Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_943736035.1
Location
CALSEY010000217.1:144171-155450[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 4.7e-17 5.6e-13 49.7 0.2 6 69 280 343 275 351 0.91
2 2 2.3 2.7e+04 -3.8 0.0 41 64 920 942 917 945 0.76

Sequence Information

Coding Sequence
ATGGTAAGCCGCGGAGGCCTCAAGTTTTTCCCTGGTGCAAAGTTGGAAGCTAAGGATTTCAATGAAAAATGGTATACAGCACGTGTAGTTGAGACCGACTGGGTCGAAAGAGAAGTGTTGATACACTTTGACAAATGGAGTTCAAGATTCGATGAATGGATACCAATGGACAGCTCAAGGCTACGAGTACTTCAAGTACAGCCAAACGAGTCAACTTGGACGCTACCACCTCCGGAGACGAAAATGCGTGAATTTGTGGCTGGTGAAAGAATTCTAGCTACTTGGGCTGACGGTAGGAAATATCCTGCCAAAGTAAAGACTGTGTTGGGAAATGACAGATACGACGTTCTGTTCGACGATGGTTATGCGAAAATAGTCAGATCGTCAAAGATGACCAAAATTGCTGCCACTACCGAAAAGAAACCAATAGATGGGGATTACATAGGTAGTAAACAAGAGAGAAGAGATAAGAAAAGAAAGCATAGTGTTATGGATCTGTTTCAATCTAACGCCAAGAAACGGCCTAGAACAGATTCAGAAAAATCGTTAAAAAAAGAAGAGTCGTTGATAAGCGAAGACGATAATCAAGTCGAAAAACCCGAATTGATGACACCAGCGATAGCTTACGAATCTGGCACAGAGGTACTCAAAGGGTTCGAACCGAGTAAACCAAAGGTTAAAACTTATGCTAAGAAAAAGAAGAAGGAAATATCTATATCTAATAAGATTGATACAGATAACGAAGACGAGATAGTGCCAGAATGGATTGACGGCGAACCACAAGGAATAGAGTCTTATATTGTCGATGGTAATGACGGACCACGTCGGTCTATCATTGTTGCGGATAAGAGATTACCGCCTGGGTGGCAGAAGCACTTTACTCAGAGAAGAACTGGCACCTCTGCCGGAAAGTGGGATGTTTTGTTTATACACAAATCAAGTGGTAAAAAGTTTAGATCGCGTAACGATATTCGAGCGTTTATGGAACTTCAAGGGCAGTTTGATTTCGAACCAGAGAAATTTGACTTCTGTATACATCGTAAGAAGAACAGCAAATCTAACGCTGCTAAATTGAAGCAGGAACAACCACCGATAGAAGTTCCAAAAAAAATCAAAACTCTTTTGCCCAAAACAAAAACACCCGTCAGCACTCCTGACCCTATACCTCTATGCGTTGTACCACCGCCTGTTCAACCACCACCAATTACTCCGGTTACACCTGCAGATCCTGGTGCTGTTTTCATCGGAGGACTCCGTGTTGAGATGGAAGACAGTGCTTATAAATGTCCAAAAGAAGGTTGCAACAAAAATTTTCGTAAAGAAAATCTTCTTCAAATGCATATCAAGCATTATCACCCAGAGTATTCAAAATTTTTGGGATCAACACCGAACGTAGCAGACTTAGCTTACGCTAGAACGATTGGGGAGTCAATCGAAGACATAATACCGAAGAAACAGAACAATTTTTTAGAAAAAATCAACAAATTTGAGAAGAAGAAGGCATCCCAAGAGAAACATGTGTCTGTTAATGAATCAGAAACGAATAGAACCGAAAAAATATCCACCGCAATAAAAGAGGATTCAAAATTTGAAATAACTTCACCTATTTCAAACCAAGGCATCGAATTGGACGACGATATTATTAAAAAGAGGGAAGCTAGCTGCGCAATGTCGCCTGGTACTTTGTTCGACCTGAAAATCAGGGAAGAAAAAACTCAAACAGGAATTAAAACTTTATTACCGGTGGTTAGACCAGCACTTCCCAATCCACTCACAATCAACGTAGCTGCTGAATTAAGCAAATTGGATAGGTCAAAATCGTTGGACGAACCATCGGTATCGGAAAAGGGAAAGTCCATAAGGAAACGACAAATGTCGGAATATAATTCTGATCAAGTACAAATAAAGTACAAGAAAAAACAAGAGCTTAAGGAAGATTACGGGGATTTAGATGATGGTACTTTGGACATTGAGGAGCCGGTTGCCCCTACGTACCGATTCAGTCGTAGAAAATCCGATCCAAAGAGCGATGAGAATAGTCAAACCAGTCAACTAAACGATTCTCATCTTGATAAAGGTGATACCCCTAAAGGGGATGCTGCCAAAAGAGATAATAGTAATGATAATACTGAAGATGGAGACGGGGTAATGATGATGATTAATGGGGAAATGATCAAGGTGGAGCAACTTCGTAGAGAAGAAATAATAAATTGTACTTGCGGATTCATGGAAGAAGATGGATTAATGATACAATGTGATCTTTGCCTTTGCTGGCAGCACGGACACTGCAATGCTATTGAAAGGGAAAAAGATGTGCCAGAAAAATATGTATGCTACATTTGTCTCAATCCTTATAGACAAAGATCGTCTAAGAAATATATTCACGATCAGGATTGGATTAAAGAAGGAAAATTGCCGAGTCTGTCTAATCGTACCAAGAATCAATCTGCGATCGATCAAAGGACTGCGATGTTGAAACGGTCGTACGACTTAGTTGCCGCATTGCTACAAATACAACAAATTCTTCATAGTCTAAGAGTGAAAATCAATGTCGCGGAAAAAAAGGATCATCCGAAATTATATCTTTGGGCAAAAAATTGGGAGAAATCCGAGATACCAACGCCGGATACCGATCCAGTGCCAATAATGGAAATTGTTAAACCACCTTTAGAAACAGCAGAGTCTAGTTTGGACAGTTCACCCACTACTGAAATAAAAGTTGAAATAAAGGAAGAACCGAAGGAGGAACCTGACGAGAAATCAATCGCATCGAATTCAGAACTGATGAAAATTTTAGAAGAAGATAGTCTGCATGCCGAAGAACTTAAGAATATTAAAAAACAGGAGAGCCAAAACGAAGGACATATTCTTTTGGAAGCATTGACCAGAAATAGTACAGACAAAATAGCTTCGGAATTGAAAACTGATAACAGCGAGCCACCAAATAATCAGCCATCTACGTCCAAGACGCCAGATCTGATCTCTTCAAATCCAACTGAGAATGAACACCAAGAGGCTCGTTTGAGTGAAATTTTACCACTACAACCTTTCATACCGGAACCAGAGGCTCCGATAGACCCTGCTGAGTGTCGTTCGAGACTTTTGGACCACATTGATCATTTTCAAAATCATATAGATTCGCGGCTTATTACCATCGAGGCACAAGTGTCTGCACTAGAGGCCATGGATCCAGATGATACTGTATCTAATCCTGATATTTTGCCTCGAACAAAGCAGACCGTACAAATGCTACTAAGGGATTTAGCGACTGTTAGAAAACTCGCCGCTCTTTGCTGA
Protein Sequence
MVSRGGLKFFPGAKLEAKDFNEKWYTARVVETDWVEREVLIHFDKWSSRFDEWIPMDSSRLRVLQVQPNESTWTLPPPETKMREFVAGERILATWADGRKYPAKVKTVLGNDRYDVLFDDGYAKIVRSSKMTKIAATTEKKPIDGDYIGSKQERRDKKRKHSVMDLFQSNAKKRPRTDSEKSLKKEESLISEDDNQVEKPELMTPAIAYESGTEVLKGFEPSKPKVKTYAKKKKKEISISNKIDTDNEDEIVPEWIDGEPQGIESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRRTGTSAGKWDVLFIHKSSGKKFRSRNDIRAFMELQGQFDFEPEKFDFCIHRKKNSKSNAAKLKQEQPPIEVPKKIKTLLPKTKTPVSTPDPIPLCVVPPPVQPPPITPVTPADPGAVFIGGLRVEMEDSAYKCPKEGCNKNFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESIEDIIPKKQNNFLEKINKFEKKKASQEKHVSVNESETNRTEKISTAIKEDSKFEITSPISNQGIELDDDIIKKREASCAMSPGTLFDLKIREEKTQTGIKTLLPVVRPALPNPLTINVAAELSKLDRSKSLDEPSVSEKGKSIRKRQMSEYNSDQVQIKYKKKQELKEDYGDLDDGTLDIEEPVAPTYRFSRRKSDPKSDENSQTSQLNDSHLDKGDTPKGDAAKRDNSNDNTEDGDGVMMMINGEMIKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYVCYICLNPYRQRSSKKYIHDQDWIKEGKLPSLSNRTKNQSAIDQRTAMLKRSYDLVAALLQIQQILHSLRVKINVAEKKDHPKLYLWAKNWEKSEIPTPDTDPVPIMEIVKPPLETAESSLDSSPTTEIKVEIKEEPKEEPDEKSIASNSELMKILEEDSLHAEELKNIKKQESQNEGHILLEALTRNSTDKIASELKTDNSEPPNNQPSTSKTPDLISSNPTENEHQEARLSEILPLQPFIPEPEAPIDPAECRSRLLDHIDHFQNHIDSRLITIEAQVSALEAMDPDDTVSNPDILPRTKQTVQMLLRDLATVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01200150;
90% Identity
iTF_00938692;
80% Identity
-