Basic Information

Transcription Factor Domain

TF Family: zf-GAGA
Domain: zf-GAGA domain
PFAM: PF09237
TF Group: Zinc-Coordinating Group
Description: Members of this family bind to a 5'-GAGAG-3' DNA consensus binding site, and contain a Cys2-His2 zinc finger core as well as an N-terminal extension containing two highly basic regions. The zinc finger core binds in the DNA major groove and recognises the first three GAG bases of the consensus in a manner similar to that seen in other classical zinc finger-DNA complexes. The second basic region forms a helix that interacts in the major groove recognising the last G of the consensus, while the first basic region wraps around the DNA in the minor groove and recognises the A in the fourth position of the consensus sequence [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 8 4.4 3.5e+03 -1.7 0.0 26 48 88 110 73 115 0.75

2 8 0.00062 0.49 10.6 0.9 24 48 115 139 95 142 0.85

3 8 0.0007 0.55 10.5 0.3 18 48 138 168 136 173 0.88

4 8 6.5 5.2e+03 -2.2 0.0 23 44 172 193 168 198 0.79

5 8 0.0023 1.8 8.8 0.4 21 49 199 227 196 232 0.86

6 8 0.099 78 3.6 0.2 23 48 230 255 227 257 0.88

7 8 7.7e-07 0.00061 19.9 1.7 17 49 253 285 251 289 0.86

8 8 0.0018 1.5 9.1 0.3 17 48 282 313 281 315 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	8	4.4	3.5e+03	-1.7	0.0	26	48	88	110	73	115	0.75
2	8	0.00062	0.49	10.6	0.9	24	48	115	139	95	142	0.85
3	8	0.0007	0.55	10.5	0.3	18	48	138	168	136	173	0.88
4	8	6.5	5.2e+03	-2.2	0.0	23	44	172	193	168	198	0.79
5	8	0.0023	1.8	8.8	0.4	21	49	199	227	196	232	0.86
6	8	0.099	78	3.6	0.2	23	48	230	255	227	257	0.88
7	8	7.7e-07	0.00061	19.9	1.7	17	49	253	285	251	289	0.86
8	8	0.0018	1.5	9.1	0.3	17	48	282	313	281	315	0.90

Coding Sequence: ATGGACAATTGGATGGACCCTTTTCAGTGTAATTCAGACTCAGAAAGATTCACTCGTGCCTTGTTTATGAATCACTCTGGTGGTAGCGTTTGGGAACAGCCTTCTACATCATTTCCAGAAAATTCATATAACTATGATTATGGCTACCAAAATGGTGGACAGTATGGAGCTCCTTATAATGGAGAAGGAAATAATATGGGAAACGGACATGTTTACCCTAATTCTCACGGGCAGCCTTCTATGGAATCGCCTATGGGCTACAACTGTGATCAGTGTGATTTTGTCACGGACAAACCGAGTTCTTTAAAAAGCCACATAAAAACAAAACATGGAAATCAAAAAACTCTCCAGTGCCCTCACTGTGAATATGTTGCTGCACAGACAGCTCACCTGAAGCGGCACATAGCAGCTCGGCATAGCAGCGACAAACCGAATAAATGCCCTTACTGTTCGTACAGCTCCGTCCAGCCGGGATCACTAAGGACTCACCTCCTAGCTAAACACTCCGACCAGAAGCCGTACAAGTGTTTGCACTGTGACTTCACTACATCGGAATCGAATGAGCTGAAAGAGCACATCGCAGGCCTTCACGCTGATGAAAAACCTTACAAATGCCCACTGTGTGAGTATTGCGCTGCTGAGAACAGTGTACTCCGGAAGCACATCACCGCAAAGCATATCAAGCAGAAGCCATACCAGTGCCCCCACTGCGAGTACTGCACCGCGCTCTCGGGCAATCTCAAGGTCCACGTCATGTCTAAGCACACTAAGGAGAAGCCCCACCAATGCCCCCACTGCAAATATGCTGCCGTCCAATCTGCCAATCTCCGTCGGCATATTATATCTCGACATACTAAAGACAAACCATTTCAGTGTATACTCTGCAATTACAGTGCTTCCCAGTCTGTCGATTTGAGAAAACACATGCTGAGGAAACACAATTCTTAA
Protein Sequence: MDNWMDPFQCNSDSERFTRALFMNHSGGSVWEQPSTSFPENSYNYDYGYQNGGQYGAPYNGEGNNMGNGHVYPNSHGQPSMESPMGYNCDQCDFVTDKPSSLKSHIKTKHGNQKTLQCPHCEYVAAQTAHLKRHIAARHSSDKPNKCPYCSYSSVQPGSLRTHLLAKHSDQKPYKCLHCDFTTSESNELKEHIAGLHADEKPYKCPLCEYCAAENSVLRKHITAKHIKQKPYQCPHCEYCTALSGNLKVHVMSKHTKEKPHQCPHCKYAAVQSANLRRHIISRHTKDKPFQCILCNYSASQSVDLRKHMLRKHNS

Sequence clustering based on sequence similarity using MMseqs2