Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 3.4e-27 9.7e-24 82.5 0.0 1 72 9 75 9 80 0.95

2 2 0.00027 0.78 9.1 0.0 27 73 189 244 172 248 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	3.4e-27	9.7e-24	82.5	0.0	1	72	9	75	9	80	0.95
2	2	0.00027	0.78	9.1	0.0	27	73	189	244	172	248	0.83

Coding Sequence: ATGCAAATGAGCTCGAATATTTCAATAGAACGTAAAAAAGTCGATTGCAATGCCTTGCCAAAGGGGTGGCAAAGGGAAGAAGTCCTTCGAAAGTCTGGAATCTCAGCAGGAAAAGTTGATGTCTACTATTACAGTCCCACCGGAAAACGCATTGATAGTAAACCCCAATTAGCTCGTTATTTAGGAGACGCCATAGACATAAGcagttttgattttcaaaaggGAAAATTTACAATGCAATTGCCACCACCATCAATTTCGTTGTATCGTTGCTTGCCAGGAACATCGATTAGTGCTAGTACTGCTCCAGTTGGGTGTGGTATTGGCGGCGGTACAAGCAGCAGCACAAGCAGTATTACAATTGTGCCACAACCGTCAACGGGACACTCTTTAAAACGTAAACATAAATCGCCGTTGCAATCTTCTGCATCCTCAACAAGCTATAATATATTGAATTCAACTACTGCAACGACTTCATCATCgttgtcgtcatcatcgtccGCCACGACTTCTTCGAATTTGTCAACGTCTAAtctaaagcaacaacaacagttagAATTCAGCCGTGCTATGCGTACCGATGCCTCCTTGGTTCCACCCATACGTCAAACGGCATCTATATTCAAACAACCTGTTACCGTGGTACGCAATCATGAATGGAATAAAGTAAAACATGACACCAAACAGGTGGCTCAAGACAAACCCAAACAGCTGTTTTGGGAGAAACGTTTGGAAAATATGCGAGCCTGTCATGCCACTGGAGAAGAATTCGATGATATTGTATTACCAAAGAGTATTAAGCCGTTGGGTCCCAATATACATGAACAGACTGTTATGCAATCCTTGGCCACAGCTTTACATGTCCTCAATACACCTGTCACCGGACAAACTGCCACTAAGACTGAGTTTCaaaaaaaCGCCACAGCTTACATTAATCCCGATCAACCGCTAATGCAGGGGGTACTCATTTCAGAAGATGATATACGACGGCAGGAGGATCGTGTAAACTTGGCCCGAAGGAAATTACAAGAAGCTTTAAAGGCTTAA
Protein Sequence: MQMSSNISIERKKVDCNALPKGWQREEVLRKSGISAGKVDVYYYSPTGKRIDSKPQLARYLGDAIDISSFDFQKGKFTMQLPPPSISLYRCLPGTSISASTAPVGCGIGGGTSSSTSSITIVPQPSTGHSLKRKHKSPLQSSASSTSYNILNSTTATTSSSLSSSSSATTSSNLSTSNLKQQQQLEFSRAMRTDASLVPPIRQTASIFKQPVTVVRNHEWNKVKHDTKQVAQDKPKQLFWEKRLENMRACHATGEEFDDIVLPKSIKPLGPNIHEQTVMQSLATALHVLNTPVTGQTATKTEFQKNATAYINPDQPLMQGVLISEDDIRRQEDRVNLARRKLQEALKA

Sequence clustering based on sequence similarity using MMseqs2