Cins009485.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Chelonus insularis
Gene Symbol
pax6
Assembly
GCA_013357705.1
Location
NW:82854-114609[-]

Transcription Factor Domain

TF Family
PAX
Domain
PAX domain
PFAM
PF00292
TF Group
Helix-turn-helix
Description
The paired domain, a ~126 amino acid DNA-binding domain, is found in eukaryotic transcription regulatory proteins involved in embryogenesis. Initially identified in Drosophila’s paired (prd) protein, it typically resides in the N-terminal region and may be followed by an octapeptide, a homeodomain, or a Pro-Ser-Thr-rich C terminus. Paired domain proteins act as transcription repressors or activators, with DNA-binding specificity mediated by three subdomains. Crystal structures reveal a bipartite DNA-binding paired domain: an N-terminal subdomain (PAI) and a C-terminal subdomain (RED), linked by a flexible linker. Both subdomains contain a helix-turn-helix motif that binds DNA's major groove, while the linker may bind the minor groove. Variations in domain usage across Pax proteins and isoforms determine sequence specificity.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.4e-73 1.6e-70 234.0 0.6 1 125 100 224 100 224 0.99

Sequence Information

Coding Sequence
ATGCAGTGTGTTAGCGTGGCCGGAGGCGGCGGGGGTGTCTCGGGTGCCGGAAGTGACGGCGTCTCAGATTACCCGCCGAGCGCTGCGGCTGTTCGGAGCAGAGAAGCGGCCGCGGCGGCACTGCACGCGGCAAGAACGTTGTTGGGCGCGGGGGTGGCTAACCCTTGCTCGTCCACCCCCGAGCCATCCTTCTGGAAGATGCCACACAAAGAGGAGGATTTGATGCACGGGGGCGGTCCGGGTATTGGCGGGGGTTCTATGGTCGGTCAGAACTCAATATTTGGGTGCTCGGCTGCAGGACACAGTGGGGTCAACCAGCTTGGTGGCGTTTACGTTAATGGCCGACCATTGCCGGACTCGACGAGGCAAAAGATCGTGGAATTGGCACATAGCGGTGCGAGACCGTGTGACATTTCGCGCATACTCCAAGTCAGCAATGGATGTGTCTCCAAAATCCTTGGGAGATATTATGAAACTGGATCGATAAAACCTCGAGCGATTGGCGGCAGTAAACCACGCGTTGCAACAACTCCGgtggtaaataaaattgctgaCTACAAGCGTGAATGTCCATCAATTTTCGCCTGGGAAATTCGTGATCGGTTGCTTCAGGAAGGCGTTTGCAACAATGACAATATTCCTAGTGTGTCCTCCATCAACAGGGTGCTTAGAAACTTGGCCTCGCAGAAAGAGCAACAGGCAGCGGCTGTACAGGCGCATCAGGGTGCTGAAAGTGTCTACGATAAGTTGAGGATGTTTAATGGGCAAGCAACAGGATGGCCACCAGCATGGTATTCAGCAACACCATCACATCATCCTCTAGCTACAGGAATACCTACAACTGTTACACCTGGAACTGGTCAGTCTCTCTTACCTGGTGGTCAACTTCATGGTCGTGATGATTCTCTGCTCAAACGATCTGATGCTGGATCATTGTTGTCACATCAACAAGAAACAACGTCAGATGGTAATTCTGAACACAATTCCTCTGGAGATGAAGACTCTCAGGTGCGGCTGAGGTTGAAGCGCAAACTCCAACGTAATCGCACGTCATTCTCAAACGAGCAGATCGACGCTCTCGAGAAAGAATTCGAGCGGACACATTATCCGGACGTGTTTGCGCGGGAGCGTCTCGCCGAGAAGATTGGATTGCCTGAGGCACGTATCCAGGTTTGGTTCAGTAATCGCAGGGCAAAATGGcgaagagaagaaaaattacgTAATCAACGAAGAGCTGCTGTTGATCAAGTTGTTGGTGGTGCTGCTACTGGAGGGGCAGGAAGTGGTGTTGCTCCACCTGCAGCTACACCTGCAACACCTCGGATACCTCTAAATGCTGGTTTTAATGCCATGTATTCCTCAATACCACAACCAATTGCCACTATGCCTGATACTTATGgCTCAATGACTAGTAGTTTGGGTGGATCAATGGGAAGTAGTTGTCTTCAACAACGAGCTGAAGGGTATCCAGCATATGTATTTCACGAACCTCTGCACTCGTTGACGCAATCTTATTCTCATGCTCACACAACTGCAGCACATTCGCAACCCCATCGTGGCATACCGACCTCCCATGGTGGAACACCGAGCACACCAGGGGGTCAACCAGGAGCTCCAGGAGGGACACCATACCAACCCACGACTTCTACTGCGACTGgaGTGATATCAGCAGGAGTATCAGTACCAGTTCAGATTCCATCTCAAACTCCAGACCTAACAAGTAACTATTGGCCACGGCTTCAGTGA
Protein Sequence
MQCVSVAGGGGGVSGAGSDGVSDYPPSAAAVRSREAAAAALHAARTLLGAGVANPCSSTPEPSFWKMPHKEEDLMHGGGPGIGGGSMVGQNSIFGCSAAGHSGVNQLGGVYVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVNKIADYKRECPSIFAWEIRDRLLQEGVCNNDNIPSVSSINRVLRNLASQKEQQAAAVQAHQGAESVYDKLRMFNGQATGWPPAWYSATPSHHPLATGIPTTVTPGTGQSLLPGGQLHGRDDSLLKRSDAGSLLSHQQETTSDGNSEHNSSGDEDSQVRLRLKRKLQRNRTSFSNEQIDALEKEFERTHYPDVFARERLAEKIGLPEARIQVWFSNRRAKWRREEKLRNQRRAAVDQVVGGAATGGAGSGVAPPAATPATPRIPLNAGFNAMYSSIPQPIATMPDTYGSMTSSLGGSMGSSCLQQRAEGYPAYVFHEPLHSLTQSYSHAHTTAAHSQPHRGIPTSHGGTPSTPGGQPGAPGGTPYQPTTSTATGVISAGVSVPVQIPSQTPDLTSNYWPRLQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00316609; iTF_00317308; iTF_00316733; iTF_00828616; iTF_00262497; iTF_00829443; iTF_00263397; iTF_00439302; iTF_00263239; iTF_00829323; iTF_00262606; iTF_01298995; iTF_01299123; iTF_00828726; iTF_00439417; iTF_00350841; iTF_00350953; iTF_00168219; iTF_00168369; iTF_01057475; iTF_01056627; iTF_01057589; iTF_01056761; iTF_01055806; iTF_01055934; iTF_00265514; iTF_00265635; iTF_00309453; iTF_00309353; iTF_00377965; iTF_00377831; iTF_00046916; iTF_00438026; iTF_00438698; iTF_00046795; iTF_00046093; iTF_00045972; iTF_00728505; iTF_00728605; iTF_00437918; iTF_00438590; iTF_01004182; iTF_00047907; iTF_01003369; iTF_00378699; iTF_01003476; iTF_01006008; iTF_01004060; iTF_00378557; iTF_01005854; iTF_00047807; iTF_01497359; iTF_01497226; iTF_00754418; iTF_00754575; iTF_01207186; iTF_01207302; iTF_00266293; iTF_00266401; iTF_00343125; iTF_00343050; iTF_00721205; iTF_00721089; iTF_01364469; iTF_01364590; iTF_00059286; iTF_00059403; iTF_01379159; iTF_01379047; iTF_00058522; iTF_00058646; iTF_00305594; iTF_00305495; iTF_00798522; iTF_00798437; iTF_00131901; iTF_00131799; iTF_00459582; iTF_00459698; iTF_00937856; iTF_00937967;
90% Identity
iTF_00316609; iTF_00317308; iTF_00316733; iTF_01001090; iTF_01002027; iTF_01000495; iTF_01001207; iTF_01000377; iTF_01001916; iTF_00829443; iTF_00439302; iTF_00829323; iTF_00439417; iTF_00046916; iTF_00047907; iTF_01207302; iTF_00438026; iTF_00438698; iTF_00046795; iTF_00046093; iTF_01207186; iTF_00045972; iTF_00728505; iTF_00728605; iTF_00437918; iTF_00438590; iTF_00047807; iTF_01067556; iTF_01067492; iTF_01232260; iTF_01232354; iTF_00350841; iTF_00350953; iTF_00168219; iTF_00168369; iTF_00996168; iTF_00996289; iTF_00734410; iTF_00326212; iTF_00326327; iTF_00734520; iTF_00714324; iTF_00714217; iTF_01099135; iTF_01099033; iTF_01190164; iTF_01190283; iTF_00451766; iTF_00451883; iTF_00828726; iTF_00828616; iTF_00840890; iTF_00398024; iTF_00397900; iTF_00397238; iTF_00397114; iTF_00841018; iTF_01560383; iTF_01560274; iTF_00937856; iTF_00937967;
80% Identity
iTF_00317308;