Basic Information

Gene Symbol
-
Assembly
GCA_905340355.1
Location
HG996555.1:5760596-5766993[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 4.2e-05 0.0012 20.0 2.3 3 23 174 194 172 194 0.97
2 12 0.00011 0.0031 18.7 1.7 1 23 200 222 200 222 0.98
3 12 9.2e-05 0.0026 18.9 2.1 1 23 271 293 271 293 0.98
4 12 2.6e-07 7.4e-06 27.0 3.4 1 23 304 326 304 326 0.99
5 12 0.00023 0.0066 17.7 1.6 1 23 332 354 332 354 0.94
6 12 2.1e-06 6e-05 24.1 1.1 1 23 360 382 360 382 0.97
7 12 2.3e-05 0.00068 20.8 0.4 1 23 388 410 388 410 0.95
8 12 0.00075 0.022 16.1 0.2 3 23 418 438 416 438 0.96
9 12 6.9e-06 0.0002 22.5 2.9 1 23 444 466 444 466 0.98
10 12 0.0003 0.0087 17.3 0.7 1 23 472 494 472 494 0.99
11 12 2.8e-06 8e-05 23.7 0.7 1 23 500 522 500 522 0.98
12 12 8.1e-07 2.3e-05 25.4 0.5 1 23 528 550 528 550 0.98

Sequence Information

Coding Sequence
ATGGAAGAAAGTTCATTAACGAATGTGTGTCGGGCTTGTATGACAGAGCAAGGTGAATTTCAGTCAGTTTTCATGAGCGACGAAAATAGTGGCTTGACGATTCATTTAGCTGAAATGATTATGGCGTATGCGTCTGTTCAAATCACATTCGGAGACGGACTGCCTGAACAAATTTGTACATCTTGTGCCGAGAAAGCTGTAAATTTGTATTTGTTTAAATTGTGTTGTGAGGAATCGGACACTTCGTTGCGACAACGTTTGGGTAAATCACCTTTGAATAAGATGTATAGCATAACCGAAGAGATGCTGGCGGCCGAGAAGCTTGAAAGGGAAGCTTTTATAAGTAGATTGATTAAACCGGAAGTTAGTATTGAAGAAATTAAAGATGAATCCGATAACGATTTTTCGAATATCGAGATTGTGGGTGCCGATGATTTGGATACGTCGCTGGAGGATTGTACTCAAGTGGAGACTGATGAATCGGAAGTAAAAAACGAGGGGACGAAACACGTAATATTTTGTGAAATTTGTAATAAGGGGTTTAATCGTGTAAGCCATTTAAATCGGCACAAAAAAATTCACCTTCCTCGTAAAATGTACCACTGTGACATTTGTAAGAAAGCTTTCACCAGAAACGATATTTTGATTCGTCACTTGAGTACCCACGACGATAAAGATTCAAACTCGGCTTATGAAATTTTAAAGGAAATTAAGAACGAAGATCAGGTTACTGCGTTTGAAAGTATCTTGGACGAGCAGGTCATGGTGGACAGTTTAATTGAAATCAAAGCGGAGGAAGAAGGTGACGATTACAGTTGTTCAGAATGTTACAGATCCTTTCAAAATAAGGACGATTTCAATTCTCATATGCAACTCCACGAAATTAAGATGAAAGGGACACCGGGAAATTATAAGTGTCCAAATTGTAACAAAAAGTTTAGTAAACCTTCTCACTTGACTCGACACGTAAAAATTCATGCAGCAGTTAAACCTTTCTTGTGCAAGTTGTGCCATAAGGGATTTGCTCGTAGCGAACAATTAAGCAATCATTTGAATGCGCATACTGGAATAAAACCGCACGTTTGTGGGAGCTGTGGTAAAGGTTTCAATCAAATATCCAATTTGAAAGACCACATGAGAACCCACAATGGTGAAAAGCCATACCTTTGTTCTGTCTGTGGGAAAGGTTTCAACCAACTGGGCAATTTACGACAGCACACCATCCGACACACAGGAGTCAAAGCTCATTTATGCAGTATTTGCGGAAATGGATTTGCCAGCAAAGGAGAACTGGGTGCTCATTTACGTAAACATACAGGGGCGCGACCTTTTGTGTGTTCAATTTGCAATCACGGTTTCACCACATCAAGTTCTCTAACGAAGCATAAACGTATCCACTCTGGAGAAAAGCCCTACGAATGTGAAGTGTGTAAAATGCGGTTTTCTAGATCCGGTATTTTAGCCCGCCATAAACGTACTCACACGGGGGAAAAACCCTACGTGTGCCAATATTGCTCAAAAGCCTTCTCTCAGTCGAACGACCTTAGTTCACATCTACGTATTCACACCGGTGAGAAGCCATACATTTGTGACATTTGTGGACAAGCCTTCCGGCAAAGTTCGGCTTTAAAAACGCATAAAAAAACTCACATAGATCGTTCTTCGATTTTGGAAATTGAGCGATCGAGAAATTTTGTTCCCATGATTCACAATTCATATGTGAATGTTTTACCGTGA
Protein Sequence
MEESSLTNVCRACMTEQGEFQSVFMSDENSGLTIHLAEMIMAYASVQITFGDGLPEQICTSCAEKAVNLYLFKLCCEESDTSLRQRLGKSPLNKMYSITEEMLAAEKLEREAFISRLIKPEVSIEEIKDESDNDFSNIEIVGADDLDTSLEDCTQVETDESEVKNEGTKHVIFCEICNKGFNRVSHLNRHKKIHLPRKMYHCDICKKAFTRNDILIRHLSTHDDKDSNSAYEILKEIKNEDQVTAFESILDEQVMVDSLIEIKAEEEGDDYSCSECYRSFQNKDDFNSHMQLHEIKMKGTPGNYKCPNCNKKFSKPSHLTRHVKIHAAVKPFLCKLCHKGFARSEQLSNHLNAHTGIKPHVCGSCGKGFNQISNLKDHMRTHNGEKPYLCSVCGKGFNQLGNLRQHTIRHTGVKAHLCSICGNGFASKGELGAHLRKHTGARPFVCSICNHGFTTSSSLTKHKRIHSGEKPYECEVCKMRFSRSGILARHKRTHTGEKPYVCQYCSKAFSQSNDLSSHLRIHTGEKPYICDICGQAFRQSSALKTHKKTHIDRSSILEIERSRNFVPMIHNSYVNVLP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2