Basic Information

Transcription Factor Domain

TF Family: LRRFIP
Domain: LRRFIP domain
PFAM: PF09738
TF Group: Unclassified Structure
Description: LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 3.7e-99 3.5e-95 317.8 24.5 20 300 1 278 1 278 0.97

2 3 0.0034 33 2.7 2.8 122 171 278 327 276 333 0.91

3 3 0.023 2.2e+02 0.0 4.1 195 233 310 347 290 353 0.50

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	3.7e-99	3.5e-95	317.8	24.5	20	300	1	278	1	278	0.97
2	3	0.0034	33	2.7	2.8	122	171	278	327	276	333	0.91
3	3	0.023	2.2e+02	0.0	4.1	195	233	310	347	290	353	0.50

Coding Sequence: ATGCGCGAATTGGAAAGACAACAAAAGGAAGCAGAAGAAAATGCTGATAGGGTTTATGACATGTGTTCAGATCCTAATAGAGCCATGAGAGTAACTCCAGATCCTGTGAGGACGTCACGTTTGCTCacaaattcgaataattttcaatccaGTTGTAAATCATCGGAAGATTCATTAGAAGATATAGGCCTTGGTAGAGATCTTAGGttAGAGTTGAAGGAATTTGAAGAGAAGTTTCGAAAAGCTATGATAGCTAATGCCCAATTagataatgaaaaatcttcttttGCATATCAAGTTGATatattgaaagataaattGGAAGAATTGGAAGAAATGGCAGCTCAATTGCGTAGAGAACTTCGAGAGAAGAATCGAGATGCCGAACAGTTAAAACGACTTAGTCAAAGATTAAAAGATGATTTAGATTTATGCAGAACACAGTTATTAGAAAGGGATACACTCATTCagGAAAATGGATTAGTAATAGTTGAAGATGAAGGTaccgatgaagaagaagatgttgAAGGTGGATCCTGCCATAGGAAAAGAGTATTAGTTAGTAAAGAATCTGcagatttattagaaaatgctGGCAAAGGATCCTTGGATGTTCGACTGAGAAAGTTCGCTtcggagaaaaaagaattagaagatCAAATACGACATTTAAGATTGGAATTAGAAGAAACCAAGAATCGCATAAGATCTGAGAGATCACCGGGTGCAGTATTAGGTGGCTTAACGGATTCTGAAGATATTCAACGAGAAGCTAATAAACTTTTAGCTGACTACAAATTCAAGCTGCAAAAGGCGGAACAAGACATGTCTACTTTACAAGCCACTGTAGCTAGATTAGAAAGTCAAGTAATACGCTATAAGTCGGCGGCAGAAGCATCTGAAAAGGCAGAGGATGAACTCaaagttgaaaaaagaaaattgcaaaGAGAAgtTAGAGAGTCTCAAGGACGTGTCGAAGAACTCGAAACAGCGAATTCTCATTTACAAAGGCGATTAGATAAACTTAAAAATGCTAAATCTGCTCTTTTTAAAGATCtttga
Protein Sequence: MRELERQQKEAEENADRVYDMCSDPNRAMRVTPDPVRTSRLLTNSNNFQSSCKSSEDSLEDIGLGRDLRLELKEFEEKFRKAMIANAQLDNEKSSFAYQVDILKDKLEELEEMAAQLRRELREKNRDAEQLKRLSQRLKDDLDLCRTQLLERDTLIQENGLVIVEDEGTDEEEDVEGGSCHRKRVLVSKESADLLENAGKGSLDVRLRKFASEKKELEDQIRHLRLELEETKNRIRSERSPGAVLGGLTDSEDIQREANKLLADYKFKLQKAEQDMSTLQATVARLESQVIRYKSAAEASEKAEDELKVEKRKLQREVRESQGRVEELETANSHLQRRLDKLKNAKSALFKDL

Sequence clustering based on sequence similarity using MMseqs2