Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1.6e-23 1.5e-19 71.0 0.0 2 72 10 74 9 78 0.89

2 2 1.6e-05 0.16 13.2 0.0 27 73 172 227 152 231 0.82

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1.6e-23	1.5e-19	71.0	0.0	2	72	10	74	9	78	0.89
2	2	1.6e-05	0.16	13.2	0.0	27	73	172	227	152	231	0.82

Coding Sequence: ATGCAAATGAACTCGAATATAACAATAGAACGTAAAAAAATAGATTGCAATGCTTTGCCAGGTTGGAAAAGGGAGGAAGTTTTGCGAAAATCGGGAATATCAGCTGGGAAAGTTGATGTATATTATTACAGTCCTACCGGAAAACGTATTGATAGTAAACCACAATTAGCGCGATATTTAGGAGATGCCATAGACATAAGCAGTTTTGATTTTCAAAAGGGAAAATTTATACTGCACTTACCATCACCATCAATATCCTTATATCGCTGTTTGCCAGGAACCAACATTAGTGCTAGTCCAGGCggaagtagcagcagcagcattaCAATAGTGCCACAAACCTCCATCTCCTCCACGGGGCACTCATTAAAGCGCAAACATAAGTCACCACTACAAACGACTACTTTGTCACCTACGTCCTCCAGTTATAATGTATTAAGTTCTGGTACAACGACGTCGTCGTCGTCGATTATACCATCAACCCACCTAAAGCAACAACAATTAGAATTCAGCAGGGCAATGCGAACAGACGTTTCACTCGTTCCACCCATACGTCAAACGGCATCTATTTTCAAACAACCCGTGACAGTGATTCGCAACCATGAAGGGAGCAAGGTTAAGCATGACACCAAACAAGGTGCTCAAGACAAACCCTATCAACTCTTTTGGGAAAAACGTTTGGAGAACATGCGAGCTTGTCATGCCACAGGCGAACAATTTGATGATATAATTCTGCCCAAGAGTCTCAAGCCATTGGGACCAAATATTCATGAACAGACTGTTATACAATCGCTGGCCACAGCTTTGCACGTACTCAATACACCTGTAACAGGACAAACTGCAACAAAGACTGAGTTTCAAAAAAACGCCACAGCTTTTATTAATCCAGACCAGCCCTTAATGCAGGGTATACTCATTTCAGATGACGACATACGACGCCAAGAGGATCGCGTGAACCTGGCACGAAGGAAATTGCAAGAAGCTTTAAAGGCTTGA
Protein Sequence: MQMNSNITIERKKIDCNALPGWKREEVLRKSGISAGKVDVYYYSPTGKRIDSKPQLARYLGDAIDISSFDFQKGKFILHLPSPSISLYRCLPGTNISASPGGSSSSSITIVPQTSISSTGHSLKRKHKSPLQTTTLSPTSSSYNVLSSGTTTSSSSIIPSTHLKQQQLEFSRAMRTDVSLVPPIRQTASIFKQPVTVIRNHEGSKVKHDTKQGAQDKPYQLFWEKRLENMRACHATGEQFDDIILPKSLKPLGPNIHEQTVIQSLATALHVLNTPVTGQTATKTEFQKNATAFINPDQPLMQGILISDDDIRRQEDRVNLARRKLQEALKA

Sequence clustering based on sequence similarity using MMseqs2