Vger010696.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Vespula germanica
Gene Symbol
MBD-R2
Assembly
GCA_905340365.1
Location
HG996545.1:4722803-4731232[+]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.5e-17 1e-13 50.4 0.2 8 69 542 603 536 611 0.91

Sequence Information

Coding Sequence
ATGAAGCGGCGGCGTATAGCGCGCTCGCGTGCTAAGGGGGTACCGCCTGCGGGGGCGATGAGAATGGCGCGCAAATGTTGCGTGCCCAACTGCGAGATCGACGTTCAGGAGGCACGTACCAAGGGTTTGCCGCTTCATAAATTTCCGAAGGACACTGTACTTAGAGGCAGGTGGTTGACGAGCGGTGGTTTCAAGACGAGCTTCAAGCCGACGCCCGGTCAAGTCGTCTGCCACAGACATTTTAAACGTGCCGACTACGAAGCCGCCAACAAAACTAACAAGCTATCGTTGAAGAAAGGCAGCGTTCCCTCGGTCTTTGCGGACTATGACAACCATCCAGATCCAGTGATCATGTCAGTAAAGACCTCTACTTCTTACGCGCAAGAAGATCTGGATTTAATTAATGCGGAAATTCTAAACATGAGACATTCTCCTTTAATATCCGAAGATAGAACTTCCAAGTCGGACAGTTGCGGCGAAACCTGTTATTCCAGACCAGAATCATCCGCCGATTCAGTTAATTTGTTAGAGACGTCCGATTTAATGGAGCAGAGGTGCAAGCTATCTAAGAGAAAGGATTCGAGtattatgaaagaagaaactcTCGACGACAcggaaataaaagtaaacagTATGGCGATTCAATTGGGTATAGTCGAACCTAAAATAGAGATGCAACACGTTTCCAAAGATTTAATCCTCAAAACTGAATTAAATGGTTTTAAGGAAGTAAATGAGAAAGAATTCGACAAAGTAAACAATTTGAAAACCAAAATGTTAAATCGTGACAGTTTGAAATTCTTCCCTGGTGCCAAATTGGAAGCAAAGGACTTCAATGAAAAGTGGTATTCTGCTAAAGTAGTGGAAACAGATTGggtagagagagaagtatTGATACATTTTGATAAGTGGAGTGCAAGATTTGACGAGTGGATACCAATGGATAGTTCCAGATTACGAGTATTACAAACGGAAAcaaaCGAGCGAACTTGGGTGCTGCCATCTCCGGAGGCGAACATGAGAGAGTTCTCGGTGGGAGAAAGGATCCTAGCTACGTGGGCGGATGGTAGAAAATATCCCGCTAAAGTAAACGCCGTCTTAGGGAATGACAGGTATGATGTGCTCTTTGATGATGGATATGCAAAGATTGTCAGGTCCTCGAAGATGACTAAAATTGCCACTCCGCCCGAAACgCAACCAGTTCAAGAAGACGGATATATAGGAAGTAAACAAGAGAGAagggacaaaaaaagaaagcatacCGTTATGGAGCTTTTCCATACTCATTCTAGGAAACGTTCTAAGAATGAAGGTGATAGaatagtaaagaaagaagaatccaTTGTTCGAAACAATATAGAAAGTTTCCCGGAATCTAAGATTGATTTGGATGGCACCTTATTTGGGCCTTGCTATGATCCTGGTACTGATTTATTAAAAGGATTCAATACAAACGTGCCTAAAACCAAACCGTTACCGAAGAAAgccaaaaaagaaatgcataaATCTGATACAGAGCAAGAAGAATATGTCGGTCCAGCATGGATTGATGGTGAACCGCAAGGAATTGAATCTTACATTGTAGATGGAAACGATGgGCCACGTCGTTCTATTATTGTACCTGATAAAAGATTACCTCCAGGCTGGCAGAAGCACTTCACTCAAAGAAAAGCTGGAACGTCCGCGGGAAAATGggatgttttatttatacacaAATCTAGCGGAAAGAAATTTAGGTCAAGGAACGATATCAGGGCGTTTATGGAAAGCCAAGGCCAGTTCGACTTTGATCCAGAGAAATTCGATTTCTGTATACaccgtaaaaaaaagaatcatggGCAAAAGTTAAAACAAGATGTTCCTACACCAGAAATaccaaagaagataaaaacgtTGTTGCCTAAAGTAAAAACACCAACTTCTAATGAAAATACATTACTTATGTCAGTTAACACGCCAGTTAATACACCAGTTACATCCGCAGGAACTACTGGAACTCCTGTTAATAACGGCGCTGTTTTCATCGGCGGGCTTCGAGTGGAGATGGAAGATAGTGCTTACAAATGTCCTAAACAAGGATGtaataaaacttttcgaaaagaaaatcttttgcaAATGCACATAAAGCATTATCATCCTgaatattcgaaatttttgGGATCCACACCAAATGTTGCAGATTTGGCATATGCAAGAACGATCGGGGAATCTATTGACGACATTATTCCAAAGAAATCGACTCCTTTAAtggaaaaaattcataaatttgGGAAGAAGAAGACTCCTCAAGAAAAATCACCAGGACCCACGTCGCAGTCAGGGTTAAATTTTGTACAGCCTTCTTCTCCATCCGTATCGTTAACAACGTTCGAGGAACGAGAAGACGAAATCGACCaattagaaaaagtaaatgagCTTCAtaaagaagatattaaaatagaaaccATGTCACCTATTTCAAGTCACAGTATGGAAGTAGATGACGaggttgaaaaaagaaaagaaaattcatgcGCGATGTCACCGGGAACATTGTTCGAtatgaaaataagagaagaaaaaacggagaaagttggtattaaaacattattacCTGTTCGGCCACCCGTGACACCGGAAGTACAAAGGGTGGACAGATCGAAGTCTTTAGATGATTCGATGCATATTGAAAGAGGTAAAGGTCAGAGAAAACGTCAGTTGTCGGAATATAGTTCTGATGTACCGTCTAAAGGGAAAAGACGGCATGGTATGCAAGACATCGTAGACGATTACGGAGATTTAGATGACAGTGCTGTAGATGCAGAAGGTCCTACCGCTCTTATGTATAGATACAGTCGTAGGAAATCCGACTCTAAAAGCGATGAAAATAGTCAAAATAGTCAACTTAATGATTCTCGCCTTGAAAAAGGCGACCCCTTTAAAGGGGATTCTgcaaaaagagataatagtaatgatgCAGAAgaaagcGAGGGAGTTATGATGATGATTAACGGAGAAATGGTAAAAGTAGAGCAGCTTCGacgagaagaaataattaactGCACCTGTGGGTTTATGGAAGAAGATGGTTTAATGATACAATGTGACCTTTGTTTGTGTTGGCAACATGGTCACTGTAATgccattgaaaaagaaaaagatgttcCAGAAAAGTATGTTTGTTATATATGCCGACATCCGTACCGTGAACGGccttcgaaaaaatattatcacgaTCAAGATTGGATAAAGGAAGGCAAATTGCCAAGCTTATCTACTCGAACGAAGAATCAAAATGCAATTAACAAAAGAACTGCGATATTAAAGCGTTCGTACGATTTAGTTGCAGCCTTATTGCAAATGCAACAGATTCTCCATAGTCTGAGGGTGAAAATTAACGTAGCTCAgaAAAAAGATcatccgaaactatatcttTGGGCTAAAAATTGGGAAAAGTTGAATGTGCCCAAGCCTGATACGGAACCTGTTCCAGTAATGGAAGTAATGAAAACGCCTATAGATTCTACCGATACAAGCTCTGAGACCTCTAGACGTaccgatataaaaatagaaacgaaagcaTCTGTGAAAGATGATCACGATGATAAATCGATAGCCTCTGATTcggaattaatgaaaattttagaaGAAGATAGCTCGAATTCGGACGAATCGAAAGTTatgtgtaaaaaagaagattcgatAAATTCAAACGGCGGGCATATATTATTAGACGCGTTAACAAGAGATGGAAGTCCggacgaaaaacaaaaattaaaccTTGAAAAtgcaatagaaaatataaATACGAATGGTTCGGAAGATAACAAATCGATATCTGGATTGTTCGTGGACAGTCTACATGGTGAAACTAATGTACCTGAAATTGGACAGGAATTGTCAACTCCGTTGCAACCATTTATACCAGAACCAGAAGCACCGATTGATTCGGCCGAATGTCGAATGAGATTACTGGAACATATCGAACATTTCCAGAGTCACATAGAGGCGAGACTAATATCTATAGAAGCTCAAGTTTGCGCTTTGGAAGCTATGGATCCTGATGAGATAATACCTAGTCCGGATGTGCAACCTCGTACGAAGCAAACGGTACAAATGTTGCTTAGAGATTTGAACACAGTTCGTAAATTGGCTGCTTTATGTTAA
Protein Sequence
MKRRRIARSRAKGVPPAGAMRMARKCCVPNCEIDVQEARTKGLPLHKFPKDTVLRGRWLTSGGFKTSFKPTPGQVVCHRHFKRADYEAANKTNKLSLKKGSVPSVFADYDNHPDPVIMSVKTSTSYAQEDLDLINAEILNMRHSPLISEDRTSKSDSCGETCYSRPESSADSVNLLETSDLMEQRCKLSKRKDSSIMKEETLDDTEIKVNSMAIQLGIVEPKIEMQHVSKDLILKTELNGFKEVNEKEFDKVNNLKTKMLNRDSLKFFPGAKLEAKDFNEKWYSAKVVETDWVEREVLIHFDKWSARFDEWIPMDSSRLRVLQTETNERTWVLPSPEANMREFSVGERILATWADGRKYPAKVNAVLGNDRYDVLFDDGYAKIVRSSKMTKIATPPETQPVQEDGYIGSKQERRDKKRKHTVMELFHTHSRKRSKNEGDRIVKKEESIVRNNIESFPESKIDLDGTLFGPCYDPGTDLLKGFNTNVPKTKPLPKKAKKEMHKSDTEQEEYVGPAWIDGEPQGIESYIVDGNDGPRRSIIVPDKRLPPGWQKHFTQRKAGTSAGKWDVLFIHKSSGKKFRSRNDIRAFMESQGQFDFDPEKFDFCIHRKKKNHGQKLKQDVPTPEIPKKIKTLLPKVKTPTSNENTLLMSVNTPVNTPVTSAGTTGTPVNNGAVFIGGLRVEMEDSAYKCPKQGCNKTFRKENLLQMHIKHYHPEYSKFLGSTPNVADLAYARTIGESIDDIIPKKSTPLMEKIHKFGKKKTPQEKSPGPTSQSGLNFVQPSSPSVSLTTFEEREDEIDQLEKVNELHKEDIKIETMSPISSHSMEVDDEVEKRKENSCAMSPGTLFDMKIREEKTEKVGIKTLLPVRPPVTPEVQRVDRSKSLDDSMHIERGKGQRKRQLSEYSSDVPSKGKRRHGMQDIVDDYGDLDDSAVDAEGPTALMYRYSRRKSDSKSDENSQNSQLNDSRLEKGDPFKGDSAKRDNSNDAEESEGVMMMINGEMVKVEQLRREEIINCTCGFMEEDGLMIQCDLCLCWQHGHCNAIEKEKDVPEKYVCYICRHPYRERPSKKYYHDQDWIKEGKLPSLSTRTKNQNAINKRTAILKRSYDLVAALLQMQQILHSLRVKINVAQKKDHPKLYLWAKNWEKLNVPKPDTEPVPVMEVMKTPIDSTDTSSETSRRTDIKIETKASVKDDHDDKSIASDSELMKILEEDSSNSDESKVMCKKEDSINSNGGHILLDALTRDGSPDEKQKLNLENAIENINTNGSEDNKSISGLFVDSLHGETNVPEIGQELSTPLQPFIPEPEAPIDSAECRMRLLEHIEHFQSHIEARLISIEAQVCALEAMDPDEIIPSPDVQPRTKQTVQMLLRDLNTVRKLAALC*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01232400;
90% Identity
iTF_01514156; iTF_01513522; iTF_01514202; iTF_01514865; iTF_01514824; iTF_01512185; iTF_01512228; iTF_01512829; iTF_01512872;
80% Identity
iTF_01513522;