Basic Information

Gene Symbol
MBD-R2
Assembly
GCA_944452905.1
Location
CALYCC010000064.1:2175301-2183053[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 2.3e-17 2e-13 50.7 0.3 6 69 195 258 190 266 0.91
2 2 2.1 1.8e+04 -3.7 0.0 41 64 834 856 831 859 0.76

Sequence Information

Coding Sequence
ATGCGTGAATTCGTAGCTGGCGAAAGAATTCTAGCGACTTGGGCTGACGGCAGGAAATATCCTGCTAAAGTAAAGACTGTGTTGGGAAATGACAGATACGACGTTCTATTCGACGATGGTTATGCCAAGATAGTCAGATCGTCGAAGATGACCAAAATTGCTACTACTACGGAAAAGAAGCCAATAGATGGGGATTATATAGGGAGTAAGCAAGAGAGGAGAGATAAGAAAAGAAAGCACAGCGTGATGGATCTGTTTCAATCCAACACCAAGAAACGGCCAAGAACCGATTCGGAAAAGTCGATAAAAAAGGAAGAGTCCTTGATAAGCGAAGACGACAACCAAGTCGAACTACCCGAGCTGACACCCGCGATTGCCTACGAGTCTGGCACGGAGGTACTCAAGGGATTCGAGCCTAGTAAACCCAAGGTTAAAACTTATGCTAAAAAAAAGAAAAAGGAAATATCTAAGATCGATACCGACAACGAAGACGAGGTAGTGCCGGAATGGATCGACGGCGAGCCCCAAGGGATAGAGTCTTACATCGTCGATGGTAATGACGGACCACGCCGGTCCATCATTGTGGCGGATAAAAGACTGCCACCTGGATGGCAGAAGCATTTTACTCAGAGAAGAACCGGAACTTCTGCTGGGAAGTGGGACGTTTTGTTTATACACAAATCAAGCGGCAAAAAGTTCAGATCGCGTAACGATATCAGATCATTTATGGAACATCAAGGACAGTTCGATTTCGAGCCAGAGAAATTTGACTTCTGTATACACCGTAAGAAGAACAGCAAGAATAGCGCTGCTAAATTGAAGCAGGAACAACCCACGGAAGTTCCGAAAAAAATCAAAACTCTTTTGCCCAAGACTAAAACACCGGCCAGCACTCCCGATCCTACACCTCTATGCATTGTACCGCCGCCTGTTCAGCCGCCACCAATTACTCCGGTCACACCCGCAGATCCTGGTGCTGTTTTCATCGGAGGACTACGAGTTGAAATGGAAGACAGTGCTTATAAATGTCCGAAAGAAGGTTGCAACAAGAATTTTCGTAAGGAGAATCTCCTTCAAATGCATATCAAGCATTATCACCCTGAGTATTCAAAGTTTTTGGGATCAACACCGAACGTAGCTGACTTGGCTTATGCCAGAACGATCGGCGAGTCGATCGAAGACATTATACCAAAGAAGCAGAACAACTTTTTGGAAAAGATAAACAAGTTTGAAAAGAAAAAAGCATCCCAAGAGAAACATGTGTCTGTTAATGAACCCGAATCGAACAGAACCGAAAAAATGTCCAATTCAACAAAAGAGGATTCCAAGTTCGAAGTCACATCGCCTATCTCAACCCAGAGCATCGACATAGATGATGATTTTATCAAAAAGAGGGAAGCCAGTTGCGCCATGTCCCCTGGGACGTTGTTCGACTTGAAAATCAGGGAAGAAAAAACTCAGACAGGGATTAAAACTTTGTTACCAGTTAGGCCGGCTCTTCCCGCTCCACTCGCTACCAACGTTGCTGCAGAATTGAGCAAATTAGACAGGTCCAAATCGTTGGACGAACCGTCAGTGTCCGAGAAAGGGAAGTCTATAAGGAAGCGGCAGATGTCGGAATACAATTCAGACGTACAAATCAAGTACAAGAAGAAACAAGGCATGCTGGAGCTTAAGGATGATTATGGGGATTTAGATGATGGTACTTTGGACATTGAGGAGCCGATTGCCCCTACGTACAGATTCAGTCGGAGAAAATCTGATCCGAAGAGTGATGAGAATAGTCAAACCAGTCAACTAAACGATTCTCATCTTGATAAAGGTGATACCCCTAAAGGGGATGCTGCCAAAAGAGATAATAGTAATGATACTGAAGATGGGGACGGTGTAATGATGATGATTAATGGTGAACTAGTCAAGGTGGAGCAGCTTCGCAGAGAAGAGATAATAAATTGTACATGTGGATTTATGGAGGAGGATGGATTAATGATTCAATGTGATCTTTGCCTTTGCTGGCAGCATGGACACTGCAATGCTATTGAAAGAGAGAAAGATGTGCCGGAAAAATACGTGTGCCACATTTGTCTCAATCCTTATAGACAGAGACCATCTAAGAAATACATTCACGATCAGGACTGGATTAAAGAAGGAAAATTGCCCAGCCTATCCAATCGCACCAAGAATCAATCTGCCATCGATCAAAGAACCGCCATGTTGAAGCGTTCGTATGATTTAGTCGCAGCATTGCTACAAATACAACAAATTCTTCACAGTCTGAGAGTGAAAATCAATGTCGCCGAAAAAAAGGATCATCCGAAATTATATCTTTGGGCAAAAAATTGGGAGAAAAGCGAGATACCAACACCGGATACCGATCCGGTGCCGATAATGGAAATAGTTAAACCATCTCTCGAGACGGCAGAGTCTAGTTTGGACAGTTCACCCACTACGGAAGTAAAAGTTGAAATAAAAGAAGAACCCAAGGAGGAGCCTGACGAGAAGTCAATCGCATCCAATTCGGAGCTGATGAAAATTTTAGAAGAAGATAGTCTGCATGCCGAGGAACTTAAGAATATTAAAAAACAGGAGAGCCAAAGCGAAGGTCATATTCTTTTGGAGGCATTGACCAGGAATAGTACAGACAAAATAGCCTCGGAACTGAAAACTGATAACAGCGAACCACCGAATAATCAGCCATCCACCTCGAAAACACCAGATCTGGTATCTTCAAATCCAACTGATAATATTGAGCACGAAGAGGCTCGTTTGAATGAAATTTTGCCACTGCAACCTTTCATACCGGAACCAGAAGCCCCGATAGACCCTGCTGAGTGTCGTTCAAGACTGCTGGACCACATTGATCATTTTCAAAACCACATAGATTCGCGGCTCATTACAATCGAGGCACAAGTTTCCGCTCTAGAGGCAATGGACCCAGATGATCCTATATCTAATCCTGATGTATTACCTCGGACAAAGCAAACCGTACAAATGCTACTCAGGGACTTGGCGACTGTTAGAAAATTGGCCTCACTTTGCTGA
Protein Sequence
MREFVAGERILATWADGRKYPAKVKTVLGNDRYDVLFDDGYAKIVRSSKMTKIATTTEKKPIDGDYIGSKQERRDKKRKHSVMDLFQSNTKKRPRTDSEKSIKKEESLISEDDNQVELPELTPAIAYESGTEVLKGFEPSKPKVKTYAKKKKKEISKIDTDNEDEVVPEWIDGEPQGIESYIVDGNDGPRRSIIVADKRLPPGWQKHFTQRRTGTSAGKWDVLFIHKSSGKKFRSRNDIRSFMEHQGQFDFEPEKFDFCIHRKKNSKNSAAKLKQEQPTEVPKKIKTLLPKTKTPASTPDPTPLCIVPPPVQPPPITPVTPADPGAVFIGGLRVEMEDSAYKCPKEGCNKNFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESIEDIIPKKQNNFLEKINKFEKKKASQEKHVSVNEPESNRTEKMSNSTKEDSKFEVTSPISTQSIDIDDDFIKKREASCAMSPGTLFDLKIREEKTQTGIKTLLPVRPALPAPLATNVAAELSKLDRSKSLDEPSVSEKGKSIRKRQMSEYNSDVQIKYKKKQGMLELKDDYGDLDDGTLDIEEPIAPTYRFSRRKSDPKSDENSQTSQLNDSHLDKGDTPKGDAAKRDNSNDTEDGDGVMMMINGELVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEREKDVPEKYVCHICLNPYRQRPSKKYIHDQDWIKEGKLPSLSNRTKNQSAIDQRTAMLKRSYDLVAALLQIQQILHSLRVKINVAEKKDHPKLYLWAKNWEKSEIPTPDTDPVPIMEIVKPSLETAESSLDSSPTTEVKVEIKEEPKEEPDEKSIASNSELMKILEEDSLHAEELKNIKKQESQSEGHILLEALTRNSTDKIASELKTDNSEPPNNQPSTSKTPDLVSSNPTDNIEHEEARLNEILPLQPFIPEPEAPIDPAECRSRLLDHIDHFQNHIDSRLITIEAQVSALEAMDPDDPISNPDVLPRTKQTVQMLLRDLATVRKLASLC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01200150;
90% Identity
iTF_00938692;
80% Identity
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