Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 6.1e-23 4.4e-19 68.6 0.0 1 65 57 123 57 123 0.94

2 3 0.72 5.2e+03 -2.1 0.0 11 29 129 146 128 148 0.74

3 3 6.7e-17 4.8e-13 49.3 0.1 1 64 158 248 158 249 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	6.1e-23	4.4e-19	68.6	0.0	1	65	57	123	57	123	0.94
2	3	0.72	5.2e+03	-2.1	0.0	11	29	129	146	128	148	0.74
3	3	6.7e-17	4.8e-13	49.3	0.1	1	64	158	248	158	249	0.89

Coding Sequence: ATGTATGAAGATGACAACATATCTTGTACTCCCAAACGCTGTGTGCTCACTGAGGTGACCAACTCATCCACTTATGTGTCGCCCAATGCTAACCTCAAGTTGCTTACCAATGTCGCCCTGCAGTACCCAACTCCGCCGTCAAGCGCCGGCGCCGCTGCCGTCCAGCGTAAAGAAAAGTCTCTACAAATACTTTGTGATAGATTCCTCAAGCTTTATCCATTGCATGGAAATGGAACAGTCGAAATACAACTGGACACCACTGCAGCCAGCCTTGGAGTGGAAAAGCGACGAATGTATGATATCGTCAACATACTAGAAGCTATGCAGTGTGCAGTTCATAAGAGAAAAAACACATATCTTTGGCATGGAGGGTCTCGTTTAAATGGTTTTCTCAAGCTGCTGAAAAAACAAGGGGAGAACTTGAAGCTATCTGAAGTACTAAGAGGAAGAGCACCAAAACCTCCACCACCAAAGCACAAGACTCTAGGGGTGTTGGCTCAAAGATTTCTTATGTTATTTTTGGTGGAACCTCATAATACTCTTATAAATTTGGAAATGGCTGTAAGGGTGCTAATTGACACATCTAATAAGAATAAGACAGTCTTGTCTCCGGAGCAACAAGAACGCCAGCACAAGTCTAAAGTTAGGAGGCTTTATGACATAgccaatgtatttatttctattggtCTCATAGAAAAGGTTTCTGGTAATTTAATATTGAAGAAACCTGTATTTAAGTATGTAGGGCCATTCAAATCCAAAAAGTCTGATAAGGTGATCGGCACTCCTTCACCGATCACACCACTTGCTGTGTTAGACAGTCAGCAGAGGGGCAATGTGCTTGCAGGGAAATCCAAACGGAAACTGGAGTTTACCACTCCAAGCACTTCCCGGGATCTAAAGCTTGGTATCACCACACCACCAAACACCCCATCTCACAAATGGGATGAGATTTTGCTTGTTGCAGATATGGAACTGACTAGGATTAACAATGGTGTTAAATTGTGA
Protein Sequence: MYEDDNISCTPKRCVLTEVTNSSTYVSPNANLKLLTNVALQYPTPPSSAGAAAVQRKEKSLQILCDRFLKLYPLHGNGTVEIQLDTTAASLGVEKRRMYDIVNILEAMQCAVHKRKNTYLWHGGSRLNGFLKLLKKQGENLKLSEVLRGRAPKPPPPKHKTLGVLAQRFLMLFLVEPHNTLINLEMAVRVLIDTSNKNKTVLSPEQQERQHKSKVRRLYDIANVFISIGLIEKVSGNLILKKPVFKYVGPFKSKKSDKVIGTPSPITPLAVLDSQQRGNVLAGKSKRKLEFTTPSTSRDLKLGITTPPNTPSHKWDEILLVADMELTRINNGVKL

Sequence clustering based on sequence similarity using MMseqs2