Basic Information

Gene Symbol
-
Assembly
GCA_036289425.1
Location
JAZAQC010000025.1:1979524-1989136[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 6.2e-15 3.9e-11 42.9 0.0 9 72 157 226 153 229 0.95
2 2 0.051 3.2e+02 1.5 0.0 22 70 351 395 345 401 0.71

Sequence Information

Coding Sequence
ATGGATAAATTGGAGAGAAAGAAATCTGCTggtttaaaagaaACCAATAATCTTTTAAACCTAGAAGCACATTTTGTTGGAtttgatattgatgatgaagtgttgataataattgaaaataagaaaaaatCATTAAAAATGGAACTTAGTAAAGAAACAGGTGAACCTATGGAAGTAGACGAGCCAACTGATAGTCCAtccattgttaataataatcattttaataaaaagaaacaatCTAAATTAAGTAtattgtcACCAGAACCTAATGATGCTAAAAATAATCGGAGTAATAAAAGGCATAAGAAAGACAACACACGTAGTGATACCTTAGAATCTTTGGAATTACATGCTCCACCCTCTTTAGaACTTACTACTCCCACATTCAACTTAACTTCTTCTAACACTAGAACGCGCCGTAGTACAGGcagaaaaattaatgttgataTCAGTGATGCTATTTTTAAACTCCCATTTGAGCAtggaTGGAAACGAGAATTAGTATATCGAACATCAGGTGAATCTACTGTTCTTAATCGGGCAAATAGAAGTGGtgatgtatactattattctCCAAATAACCGAAAACTACGATCATTACGAGAAATTCAAGAACAATTGGATATCTCATCTGATAAAACTTCTCTTACTATTGACAGTTTTACCTTTTTAAAACAACCAATTGGCATGAATGATAGATCAAAAGAACTGATCAGAGATGCAAATTCTAAATTATCTAaggaagACTCTTTTGTTGGTGTTGCTGTTCGacctaaaaaatctaaaacaccCGTACCACGCCCACCATTTGATTATGAATTGTCAGATGATGAAAACAAAAAGTCTGCtagtaaaatgaaaattgtttttaagaaTGCAAAGACTTCCTCAAGATCAAGATCCAAAaaagggAATTCAGAATTAATGAATACATCTTCATCCACACCTGAATACATATCTGAAGACTGGCAAGCTATTCAATCTAGTGTGTCACCAAAAGTTTCTCCTAAACTTGAGAACAAAGATACAAATAACATAATCATTAAAAGACGGTTGTCAGCATCAGATGGGGAAGTCATCATGCAGACTCCTTGTGGTATACGGTGCCCTAATAGTCATGAACCTGCAACTTTAATGTGTACTCAATGTCTGGTCTACTATCATCCAGCATGTGTCAGTTTAAatgctaatttaaaaattgttggtTATGTATGTTTAaaCTGTCGATGTATTATACGAAAAAGAAATCATCATGTAATGTTAGCTAATTCTGTGATTGTTGATGCTACTGAACTGGAGCAACAACTACGTGTTGAACCGATTCGTATAAGACAAGTTCATCAAGCATCAGATACACCTAATTTCTTTATTGATAGAACACCAATTTCTAAAATTGAAGAACCACATGAAATTGATGAATGTAGTGATGAAAGTgactctaataatataaatactgttaTATGTCAaggaaatgtatataaaactaCAATGGTTGATGGTAGTTTTCACGAACAGTATGTTTATGAAATGAAACAAACACGAGGACCTAGTTTGATGACTTGTGTTGTTCAAGAGCCCAAAAATTTGGAAGAGAATTCTGAAATGAACGGTTCATATAAAGAAATTGTAACTCCTTTCGCATCCATGCAGTCATTTAACTACATGGTTAAAGCATTGAGacacgtttttaaatatttaaaaacacatgAGCTTTTATCCGCTTCTAGAGTATGTACCGCCTGGCATATAATTGCAATGAACAAGTTCTTAtggCAAAATGttcgtttaaaaaattctatGGTCTATGACTGGGAAAGGTTTGTAGACTCTATTGATCAACAGAGAAGTGATACATTAGATACTAGACGAATGTTGATACCTGTCAAAGTTGATGAATTCGAAAATTTTTGGTTGCATTTTTCCAAAGCAATGAAAAGAGCACAGAAGTTAAAATTCATTGAATTGTATAGATGTCCTACCCATGTAGTTGAAGATATTATTTACTCATTACCTCAACTTGAAGTACTTAATGCAACttcaataaaaaatccaAATGTAACAAAAGAGGCTAAAAATGCCAATGATTTTATGaccttaaacttaaattatttaggtcAAATGACAAAGCTCACTGAGTTAAGACTAAAAGGTTTAACTGGAATCAAATTAACGTCATTGCcatcatttgaaaatttaataaatttaaataaattttcatTAACCTCCATAAAATCATTTCCAAAAGACATCTGTCAGAGTTTGGATACTATTACTGATAACTTAGAATTTTTGGAAATTGGTGATTGCGATTGCTTATCAAAAGATTTTGCTGTATCACTAAAAAGATTTGTTAATTTGAAATCTTTGAGATTGGAAAATTGTTGCGGTAAATGGGATAGTTGTGCTCAAGATGTTTTTACTGTTATTAGGGGTCTTGAAAAGCTTACTATTCTGGAATTGGTAAACATAGAATTCAGTAATTGTGTTGAAGATGAATTGGAAAAATGTGTTGGTATTAAAGCTTTACTGATTATTCCTGCTTATGTGAGCCAAtcaGCAACTACCAACTGCCACTTGATTGACTGCCTCAAGAAACTCTCCAAGACATTAACGCACTTGGTTTGGGGATTGACTCATGAACTGCTCCGTGTTACTGACTTATTTATAACTCAATATCAACAAAACCAGCATAGTATtggttataatttagaattatcCCATACCAAAGAAACGACCAATAACATACCTATACTAAGGACAAGAAAACCCAGACAACGGCCAGGAGATGAGCCTGCTCCTGAAAAGGACAAGGACAAAGACAAATCAGATAATGTTGATATACTTTCAGTTCCTGCTCTAGAGAAATTGTTAGATACAATGATGCCTGATGCTAAAACAAGGGTAATTAAGGTTCCTTTTTCGGGAACAGTTAGAGTTTATTTAAGTGAACAGTTTAATGATCtttga
Protein Sequence
MDKLERKKSAGLKETNNLLNLEAHFVGFDIDDEVLIIIENKKKSLKMELSKETGEPMEVDEPTDSPSIVNNNHFNKKKQSKLSILSPEPNDAKNNRSNKRHKKDNTRSDTLESLELHAPPSLELTTPTFNLTSSNTRTRRSTGRKINVDISDAIFKLPFEHGWKRELVYRTSGESTVLNRANRSGDVYYYSPNNRKLRSLREIQEQLDISSDKTSLTIDSFTFLKQPIGMNDRSKELIRDANSKLSKEDSFVGVAVRPKKSKTPVPRPPFDYELSDDENKKSASKMKIVFKNAKTSSRSRSKKGNSELMNTSSSTPEYISEDWQAIQSSVSPKVSPKLENKDTNNIIIKRRLSASDGEVIMQTPCGIRCPNSHEPATLMCTQCLVYYHPACVSLNANLKIVGYVCLNCRCIIRKRNHHVMLANSVIVDATELEQQLRVEPIRIRQVHQASDTPNFFIDRTPISKIEEPHEIDECSDESDSNNINTVICQGNVYKTTMVDGSFHEQYVYEMKQTRGPSLMTCVVQEPKNLEENSEMNGSYKEIVTPFASMQSFNYMVKALRHVFKYLKTHELLSASRVCTAWHIIAMNKFLWQNVRLKNSMVYDWERFVDSIDQQRSDTLDTRRMLIPVKVDEFENFWLHFSKAMKRAQKLKFIELYRCPTHVVEDIIYSLPQLEVLNATSIKNPNVTKEAKNANDFMTLNLNYLGQMTKLTELRLKGLTGIKLTSLPSFENLINLNKFSLTSIKSFPKDICQSLDTITDNLEFLEIGDCDCLSKDFAVSLKRFVNLKSLRLENCCGKWDSCAQDVFTVIRGLEKLTILELVNIEFSNCVEDELEKCVGIKALLIIPAYVSQSATTNCHLIDCLKKLSKTLTHLVWGLTHELLRVTDLFITQYQQNQHSIGYNLELSHTKETTNNIPILRTRKPRQRPGDEPAPEKDKDKDKSDNVDILSVPALEKLLDTMMPDAKTRVIKVPFSGTVRVYLSEQFNDL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00940496;
90% Identity
iTF_01328635;
80% Identity
-