symbol
pax6
Assembly
GCA_014825645.1
Location
QVNZ01008868.1:52907-74358[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.2e-73 3.4e-70 234.3 0.6 1 125 34 158 34 158 0.99

Sequence Information

Coding Sequence
ATGCCGCATAAAGAAGAGGACTTGATGCACGGGGGTGGCGCGGGTATTGGCGGGGGTTCTATGGTCGGACAGAACTCAATATTTGGGTGCTCGGCTGCAGGACACAGCGGGGTTAACCAGCTTGGCGGTGTTTACGTCAATGGCCGACCGCTGCCGGACTCCACAAGGCAGAAGATCGTCGAGCTGGCCCATAGCGGGGCCAGACCGTGCGACATATCGCGTATACTGCAGGTCAGCAATGGATGCGTCTCCAAGATCCTTGGCAGGTATTACGAGACTGGCTCGATCAAGCCGCGGGCGATCGGTGGTAGCAAGCCACGGGTGGCGACAACACCTGTGGTCAACAAAATCGCCGACTACAAACGAGAATGTCCCTCGATCTTCGCCTGGGAGATTCGCGATCGACTTTTGCAGGAGGGCGTTTGCAATAACGACAATATACCCAGCGTGTCATCTATCAACAGGGTACTCAGGAACTTGGCCTCGCAAAAGGAGCAACAGGCGGCCGCGGTGCAAGCGCATCAGGGCGCCGAGAGTGTCTACGATAAGCTGAGAATGTTCAACGGGCAGGCAGCAGGTTGGCCGCCTGCGTGGTACTCGGCAACACCTTCTCATCATCCCTTAGCTACGGGAATTCCAACGGCGGCAACTCCTGGATCCGGCCAAACTCTTCTGCCCGGCAGTCAGCTGCATGGACGCGACGATTCTCTACTGAAGCGAAGTGATACTGGTTCTCTATTATCGCATCAGCAGGAGACAACTTCGGACGGTAATTCGGAACACAACTCCTCTGGCGACGAGGACTCGCAGGTGCGGTTGAGGCTGAAGAGGAAATTGCAACGCAACCGAACTTCCTTCTCTAATGAACAGATAGACAGCCTCGAGAAAGAATTCGAGCGGACACATTACCCGGACGTGTTTGCACGGGAGCGTCTCGCCGAGAAGATCGGATTACCTGAGGCACGTATCCAGGTGTGGTTCAGTAATCGTAGGGCAAAGTGGCGTCGAGAGGAGAAATTACGGAACCAGAGGAGGGCTGCCGTCGATCAGGTGGTCGCCGGCGGCAACGGCGGGGGTAGCAGCGGCGCTGCGCCTTCCGCGGCCACCCCCGCTACACCACGGTTGCCCTTAAACGCCGGATTCAACGCCATGTATTCGTCGATACCACAACCAATCGCCACCATGCCCGACACGTACAGCTCCATGTCAAGCAGCCTGGGCGGCTCAATGGGCGGAAGCTGTCTTCAACAACGTGCCGAAGGCTATCCGGCATACGTGTTCCATGAGCCTCTTCATTCGCTCACGCAGTCTTACTCTCACGCACACAGCGCGGCCGCAGCCGCGCACTCGCAACCCCATCGCGGTATCCCAACGTCTCACGGTGGTACTCCCACAACGCCGGGAGGACAACCCGGACCAGGTGGAGCACCCTACCAGCCAACGACCTCGACCGCGACCGGAGTGATATCGGCGGGCGTCTCGGTGCCGGTGCAGATTCCCTCGCAGACCCCGGATCTGGCGGGTAACTATTGGCCGAGGCTCCAGTGA
Protein Sequence
MPHKEEDLMHGGGAGIGGGSMVGQNSIFGCSAAGHSGVNQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVNKIADYKRECPSIFAWEIRDRLLQEGVCNNDNIPSVSSINRVLRNLASQKEQQAAAVQAHQGAESVYDKLRMFNGQAAGWPPAWYSATPSHHPLATGIPTAATPGSGQTLLPGSQLHGRDDSLLKRSDTGSLLSHQQETTSDGNSEHNSSGDEDSQVRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRNQRRAAVDQVVAGGNGGGSSGAAPSAATPATPRLPLNAGFNAMYSSIPQPIATMPDTYSSMSSSLGGSMGGSCLQQRAEGYPAYVFHEPLHSLTQSYSHAHSAAAAAHSQPHRGIPTSHGGTPTTPGGQPGPGGAPYQPTTSTATGVISAGVSVPVQIPSQTPDLAGNYWPRLQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01268109; iTF_00226433; iTF_00225859; iTF_00218948; iTF_00227909; iTF_00226539; iTF_00227117; iTF_00229870; iTF_00219056; iTF_00233072; iTF_00216914; iTF_00218258; iTF_00229971; iTF_00233171; iTF_00227220; iTF_00223029; iTF_00225750; iTF_00227799; iTF_00217017; iTF_00225081; iTF_00218362; iTF_00217595; iTF_00225181; iTF_00217695; iTF_00223135; iTF_01269633; iTF_01269743; iTF_01271157; iTF_01271035; iTF_00221858; iTF_00214339; iTF_00214245; iTF_00232551; iTF_00684007; iTF_00232457; iTF_00221770; iTF_00230638; iTF_00684111; iTF_00230549; iTF_00733909; iTF_00231928; iTF_00231834; iTF_00733818; iTF_01112418; iTF_01113254; iTF_01110056; iTF_01111595; iTF_01110765; iTF_01110898; iTF_01109941; iTF_01113365; iTF_01112535; iTF_01111710; iTF_01476866; iTF_01476769; iTF_01122275; iTF_01123012; iTF_01122378; iTF_01122922; iTF_00963796; iTF_00963708; iTF_01380451; iTF_01380552; iTF_01381167; iTF_01381274; iTF_00014564; iTF_00014666; iTF_00015887; iTF_00015985; iTF_00085124; iTF_00087106; iTF_01001090; iTF_00088771; iTF_00085318; iTF_01002027; iTF_00088621; iTF_01000495; iTF_00086224; iTF_00084369; iTF_00084497; iTF_00086004; iTF_01001207; iTF_01000377; iTF_01001916; iTF_00086941; iTF_00996168; iTF_00996289; iTF_00451766; iTF_00451883; iTF_01560383; iTF_01560274; iTF_00215652; iTF_00216228; iTF_00228612; iTF_00216330; iTF_00223819; iTF_00224397; iTF_00224497; iTF_00219639; iTF_00215546; iTF_00228506; iTF_00219743; iTF_00223712; iTF_01067492; iTF_01067556; iTF_01306300; iTF_01306397; iTF_01232260; iTF_01232354; iTF_00898597; iTF_00898692; iTF_00879462; iTF_00200591; iTF_00200699; iTF_00879579; iTF_01394243; iTF_01394121; iTF_01390158; iTF_01390040; iTF_00979913; iTF_00980068; iTF_01408902; iTF_01512134; iTF_01512035; iTF_01089832; iTF_01513997; iTF_01514670; iTF_01514099; iTF_01514771; iTF_01089942; iTF_01408136; iTF_01408004; iTF_01477513; iTF_01477413; iTF_01523305; iTF_01523205; iTF_00730570; iTF_00729132; iTF_00867340; iTF_00730678; iTF_00729241; iTF_00867232; iTF_01087050; iTF_01087145; iTF_00143819; iTF_00143719; iTF_01036964; iTF_00286279; iTF_01035370; iTF_01036044; iTF_01035279; iTF_01036151; iTF_00286168; iTF_01036863; iTF_00159055; iTF_00158945; iTF_00738288; iTF_00738175; iTF_01255376; iTF_01255495; iTF_01266832; iTF_01266730; iTF_00140529; iTF_00140425; iTF_00264849; iTF_00264944; iTF_00645810; iTF_00645901; iTF_01232946; iTF_01232848; iTF_01270450; iTF_01270341; iTF_00708404; iTF_00708488; iTF_00714324; iTF_00714217; iTF_01190164; iTF_01190283; iTF_00756470; iTF_00756582; iTF_01355255; iTF_01355148; iTF_01405528; iTF_01405635; iTF_00087769; iTF_00087947; iTF_01476121; iTF_01476024; iTF_00773754; iTF_00773636; iTF_00861082; iTF_00860969; iTF_01267386; iTF_01267506; iTF_01539547; iTF_01539445; iTF_00769468; iTF_00769569; iTF_00996988; iTF_00996865; iTF_01120061; iTF_01120154; iTF_00253509; iTF_00254918; iTF_00252652; iTF_00255025; iTF_00252761; iTF_00253403; iTF_00141182; iTF_00141137; iTF_00302974; iTF_00302876; iTF_00868606; iTF_00868724; iTF_00963134; iTF_00963030; iTF_00279903; iTF_00279805; iTF_01099135; iTF_01099033; iTF_01513311; iTF_01513417; iTF_00760832; iTF_00760932; iTF_00965888; iTF_00965980; iTF_01077408; iTF_01077311; iTF_01406336; iTF_01406441;
90% Identity
iTF_01537888;
80% Identity
iTF_01268109;