Basic Information

Transcription Factor Domain

TF Family: MBD
Domain: MBD domain
PFAM: PF01429
TF Group: Unclassified Structure
Description: The Methyl-CpG binding domain (MBD) binds to DNA that contains one or more symmetrically methylated CpGs [2]. DNA methylation in animals is associated with alterations in chromatin structure and silencing of gene expression. MBD has negligible non-specific affinity for DNA. In vitro foot-printing with MeCP2 showed the MBD can protect a 12 nucleotide region surrounding a methyl CpG pair [2]. MBDs are found in several Methyl-CpG binding proteins and also DNA demethylase [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 1e-25 6e-22 77.4 0.0 1 73 9 76 9 80 0.95

2 2 7.1e-05 0.42 10.6 0.0 27 73 204 259 192 263 0.83

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	1e-25	6e-22	77.4	0.0	1	73	9	76	9	80	0.95
2	2	7.1e-05	0.42	10.6	0.0	27	73	204	259	192	263	0.83

Coding Sequence: atgcAAATGAACTCGAATATATCAATTGAACGTAAAAAAGTGGACTGCAATGCCCTGCCCAAAGGATGGCAAAAAGAAGACGTTTTAAGAAAGTCTGGAATCTCAGCGGGGAAAGTTGATGTCTACTATTACAGTCCTACTGGAAAACGTATTGATAGTAAACCGCAACTGGCACGTTATTTAGGAGATGCCATAGATATAAGCagttttgattttcaaaaaggCAAATTTATACAACATTTGCCATCACCCTCTATATCCCTATACCGTTGTATACCTGGTAATTCAGCTGTGGTCAGCAGTAGTGGTGCGAGTACTAGTGGTAGTGCTGGAATTACCTTGGCTGCTGCTGGTAGTGGTTCTACTACACTACCGACATTGGGTGGCGGTATTACTATAATACCCTCACATCATTCATCAGCTGGCCACAATTTAAAGCGTAAAAATAGAATGGGATCACAATCTGCACTTCAAAACTTACCCTCATCGTCTTCCACTTCGATTTCCAGTCATCataatcttttattaaattcttgcACAACGCCGACCTTGATGACAACGACAACATCAACAAATTTGCCATTTAAGCAACAGCAATTAGAATTCAGTCGTGCTATGCGAACAGATATATCTATGGTGCCGCCCATACGCCAGACAGCATCAATATTTAAACAACCCGTTACAGTAATACGGAATCATGAGGGTAGCAAGACAAAAAACGATGCCAAACAAGGAGCACAAGATAAaccaaaacaattattttgggAAAAACGATTGGAGCACATGAGAGCTTGTCATTCAACCGGTGAACAAGTTGATGATATTGTACTGCCCAAGAGTCTAAAGCCCTTAGGACCAAATGTGCACGAACAGACTGTTATGCAATCACTTGCCACTGCTTTGCATGTACTCAATACGCCCGTGACTGGACAAACCGCAACAAAGactgaatttcaaaaaaacgcCACAGCTTATATTAATCCTGACCAGCCTTTAATGCAGGGCATCCTCATATCAGAGGATGACATACGAAGGCAAGAGGATCGTGTTAGTGTGGCACGACGAAAACtgcaagaatttttaaaagtttaa
Protein Sequence: MQMNSNISIERKKVDCNALPKGWQKEDVLRKSGISAGKVDVYYYSPTGKRIDSKPQLARYLGDAIDISSFDFQKGKFIQHLPSPSISLYRCIPGNSAVVSSSGASTSGSAGITLAAAGSGSTTLPTLGGGITIIPSHHSSAGHNLKRKNRMGSQSALQNLPSSSSTSISSHHNLLLNSCTTPTLMTTTTSTNLPFKQQQLEFSRAMRTDISMVPPIRQTASIFKQPVTVIRNHEGSKTKNDAKQGAQDKPKQLFWEKRLEHMRACHSTGEQVDDIVLPKSLKPLGPNVHEQTVMQSLATALHVLNTPVTGQTATKTEFQKNATAYINPDQPLMQGILISEDDIRRQEDRVSVARRKLQEFLKV

Sequence clustering based on sequence similarity using MMseqs2