Basic Information

Insect: Polistes canadensis
Gene Symbol: MBD-R2
Assembly: GCA_001313835.1
Location: NW:282897-293289[+]

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 1.8e-17 4.1e-14 51.0 0.4 6 69 536 599 531 607 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	1.8e-17	4.1e-14	51.0	0.4	6	69	536	599	531	607	0.91

Sequence Information

Coding Sequence: ATGAAGCGGCGGCGTATAGCGCGCTCGCGTGCTAAGAAGGGGCTACCGCCAACGGTGCCGATTATGAGAATGGCGCGCAAATGTTGCGTGCCCAACTGCAAGATTGACGTACAGGAGGCACGTAACAAGGGTCTACCCCTTCATAAATTTCCGAAGGACGCTGTACTTAGAGGCAGGTGGTTGACGGGTGCTCCTTTCGGTTCTAACTTCAAGCCGACGCCCGGTCAAATCATTTGTCATAGACATTTTAAACGTGCCGACTACGAAGCCGCCAATAAAACTAACAAGCTAACGTTGAAGAAAGGCAGCGTACCATCGGTATTTACCGACTATGATAACCACCCAGATCCGGTAATTATGTCTGTTAAGACCTCTACTTCCTATGCCCAAGAAGATCTGGATTTAATAAATGCTGAGATTTTAAATATGAGGCATTCTCCTTTATTATCAGAAGATAGGACTTCTAAGATTGATAGTACCAATGAGACATGTTATTCCAAACCAGAATCGTCAGCAGATTCAGTTAATTTATCAGAGACACCTAATTTAACGAGTCAGGAGTGCAAGTCGTCATCTGTGGAAAATGATTCGAGTATTAAAAAAGAGGAATCTTCTAATGATCCAGATGTTAAAGTAAACAGTATGGCGATTCAGTTGGGTATCGTTGAACCTGAAACAACGGTACAAAATGTTTCCAAAGATTTGATTCTAACAAAAGAATCAAATGGTCTTAAGGAAGTAAATGAGAAGGAATTGGATAAGGTTAACGATTCCAAAGCTAAAACGTTAAATCGTGGAAGTTTAAAATTCTTCCAAGGTGCCAAATTGGAAGCAAAAGATTTCAATGAAAAGTGGTATTCAGCTAAAGTAGTGGAAACAGAttgggaagagagagaagttttGATACATTTTGATAACTGGAGTGCAAGATACGATGAATGGATACCAATGGATAGTTCGAGACTACGAGTATTGCAAACAGTACctaaGGAAACCCCGAGCATGAAAGAGTTCGCAGTCGGAGAAAGGATCCTTGCTACGTGGGTGGATGGTAGAAAATATCCTGCTAAAGTAAACGCCGTCTTAGGGAATGatAAATACGACGTGCTATTTGATGATGGATATACAAAGATTATCAGGTCCTCGAAGATGACTAAATGCACCACCCCGCCCAAAACGCAACAACCAATTCGAGGAGATAGTTACATAGGAAGTAAACAAGAGAGAAgggacaagaaaagaaaacatacgGTCATGGAGCTGTTCCATACGCATTCTAGAAAACGTTCTAAACATGACGGTGATAAAACaactaaaaaagaagaatctgTTTCCCATAGCAATGTAGAAAGTTTCCCTGAATCAAAGTTCGATTTGGATGGCACTTTATTTGGACCTTGTTACGATCCTGGTACAGATTTATTAAGAGGATTTAACACAACTGTGCCTAAACCCAAACCAATaccaaagaaaaacaaaaaagaaatgcataaATCTGATACAGAGCAAGAAGAGCATGTTGGTCCAGCATGGATTGATGGCGAACCACAAGGGATTGAATCTTACATCGTAGATGGAAATGATGGACCACGTCGTTCTATTATTGTACATGATAAAAGATTACCACCGGGTTGGCAGAAACATTTTACTCAGAGAAAAGCTGGCAACTCTGCAGGAAAATgggatgttttatttatacaCAAATCGACTGGAAAAAAATTTAGATCGAGAAATGACATAAGGACATTTATGGAAAACAAAGGCCAGTTCGACTTTGATCCagagaaatttgatttttgtattCACCGTAAGAAAAGGAATCATGCGTCAAAGTTAAAGCAAGAACATACTACACCAGAAGTTccaaagaagataaaaacatTATTGCCCAAAGTAAAAACACCAGTTCCTAATGAAAATACATTGCTTGCGTCATTTAACACTCCAGTTAATATACCAGTTACATCCCCAGGAATTACTGGAACTCCCATTAATAATGgaggAGCGATTTAttCAGCTGTATTCATTGGAGGCCTTCGAGTAGAAATGGAAGACAGCGCCTATAAGTGTCCTAAAAAAGGATGTAATAAAACTTTtaggaaagaaaatcttttgcaAATGCATATAAAGCATTATCATCCAGAGTATTCGAAATTTTTGGGTTCCACGCCAAATGTTGCAGATCTGGCATATGCAAGAACAATCGGAGAGTCCGTAGAAGACattattccaaaaaaatcGACACCTCTATTAGACAAAGTTcataaatttggaaaaaagaaagcttCTCAAGAAAGATCACCAGCAACTCTGACGCAACCGGGATTAAATTTTGTACAACCTTCTTCTCCATTTGTATCGGTACCATCATTTGAGGAACGAGAAGATGAAGTTAATCATGTAGagaaatttaatgatttacataaagaagataaaatagaaacaatgTCACCTATGTCAAATCATAGCATAGAAATAGATGAAGatattgagaaaagaaaagaaaattcgtgtGCCATGTCACCGGATACATTGTTTGATATGAAAATTAGAGAAGAGAGACCAGAGAAAGTTGGAATTAAGACATTATTACCTGTTGTTCGACCACCTGTGACATCAGAAGTACAAAGGGTCGATAGATCTAAGTCTTTAGATGATCCTCTGCATATCGAAAAGGGTAAAGGTCAAAGAAAACGTCAGTTATCTGAATATAGTTCAGATGTTCCatctaaaggaaaaaaacgacATGGTATGCCAGATATTGTAGATGATTATGGTGATCTTGATGACAGTGCACTTGATGCAGAAGGTCCTACTGCTCCTATGTATAGGTACAGTCGTAGGAAATCTGATTGTAAAAGTGACGAAAATAGTCAGAATAGTCAACTTAATGACTCTCGCCTTGAGAAAGGCGACCCCTTAAAAGGGGATTCTGCAAAAAGAGATATTAGTAATGATGCGGAAGaaagcGAAGGAgttatgatgatgattaacGGAGAAATGGTCAAAGTAGAGCAACTTAGgcgagaagaaataataaattgcacTTGTGGATACATGGAAGAGGATGGTTTAATGATACAATGTGATCTTTGCTTATGTTGGCAACATGGTCATTGCAAttccatagaaaaagaaaaagatgttcCCGAAAAATATGTTTGTTATATATGCCGTAATCCGTATCGAGAAAGGccatcgaaaaaatattatcatgatCAAGATTGGATAAAGGAAGGCAAATTGCCTAGTTTATCTACCCGaacgaaaaatcaaaatacaataaatacaaGAACTGCGATATTAAAGCGTTCGTACGATTTAGTCTCAGCTTTATTGCAAATGCAACAAATACTTCGTAGCCTGAGGGTGAAAATAAACGTAGCGCagAAAAAAGATCATCCAAAATTATATCTTTGGGCCAAAAATTGGGAAAAATTGGATGTACCTAAACCCGACACGGAACCTGTTCCTgtaatggaaataataaaaacaccTGTAGATTTTATCGATACAAGTTCAGAAACTTCTAGACGTAccgatattaaaatagaaactaAAACATCCGTTAAGGATGATCACGATGACAAATCAATAGCCTCGGATTcggaattaatgaaaattttagaAGAAGATAGCTCTAATTCCGACGAATCTAAAGTGATGTGTAAAAAAGAGGATTTGGCTAATTCAAAAGGTggcaatatattattagacgCGTTAACAAGAAATGGAAGTCAAaatgagaaacaaaaattgaagcTTGAAAATTTAACAGAAAACATAAaTACACATGGATCGGAAGATAGCAAATCGGCGTCAGGATTATTCGCGGATAATATTCATGGTGAAACAGATGTACCTGAAATTGGGCAGGAATTATTAACTTCTTTACAACCATTTATACCAGAACCAGAAGCACCTATAGATTCTGCTGAATGTCGAATGAGATTATTGGAACACATTGAACATTTCCAAAGTCACATAGAATCAAGATTAATATCATTAGAAGCTCAAGTTACTGctTTGGAAGCTATGGATTCTGACGAGATCATACCGAGTCCTGATGTGCAACCACGAACGAAGCAAACAGTGCAAATGTTGCTTAGAGATTTGAATACAGTTCGTAAATTAGCTGCTTTATGTTAA
Protein Sequence: MKRRRIARSRAKKGLPPTVPIMRMARKCCVPNCKIDVQEARNKGLPLHKFPKDAVLRGRWLTGAPFGSNFKPTPGQIICHRHFKRADYEAANKTNKLTLKKGSVPSVFTDYDNHPDPVIMSVKTSTSYAQEDLDLINAEILNMRHSPLLSEDRTSKIDSTNETCYSKPESSADSVNLSETPNLTSQECKSSSVENDSSIKKEESSNDPDVKVNSMAIQLGIVEPETTVQNVSKDLILTKESNGLKEVNEKELDKVNDSKAKTLNRGSLKFFQGAKLEAKDFNEKWYSAKVVETDWEEREVLIHFDNWSARYDEWIPMDSSRLRVLQTVPKETPSMKEFAVGERILATWVDGRKYPAKVNAVLGNDKYDVLFDDGYTKIIRSSKMTKCTTPPKTQQPIRGDSYIGSKQERRDKKRKHTVMELFHTHSRKRSKHDGDKTTKKEESVSHSNVESFPESKFDLDGTLFGPCYDPGTDLLRGFNTTVPKPKPIPKKNKKEMHKSDTEQEEHVGPAWIDGEPQGIESYIVDGNDGPRRSIIVHDKRLPPGWQKHFTQRKAGNSAGKWDVLFIHKSTGKKFRSRNDIRTFMENKGQFDFDPEKFDFCIHRKKRNHASKLKQEHTTPEVPKKIKTLLPKVKTPVPNENTLLASFNTPVNIPVTSPGITGTPINNGGAIYSAVFIGGLRVEMEDSAYKCPKKGCNKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESVEDIIPKKSTPLLDKVHKFGKKKASQERSPATLTQPGLNFVQPSSPFVSVPSFEEREDEVNHVEKFNDLHKEDKIETMSPMSNHSIEIDEDIEKRKENSCAMSPDTLFDMKIREERPEKVGIKTLLPVVRPPVTSEVQRVDRSKSLDDPLHIEKGKGQRKRQLSEYSSDVPSKGKKRHGMPDIVDDYGDLDDSALDAEGPTAPMYRYSRRKSDCKSDENSQNSQLNDSRLEKGDPLKGDSAKRDISNDAEESEGVMMMINGEMVKVEQLRREEIINCTCGYMEEDGLMIQCDLCLCWQHGHCNSIEKEKDVPEKYVCYICRNPYRERPSKKYYHDQDWIKEGKLPSLSTRTKNQNTINTRTAILKRSYDLVSALLQMQQILRSLRVKINVAQKKDHPKLYLWAKNWEKLDVPKPDTEPVPVMEIIKTPVDFIDTSSETSRRTDIKIETKTSVKDDHDDKSIASDSELMKILEEDSSNSDESKVMCKKEDLANSKGGNILLDALTRNGSQNEKQKLKLENLTENINTHGSEDSKSASGLFADNIHGETDVPEIGQELLTSLQPFIPEPEAPIDSAECRMRLLEHIEHFQSHIESRLISLEAQVTALEAMDSDEIIPSPDVQPRTKQTVQMLLRDLNTVRKLAALC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01232440; iTF_01513474; iTF_01512228; iTF_01514156; iTF_01513522; iTF_01512185; iTF_01514202; iTF_01512872; iTF_01512829; iTF_01514824; iTF_01514865; iTF_01089995; iTF_01090042; iTF_01233703; iTF_01235026; iTF_01233655; iTF_01235070; iTF_01234344; iTF_01234389; iTF_01233043; iTF_01232997;
90% Identity: iTF_01232440;
80% Identity: iTF_01232440;