Basic Information

Gene Symbol
lolal
Assembly
GCA_951394055.1
Location
OX596019.1:7502804-7503763[-]

Transcription Factor Domain

TF Family
BTB
Domain
zf-C2H2|ZBTB
PFAM
PF00651
TF Group
Zinc-Coordinating Group
Description
The BTB (for BR-C, ttk and bab) [6] or POZ (for Pox virus and Zinc finger) [1] domain is present near the N-terminus of a fraction of zinc finger (Pfam:PF00096) proteins and in proteins that contain the Pfam:PF01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerisation and in some instances heteromeric dimerisation [1]. The structure of the dimerised PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule [2]. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT [5, 3, 4]. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.4e-32 1.3e-29 103.8 0.1 1 104 21 120 21 125 0.93

Sequence Information

Coding Sequence
ATGGCCGATCAACAATTCTTTTTAAAATGGAATGATTTCCAAACGAATATGGTTACATCTTTTAGACATTTAAGAGATGAAAAAAGTTTTACAGATgtaACATTAGCTTGTGAAGGTCAAACATGTAAAGCGCATAAAATGGTATTATCGGCATGCAGTCCATATTTTAAATCATTGCTAGAGgaAAATCCATCAAAACAtccaattattatattaaaagatGTCTCATATATTCATCTTCAGGCAATATTAGAATTTATGTATGCGGGTGAGGTGAATGTATCACAAGAACAATTACCAGCATTCCTTAAAACTGCTGATAGATTAAAAGTGAAAGGTTTAGCTGAAACACCGACTAATCAAATCAAAAGGGATGGTTGA
Protein Sequence
MADQQFFLKWNDFQTNMVTSFRHLRDEKSFTDVTLACEGQTCKAHKMVLSACSPYFKSLLEENPSKHPIIILKDVSYIHLQAILEFMYAGEVNVSQEQLPAFLKTADRLKVKGLAETPTNQIKRDG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00139785;
90% Identity
iTF_01140289; iTF_00249793; iTF_00321697; iTF_00784513; iTF_00834753; iTF_01124705; iTF_01152289; iTF_01359873; iTF_01507329; iTF_00035842; iTF_00425570; iTF_01021410; iTF_01192834; iTF_01416002; iTF_01436226; iTF_01451618; iTF_01502210; iTF_01506466; iTF_01546754; iTF_00409411; iTF_00428259; iTF_00432355; iTF_00809283; iTF_00815875; iTF_00933955; iTF_01080003; iTF_01317411; iTF_01332931; iTF_01532227; iTF_00122532; iTF_00149540; iTF_00274532; iTF_00467492; iTF_01008612; iTF_01130116; iTF_01133892; iTF_01134916; iTF_01316484; iTF_00013189; iTF_00180581; iTF_00301317; iTF_00341445; iTF_00772133; iTF_00822085; iTF_00839525; iTF_00888389; iTF_01217605; iTF_01337829; iTF_01425221; iTF_01494405; iTF_01535045; iTF_00115046; iTF_00120646; iTF_00354278; iTF_00406854; iTF_00666630; iTF_00761798; iTF_00781926; iTF_00811142; iTF_01027462; iTF_01084390; iTF_01509702; iTF_00008135; iTF_00043687; iTF_00121575; iTF_00173191; iTF_00751271; iTF_00779591; iTF_00795815; iTF_00802023; iTF_00833191; iTF_01041927; iTF_01281447; iTF_01335111; iTF_01361767; iTF_01490247; iTF_00022920; iTF_00040008; iTF_00075656; iTF_00123496; iTF_00407688; iTF_00468264; iTF_00660424; iTF_00711112; iTF_00776104; iTF_00823144; iTF_00923816; iTF_00948008; iTF_01010504; iTF_01017832; iTF_01029384; iTF_01141768; iTF_01202568; iTF_01285672; iTF_01439144; iTF_00027881; iTF_00156361; iTF_00430761; iTF_00450281; iTF_00642473; iTF_00685577; iTF_00908041; iTF_00973897; iTF_01061993; iTF_01085513; iTF_01183017; iTF_01302505; iTF_01339049; iTF_01360809; iTF_00072202; iTF_00164490; iTF_00300362; iTF_00648234; iTF_00790410; iTF_01147466; iTF_01176266; iTF_00375435; iTF_00449291; iTF_00683467; iTF_01020427; iTF_01031243; iTF_01203339; iTF_01377611; iTF_01437195; iTF_01538891; iTF_00023884; iTF_00205292; iTF_00345932; iTF_00353260; iTF_00383820; iTF_00447372; iTF_00681740; iTF_00712044; iTF_00724044; iTF_00736716; iTF_01076652; iTF_01205004; iTF_01440204; iTF_01526188; iTF_00282541; iTF_00441645; iTF_00621325; iTF_00657325; iTF_00667661; iTF_00787789; iTF_00799373; iTF_01064781; iTF_01081709; iTF_01125581; iTF_01197901; iTF_01205805; iTF_01260237; iTF_00433262; iTF_00445326; iTF_00462510; iTF_00820206; iTF_00909806; iTF_00952814; iTF_01026446; iTF_01220750; iTF_01251950; iTF_01463406; iTF_00017455; iTF_00146543; iTF_00157327; iTF_00433263; iTF_00457327; iTF_00622095; iTF_00726575; iTF_00836687; iTF_00887503; iTF_01086383; iTF_00177296; iTF_00208016; iTF_00342320; iTF_00365040; iTF_00458160; iTF_00677776; iTF_00778832; iTF_00791312; iTF_00850896; iTF_00951952; iTF_00986352; iTF_01083472; iTF_01135888; iTF_01148912; iTF_01204176; iTF_01444016; iTF_01508176; iTF_00114193; iTF_00124401; iTF_00302257; iTF_00758385; iTF_00782737; iTF_00810225; iTF_00906289; iTF_01028433; iTF_01082577; iTF_01206673; iTF_01221713; iTF_01452465; iTF_00037938; iTF_00155410; iTF_00412626; iTF_00723250; iTF_00970514; iTF_00994450; iTF_01115794; iTF_01151314; iTF_01562098; iTF_00034899; iTF_00036947; iTF_00682547; iTF_00774579; iTF_00869779; iTF_00907155; iTF_01073715; iTF_01173395; iTF_01340339; iTF_01544051; iTF_00010260; iTF_00021428; iTF_00038964; iTF_00235956; iTF_00247316; iTF_00276564; iTF_00323604; iTF_00656244; iTF_00695796; iTF_00806836; iTF_00889364; iTF_00954676; iTF_01071732; iTF_01141012; iTF_01464276; iTF_01503092; iTF_00144757; iTF_00355317; iTF_00408565; iTF_00780341; iTF_00828053; iTF_00934933; iTF_00958037; iTF_01248309; iTF_01534069; iTF_01569461; iTF_00041014; iTF_00185430; iTF_00186390; iTF_00208982; iTF_00284662; iTF_00357750; iTF_00358742; iTF_00752182; iTF_00776790; iTF_01016854; iTF_01030358; iTF_01178742; iTF_01180406; iTF_01222582; iTF_01334006; iTF_00119703; iTF_00148567; iTF_00237879; iTF_00256055; iTF_00744855; iTF_01090903; iTF_01166839; iTF_01280503; iTF_01495127; iTF_00042776; iTF_00171960; iTF_00195256; iTF_00257048; iTF_00279224; iTF_00281496; iTF_00356408; iTF_00680696; iTF_00786104; iTF_00831352; iTF_00928824; iTF_01079160; iTF_01094168; iTF_01143192; iTF_01495864; iTF_00009177; iTF_00112601; iTF_00248217; iTF_00325529; iTF_00772985; iTF_00819289; iTF_00835705; iTF_00859609; iTF_01181977; iTF_01564793; iTF_00000442; iTF_00651866; iTF_00707098; iTF_00745914; iTF_00896986; iTF_01018682; iTF_01153114; iTF_01246042; iTF_01544986; iTF_00012123; iTF_00041915; iTF_00288155; iTF_00410427; iTF_00658523; iTF_00663195; iTF_00775355; iTF_00953659; iTF_01063867; iTF_01144635; iTF_01401403; iTF_01416955; iTF_01453371; iTF_01543067; iTF_00150748; iTF_00158140; iTF_00411580; iTF_00843644; iTF_00897916; iTF_01080828; iTF_01149692; iTF_01368220; iTF_00026973; iTF_00364157; iTF_00429149; iTF_00674397; iTF_00878941; iTF_01279389; iTF_01312317; iTF_01363229; iTF_01430045; iTF_01438141; iTF_01545853; iTF_00074654; iTF_00178334; iTF_00236734; iTF_00794782; iTF_00858686; iTF_00871422; iTF_01193694; iTF_01230750; iTF_01527454; iTF_00071615; iTF_00273727; iTF_00290815; iTF_00403935; iTF_00448255; iTF_00781119; iTF_00783647; iTF_01062943; iTF_01093247; iTF_01503999; iTF_00007232; iTF_00382784; iTF_00673600; iTF_00785312; iTF_00824864; iTF_00851936; iTF_00924896; iTF_01095072; iTF_01179584; iTF_01358976; iTF_01441216; iTF_01492128; iTF_01561216; iTF_00855974; iTF_01487818; iTF_00778093; iTF_00095714; iTF_00104454; iTF_00107056; iTF_00099729; iTF_00093523; iTF_00101749; iTF_00108469; iTF_00097851; iTF_00102430; iTF_00103074; iTF_00100379; iTF_00099069; iTF_00106461; iTF_01456131; iTF_01454954; iTF_01457483; iTF_00456236; iTF_00746790; iTF_00337601; iTF_00471681; iTF_00485921; iTF_00574113; iTF_00592449; iTF_00802913; iTF_01358081; iTF_00303874; iTF_00503330; iTF_00512066; iTF_00543810; iTF_00583746; iTF_00584482; iTF_00604162; iTF_00605634; iTF_00616258; iTF_01200962; iTF_01549634; iTF_00359523; iTF_00498211; iTF_00551651; iTF_00797827; iTF_00805251; iTF_00922179; iTF_01175203; iTF_01313891; iTF_01550339; iTF_00203652; iTF_00257924; iTF_00331588; iTF_00518500; iTF_00527364; iTF_00533156; iTF_00548868; iTF_00891044; iTF_00972292; iTF_01256484; iTF_01471588; iTF_00427333; iTF_00472421; iTF_00483045; iTF_00515653; iTF_00539717; iTF_00550309; iTF_00562533; iTF_00563237; iTF_00563973; iTF_00575653; iTF_01325733; iTF_01552517; iTF_01562981; iTF_00191430; iTF_00335974; iTF_00427334; iTF_00495174; iTF_00525190; iTF_00542502; iTF_00589606; iTF_00599654; iTF_00957190; iTF_01177030; iTF_00092231; iTF_00514951; iTF_00531015; iTF_00537575; iTF_00555911; iTF_00566855; iTF_00580039; iTF_00616967; iTF_00619207; iTF_00904807; iTF_00310344; iTF_00473128; iTF_00528872; iTF_00566152; iTF_00593896; iTF_00653608; iTF_00892840; iTF_00918216; iTF_01321256; iTF_01364008; iTF_00045417; iTF_00118793; iTF_00424745; iTF_00478793; iTF_00480233; iTF_00492297; iTF_00531721; iTF_00550953; iTF_00573385; iTF_00628457; iTF_00748297; iTF_01314761; iTF_00193642; iTF_00455018; iTF_00501866; iTF_00516330; iTF_00523018; iTF_00553098; iTF_00612138; iTF_00615626; iTF_00919882; iTF_01055306; iTF_01183914; iTF_01321994; iTF_00324523; iTF_00338411; iTF_00509163; iTF_00511339; iTF_00521419; iTF_00546027; iTF_00558731; iTF_00564715; iTF_00604907; iTF_00612875; iTF_00618475; iTF_00749035; iTF_01165611; iTF_01174347; iTF_01375019; iTF_00091404; iTF_00133356; iTF_00533868; iTF_00578604; iTF_00587468; iTF_00614252; iTF_00749772; iTF_00804460; iTF_00812876; iTF_00817516; iTF_00832236; iTF_01326476; iTF_01396620; iTF_01554028; iTF_00350253; iTF_00483757; iTF_00497453; iTF_00504749; iTF_00508397; iTF_00549613; iTF_00588909; iTF_00591757; iTF_00595309; iTF_00596717; iTF_00601869; iTF_00603405; iTF_00643309; iTF_00914573; iTF_01350829; iTF_00061198; iTF_00475278; iTF_00519982; iTF_00554446; iTF_00561102; iTF_00593166; iTF_00598222; iTF_00948878; iTF_01288270; iTF_01541518; iTF_01563854; iTF_00234063; iTF_00494447; iTF_00544559; iTF_00555151; iTF_00579343; iTF_00582319; iTF_00583023; iTF_00586031; iTF_00588207; iTF_00609231; iTF_00750543; iTF_00916303; iTF_00975695; iTF_01019503; iTF_01195343; iTF_01224687; iTF_01559823; iTF_00190032; iTF_00202704; iTF_00363344; iTF_00523760; iTF_00535376; iTF_00539024; iTF_00541136; iTF_00557264; iTF_00569040; iTF_00617712; iTF_00937392; iTF_01324976; iTF_01553296; iTF_00092881; iTF_00476689; iTF_00477393; iTF_00488081; iTF_00540433; iTF_00567601; iTF_00569745; iTF_00803665; iTF_00806033; iTF_01045553; iTF_01189585; iTF_01554769; iTF_00062866; iTF_00336818; iTF_00473842; iTF_00528114; iTF_00585266; iTF_00594610; iTF_00606386; iTF_00891954; iTF_01551794; iTF_00400691; iTF_00500371; iTF_00510611; iTF_00512787; iTF_00534643; iTF_00538291; iTF_00552371; iTF_00597427; iTF_01320531; iTF_01555475; iTF_00160820; iTF_00484500; iTF_00493716; iTF_00504052; iTF_00513524; iTF_00526644; iTF_00611412; iTF_00816628; iTF_00915412; iTF_00921492; iTF_01319828; iTF_00491573; iTF_00495925; iTF_00501109; iTF_00553781; iTF_00571221; iTF_00586741; iTF_00919125; iTF_01023093; iTF_01313077; iTF_01327957; iTF_01486293; iTF_00190742; iTF_00371158; iTF_00479542; iTF_00485206; iTF_00488726; iTF_00577846; iTF_00607126; iTF_00614966; iTF_00967286; iTF_00999734; iTF_01194486; iTF_00176503; iTF_00192887; iTF_00251415; iTF_00313559; iTF_00493015; iTF_00507671; iTF_00529623; iTF_00532439; iTF_00579351; iTF_00094552; iTF_00097144; iTF_00470936; iTF_00475992; iTF_00496664; iTF_00505464; iTF_00506936; iTF_00509880; iTF_00520696; iTF_00571960; iTF_00572664; iTF_00591032; iTF_01196056; iTF_01542296; iTF_01548920; iTF_01557624; iTF_00435641; iTF_00498937; iTF_00530329; iTF_00543161; iTF_00579353; iTF_00644217; iTF_00979417; iTF_01162329; iTF_01315577; iTF_01558361; iTF_00199962; iTF_00480922; iTF_00489434; iTF_00490842; iTF_00517050; iTF_00570458; iTF_00576410; iTF_01297594; iTF_01524954; iTF_00367291; iTF_00482299; iTF_00499643; iTF_00519227; iTF_00522235; iTF_00608507; iTF_00760187; iTF_01404987; iTF_01556187; iTF_00098460; iTF_00401820; iTF_00502588; iTF_00560348; iTF_00601116; iTF_00609948; iTF_00619900; iTF_00747548; iTF_01109404; iTF_01404988; iTF_01540444; iTF_00258973; iTF_00311133; iTF_00478077; iTF_00545309; iTF_00547421; iTF_00557981; iTF_00568317; iTF_00600381; iTF_00610717; iTF_00624829; iTF_01011325; iTF_01323453; iTF_00235006; iTF_00339230; iTF_00490142; iTF_00581598; iTF_00595998; iTF_00598942; iTF_00793598; iTF_00901566; iTF_01212062; iTF_01322718; iTF_00062015; iTF_00453663; iTF_00474559; iTF_00486623; iTF_00487359; iTF_00561823; iTF_00577119; iTF_00580799; iTF_01319103; iTF_01327231; iTF_01378463; iTF_01470591; iTF_01556895; iTF_01559103; iTF_00192160; iTF_00481600; iTF_00506176; iTF_00536832; iTF_00541824; iTF_00546720; iTF_00548128; iTF_00559552; iTF_00565440; iTF_00574880; iTF_00602656; iTF_00917280; iTF_01132992; iTF_01261088; iTF_01324192; iTF_01154215; iTF_00662337; iTF_01387713; iTF_00635522; iTF_01219874; iTF_01388610; iTF_01208387; iTF_01429155; iTF_00033924; iTF_00686468; iTF_01336036; iTF_00275429; iTF_00703045; iTF_01528421; iTF_00163078; iTF_01159526; iTF_01264806; iTF_01161480; iTF_01209416; iTF_00044617; iTF_00072937; iTF_00161673; iTF_00827113; iTF_00844489; iTF_01170697; iTF_01403563; iTF_00318188; iTF_00050061; iTF_00632877; iTF_00704110; iTF_00705134; iTF_00926734; iTF_01501262; iTF_00361743; iTF_00896047; iTF_01171567; iTF_00634609; iTF_01386833; iTF_00702098; iTF_00706130; iTF_00213651; iTF_00696563; iTF_00698419; iTF_01078323; iTF_00267316; iTF_00649236; iTF_01341428; iTF_00250581; iTF_00856757; iTF_01172501; iTF_00207094; iTF_00212662; iTF_00147639; iTF_00737591; iTF_00390521; iTF_00825914; iTF_00913722; iTF_00377211; iTF_00701179; iTF_00942939; iTF_01385915; iTF_00661436; iTF_01336988; iTF_00204445; iTF_00700221; iTF_00925853; iTF_00033022; iTF_01529310; iTF_00055551; iTF_00063711; iTF_00638751; iTF_00206208; iTF_00818432; iTF_00935840; iTF_00384648; iTF_01115086; iTF_01114328; iTF_01114329; iTF_00796620; iTF_00348269; iTF_00020593; iTF_00130634; iTF_00965279; iTF_01012498; iTF_00675215; iTF_00299216; iTF_00347574; iTF_01117466; iTF_00419841; iTF_01119490; iTF_00111779; iTF_00960260; iTF_00715878; iTF_00461675; iTF_00959500; iTF_01118445; iTF_01034703; iTF_01033840; iTF_00421459; iTF_00420635; iTF_00697468; iTF_00842780; iTF_00958748; iTF_00419070; iTF_00997819; iTF_01168514; iTF_00210886; iTF_00246408; iTF_00451117; iTF_01265915; iTF_01383003; iTF_01382172; iTF_00211709; iTF_00245503; iTF_00345152; iTF_01136987; iTF_01510853; iTF_01530361; iTF_01164061; iTF_00402846; iTF_00514239; iTF_01570300;
80% Identity
-