Basic Information

Gene Symbol
MBD2
Assembly
GCA_947397865.1
Location
OX377618.1:55130491-55132187[-]

Transcription Factor Domain

TF Family
MBD
Domain
MBD domain
PFAM
PF01429
TF Group
Unclassified Structure
Description
The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 2 3.4e-25 5.3e-21 75.8 0.0 1 73 9 76 9 80 0.94
2 2 2.5e-05 0.4 12.1 0.0 27 73 178 233 167 237 0.84

Sequence Information

Coding Sequence
ATGCAAATGAACTCGAATATTTCAATAGAACGTAAAAAAATAGATTGCAATGTCTTGCCAAAAGGTTGGCAGAGAGAAGAGATTTTGCGTAAATCTGGAATATCTGCTGGAAAAGTTGATGTCTACTATTATAGTCCTACCGGAAAACGCATTGATAGTAAACCTCAATTAGCCCGACATTTAGGAGACGCCATTGACATAAGCAGTTTTGATTTTCAAAAAGGAAAATTTATACAGCATCTACCAGCACCACCATCAATATCTTTATATCGTTGTTTGCCGGGAACCTCAATTAGTGCTGCTAATGTTGGTGGTTGTAGTGTTGGTGCCAATTTACCAGCTGGTATTACAATAGTACCCCAGACATCGTCGGGGCACTCATTAAAGCGCAAGCATAAATCACCTCTGCAAACTACTACATTGTCTTCTTCTACGACCTCCAGTTATAACCTGTTGAGTTCTTGTACAACGACGTCACCGTCGTCTAATTTACCACCATCCAATCTAAAGCAACAACAGTTAGAATTCAGCCGTGCAATGCGAACAGACGTTTCGCTTGTTCCACCCATACGTCAAACGGCATCAATATTTAAACAGCCAGTTACAGTCGTACGTAATCATGAAAACAACAAGGTGAAACACGATACCAAACAAGGAGCCCAAGACAAACCTAAGCAACTCTTCTGGGAAAAGCGTCTAGAGCACATGCGCGCATGCCATGCTACAGGTGAACAATTCGACGATATAGTTTTGCCTAAAAGTCTTAAGCCATTGGGTCCTAATATCCATGAACAGACAGTTATGCAATCTTTGGCAACAGCATTACACGTACTCAATACACCTGTCACTGGACAAACTGCCACAAAGACTGAATTTCAAAAAAATGCCGCAGCATTCATTAACCCCGACCAGCCGTTAATGCAGGGTATACTCATATCGGAGGATGACATACGACGGCAAGAAGATCGTGTAACTATAGCACGAAGAAAATTACAGGAAGCCTTAAAGGCTTGA
Protein Sequence
MQMNSNISIERKKIDCNVLPKGWQREEILRKSGISAGKVDVYYYSPTGKRIDSKPQLARHLGDAIDISSFDFQKGKFIQHLPAPPSISLYRCLPGTSISAANVGGCSVGANLPAGITIVPQTSSGHSLKRKHKSPLQTTTLSSSTTSSYNLLSSCTTTSPSSNLPPSNLKQQQLEFSRAMRTDVSLVPPIRQTASIFKQPVTVVRNHENNKVKHDTKQGAQDKPKQLFWEKRLEHMRACHATGEQFDDIVLPKSLKPLGPNIHEQTVMQSLATALHVLNTPVTGQTATKTEFQKNAAAFINPDQPLMQGILISEDDIRRQEDRVTIARRKLQEALKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2