Ptra011910.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Philereme transversata
Gene Symbol
Mef2
Assembly
GCA_963924445.1
Location
OZ004342.1:18992909-19003662[-]

Transcription Factor Domain

TF Family
SRF
Domain
SRF domain
PFAM
PF00319
TF Group
Helix-turn-helix
Description
Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 2.4e-28 2.3e-24 85.6 0.4 1 48 10 57 10 57 0.99

Sequence Information

Coding Sequence
ATGGGCCGGAAGAAAATACAAATATCCCGGATCACGGACGAACGGAATCGACAGGTGACGTTCAACAAGCGTAAGTTCGGCGTGATGAAGAAAGCGTACGAACTCAGCGTCCTCTGCGATTGCGAGATTGCTCTCATCATCTTCAGCTCCAACAACAAACTCTACCAATATGCTAGCACTGATATGGATAAGGTTCTTCTGAAATACACGGAATACAACGAGCCGCACGAATCACTCACAAACCGCAACATCATCGAGGCACTAACGAAGAAAGAGCATAAGAACGGAGTGATGTCCCCTGACAGCCCTGAACAAGAGCCCGAATACAACCTGACCCCCCGCACCGAAGCCAAATACTCCAAGATTGACGAAGAATTCCAGATGATGATGCAAAGGAACCAGTTGAACGGAAGCCGAGTTGGAGTTGGTGTGACCGGAAGCAATTATAATCTACCAGTGAGCGTGCCAGTCGGAAGTTATGATCAATCTTTGTTGCAAGCCAGTCCTCAGATGCATACCTCTATCAGTCCACGGCCATCGTCTTCGGAAACCGATTCAGTCTACCCAAGCGGCGGAATGCTCGAAATGTCAAACGGCTACCCCGGATCAGGATCTCCCCTCGGCGCTGGATGTACTCCCTCCCCCTCACCAGGACCGGCGCCCTCCCCCCATCGACACCCGCACAAGCACCATGCTCCGCCGCCGCACCATTCGCCCCGACATAACAACCTACGCGTAGTCATACCGAGCTCGATGCCGCCACCTCAAGACGACCTATCATACACTGGAGAAACACCATTAAGCTACTCAGGACTTGGAAACTTCGGACCGCAGGATTTTAGTATGAGCTCGGACATGGGAATTGGACTGACGTGGGGCGCGCACCAACTGCAGACGTTGCAGCACAATAGGTACATTAGCAGCTTGCCAGTCCTGGGTGGAGGAGGGACGCCGCCGCCGTCTGCATCGCCTAGCAACGTGAAGATCAAAGCAGAACCCGTGTCCCCCCCTCGGGCGCCGGACCACATGCATCGTGTGCCGCCCGCACCGCAGCCCGCACACCTGTCTGGAGCCATCGACGGTTCTGTCTCGTCAAGTAACATGGGCTCGCCGGCCGGACAGGACATGCGGCACTCGGCAGGACCACTGGACTACGAGCAGCCGCACACCAAGCGGCCGCGGATCGAGGGCTGGGCCACATAG
Protein Sequence
MGRKKIQISRITDERNRQVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSNNKLYQYASTDMDKVLLKYTEYNEPHESLTNRNIIEALTKKEHKNGVMSPDSPEQEPEYNLTPRTEAKYSKIDEEFQMMMQRNQLNGSRVGVGVTGSNYNLPVSVPVGSYDQSLLQASPQMHTSISPRPSSSETDSVYPSGGMLEMSNGYPGSGSPLGAGCTPSPSPGPAPSPHRHPHKHHAPPPHHSPRHNNLRVVIPSSMPPPQDDLSYTGETPLSYSGLGNFGPQDFSMSSDMGIGLTWGAHQLQTLQHNRYISSLPVLGGGGTPPPSASPSNVKIKAEPVSPPRAPDHMHRVPPAPQPAHLSGAIDGSVSSSNMGSPAGQDMRHSAGPLDYEQPHTKRPRIEGWAT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00687854;
90% Identity
iTF_01546625; iTF_01544859; iTF_01542944; iTF_00649986; iTF_01099810; iTF_00361603; iTF_00795683; iTF_01501091; iTF_00844326; iTF_00321572; iTF_01402692; iTF_01495754; iTF_01494285; iTF_01495021; iTF_00840276; iTF_00855863; iTF_01115676; iTF_01176157; iTF_00957925; iTF_01337728; iTF_01219749; iTF_01561094; iTF_00162791; iTF_00412487; iTF_01078183; iTF_01161351; iTF_01208168; iTF_01209249; iTF_01508040; iTF_01507194; iTF_01079869; iTF_01543912; iTF_00276393; iTF_00673481; iTF_01312201; iTF_01335913; iTF_00255883; iTF_01041732; iTF_01436068; iTF_00144549; iTF_01403408; iTF_01071604; iTF_00994329; iTF_00077458; iTF_01503860; iTF_00035637; iTF_00034708; iTF_01336821; iTF_00715767; iTF_00178136; iTF_00074489; iTF_00681626; iTF_00256893; iTF_01569310; iTF_00709215; iTF_01143072; iTF_01141641; iTF_00661259; iTF_00699147; iTF_00700099; iTF_00703942; iTF_00705992; iTF_00701967; iTF_00702879; iTF_00697322; iTF_00737459; iTF_00686322; iTF_00632734; iTF_00275244; iTF_01178541; iTF_01506317; iTF_01528269; iTF_00687854; iTF_01248110; iTF_00933732; iTF_00403787; iTF_00934740; iTF_00164343; iTF_00405882; iTF_01217471; iTF_00744613; iTF_00356175; iTF_00355134; iTF_00895919; iTF_00935704; iTF_00635388; iTF_00790241; iTF_00826947; iTF_01172356; iTF_00825714; iTF_00032889; iTF_00112473; iTF_00634461; iTF_00942799; iTF_01509584; iTF_01529168; iTF_00198097; iTF_00027730; iTF_00026829; iTF_00125106; iTF_00663058; iTF_00913586; iTF_01425911; iTF_01170578; iTF_01264594; iTF_00649075; iTF_00771059; iTF_00876147; iTF_00161524; iTF_00701044; iTF_00875284; iTF_00698293; iTF_00696452; iTF_00834613; iTF_01279233; iTF_01125442; iTF_01437026; iTF_01281316; iTF_00682406; iTF_00874439; iTF_01451432; iTF_00204329; iTF_00837514; iTF_01316330; iTF_00960908; iTF_01083308; iTF_01367885; iTF_01443822; iTF_00824721; iTF_00006259; iTF_00835573; iTF_01282265; iTF_01416761; iTF_00761657; iTF_00007066; iTF_01251715; iTF_00836538; iTF_01140891; iTF_01075420; iTF_00076510; iTF_00114078; iTF_00236606; iTF_00235834; iTF_01453246; iTF_01452299; iTF_00723935; iTF_01080693; iTF_01317269; iTF_00187138; iTF_00406730; iTF_00407563; iTF_00468151; iTF_00007990; iTF_00806710; iTF_00021303; iTF_00462369; iTF_00155276; iTF_01134768; iTF_00325361; iTF_01135732; iTF_00022775; iTF_00156222; iTF_00342178; iTF_00010052; iTF_01133706; iTF_01464138; iTF_00009005; iTF_00411439; iTF_01245915; iTF_00119575; iTF_01171447; iTF_01401271; iTF_00318072; iTF_01072472; iTF_00660289; iTF_00680520; iTF_00409259; iTF_00658380; iTF_00289592; iTF_00656121; iTF_01564632; iTF_00909689; iTF_00662202; iTF_00467387; iTF_01079036; iTF_00638621; iTF_00856605; iTF_00377086; iTF_00674270; iTF_00044479; iTF_00150527; iTF_00704991; iTF_00827935; iTF_01090751; iTF_01545727; iTF_01561983; iTF_00710179; iTF_00357478; iTF_00358538; iTF_01193566; iTF_00055392; iTF_00818319; iTF_00811008; iTF_01429024; iTF_01463232;
80% Identity
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