LRRFIP
- Domain
- LRRFIP domain
- Group
- Unclassified Structure
- PFAM
- PF09738
- Desciption
- LRRFIP1 is a transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'- AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA [1]. LRRFIP2 may function as activator of the canonical Wnt signalling pathway, in association with DVL3, upstream of CTNNB1/beta-catenin [2].
- Rederence
-
- GCF2/LRRFIP1 represses tumor necrosis factor alpha expression. Suriano AR, Sanford AN, Kim N, Oh M, Kennedy S, Henderson MJ, Dietzmann K, Sullivan KE. Mol. Cell. Biol. 25, 9073-81, (2005).
- Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis. Liu J, Bang AG, Kintner C, Orth AP, Chanda SK, Ding S, Schultz PG. Proc. Natl. Acad. Sci. U.S.A. 102, 1927-32, (2005).
