Basic Information

Insect: Eumaeus atala
Gene Symbol: Mef2
Assembly: GCA_017140195.1
Location: JAOYMN010000012.1:2591809-2599630[-]

Transcription Factor Domain

TF Family: SRF
Domain: SRF domain
PFAM: PF00319
TF Group: Helix-turn-helix
Description: Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3.2e-23 1.9e-19 69.2 0.4 7 48 23 64 19 64 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3.2e-23	1.9e-19	69.2	0.4	7	48	23	64	19	64	0.93

Sequence Information

Coding Sequence: ATGACGTCACGCGTCGGCCGACCAATGGGGGGGACAGCGCACTCGCCCGGCCGCAGTGCTAGCCGCCGCGCCTTCGTGACATTCAACAAACGGAAATTTGGTGTCATGAAGAAGGCATACGAGCTGAGTGTCCTCTGCGACTGCGAGATTGCTCTCATCATTTTCAGTTCCAACAACAAACTGTACCAATACGCTAGCACGGACATGGATAAGGTACTATTGAAGTACACGGAGTACAATGAGCCGCACGAGTCGCTGACGAACCGGAACATCATCGAGGCACTAACGAAGAAAGAGCATAAGAACGGAGTAATGTCACCGGACAGTCCCGAGGCGGAACCCGAATACAACCTGACACCACGGACCGAGGCCAAATATTCAAAAATTGACGAGGAATTTCAAATGATGATGCAAAGGAACCAGCAGTTGAACGGAAGCCGAGTGGGAGTTGGCGTGACCGGAAGCACCTACAACCTGCCAGTGAGCGTGCCAGTCGGGAGCTATGATCAGTCACTTCTTCAAGCCAGTCCACAAATGCACACTTCGATCAGTCCACGGCCGTCGTCTTCGGAAACCGATTCTGTATACCCAAGCGGAGGAATGCTAGAGATGTCTAACGGTTACCCCGGCTCGGGGTCCCCTCTGGACGGCGGATGCACCCCTTCCCCCTCCCCGGGGCCGGCGCCGTCGCCACATCGCCACCACAAGGCGCACCACCCGCCGCCGCACCACTCGCCTCGCCACAATAACTTACGCGTCGTCATACCGAACTCCATGCCACCACCACAGGACGATCTATCTTACACAGGAGAGACACCACTCAGCTATTCAGGACTCGGCAATTTCGGCGGACCACAGGACTTCAGCATGACCTCGGACATCGGCATCGGACTATCATGGGGAGCGCACCAGCTGCAGACACTACAGCACAACAGGTACATTAGCGGCTTACCGGTGCTCGGAGGGGGCACCCCGCCACCGGCTGCGTCACCTGGGAACGTAAAGATCAAGGCCGAACCGGTGTCACCCCCGCGGGCACCCGACCACATGCACCGCGCGCCGCAGTCCGCCCCGCAGCCCGCGCACCTCGCTGCTGTTATCGATGGTTCAGTGACATCGAGTAACATGGGATCACCGGCTGGGCAAGACATGAGGCACTCCAACACCGTCCCACTCGACTATGAGCAGCCACACACAAAACGGCCGCGGATCGAAGGCTGGGCCACATAG
Protein Sequence: MTSRVGRPMGGTAHSPGRSASRRAFVTFNKRKFGVMKKAYELSVLCDCEIALIIFSSNNKLYQYASTDMDKVLLKYTEYNEPHESLTNRNIIEALTKKEHKNGVMSPDSPEAEPEYNLTPRTEAKYSKIDEEFQMMMQRNQQLNGSRVGVGVTGSTYNLPVSVPVGSYDQSLLQASPQMHTSISPRPSSSETDSVYPSGGMLEMSNGYPGSGSPLDGGCTPSPSPGPAPSPHRHHKAHHPPPHHSPRHNNLRVVIPNSMPPPQDDLSYTGETPLSYSGLGNFGGPQDFSMTSDIGIGLSWGAHQLQTLQHNRYISGLPVLGGGTPPPAASPGNVKIKAEPVSPPRAPDHMHRAPQSAPQPAHLAAVIDGSVTSSNMGSPAGQDMRHSNTVPLDYEQPHTKRPRIEGWAT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00933732; iTF_00403787; iTF_01178541; iTF_00934740; iTF_00164343; iTF_00405882; iTF_01217471; iTF_01017706; iTF_00205098; iTF_01018542; iTF_00779478; iTF_01021206; iTF_00462369; iTF_00647969; iTF_00723041; iTF_00159815; iTF_00213422; iTF_00621208; iTF_00212441; iTF_00248057; iTF_00247165; iTF_00726337; iTF_00037794; iTF_00758148; iTF_00831205; iTF_00274407; iTF_00122376; iTF_00120489; iTF_00273581; iTF_00121423; iTF_00177103; iTF_00425362; iTF_01246962; iTF_00237557; iTF_00907861; iTF_00071417; iTF_00810044; iTF_00809117; iTF_00771905; iTF_00790241; iTF_00820065; iTF_00850721; iTF_00973761; iTF_01546625; iTF_01561094; iTF_01544859; iTF_01542944; iTF_00711842; iTF_01084244; iTF_01063740; iTF_01064642; iTF_01533027; iTF_00685417; iTF_00928682; iTF_01061870; iTF_01531996; iTF_01094018; iTF_00745677; iTF_00667470; iTF_00924660; iTF_01093076; iTF_00124247; iTF_00123355; iTF_01437026; iTF_00195139; iTF_00783459; iTF_00826947; iTF_01076483; iTF_01091907; iTF_00801825; iTF_01230563; iTF_01028273; iTF_01031123; iTF_00888246; iTF_01030205; iTF_01029246; iTF_01251715; iTF_00761657; iTF_01416761; iTF_00007066; iTF_00010052; iTF_00300196; iTF_00428100; iTF_00819144; iTF_01429915; iTF_01436068; iTF_01527204; iTF_00871269; iTF_00951813; iTF_00364006; iTF_00791174; iTF_00851782; iTF_01078182; iTF_01197702; iTF_00282375; iTF_00412487; iTF_00874439; iTF_00954439; iTF_01078183; iTF_01117191; iTF_01508040; iTF_01507194; iTF_01079869; iTF_01543912; iTF_01138921; iTF_01312201; iTF_01027306; iTF_01133706; iTF_01464138; iTF_01502954; iTF_00255883; iTF_00144549; iTF_00842650; iTF_00986074; iTF_00683339; iTF_00682406; iTF_00382587; iTF_01334876; iTF_01333803; iTF_01331557; iTF_01439915; iTF_01452299; iTF_01451432; iTF_01453246; iTF_00878828; iTF_00960908; iTF_01205676; iTF_01203214; iTF_01204015; iTF_01206526; iTF_00009005; iTF_01506317; iTF_00147438; iTF_01285518; iTF_01362414; iTF_01441070; iTF_01443822; iTF_00356175; iTF_00411439; iTF_01020271; iTF_01119311; iTF_01118290; iTF_00111640; iTF_01221551; iTF_00063568; iTF_01338736; iTF_01403408; iTF_01071604; iTF_00827935; iTF_00325361; iTF_00824721; iTF_01026161; iTF_01151185; iTF_00077458; iTF_00374098; iTF_00825714; iTF_00913586; iTF_01264594; iTF_00876147; iTF_00907027; iTF_01425043; iTF_00034708; iTF_00447124; iTF_00657172; iTF_00875284; iTF_01135732; iTF_01134768; iTF_01503860; iTF_00035637; iTF_00171733; iTF_01080693; iTF_01336821; iTF_00806710; iTF_00859446; iTF_01533910; iTF_00021303; iTF_00022775; iTF_00043479; iTF_00039792; iTF_00318839; iTF_01171447; iTF_01401271; iTF_01425911; iTF_00178136; iTF_00654264; iTF_00695576; iTF_01072472; iTF_00660289; iTF_00680520; iTF_00409259; iTF_00658380; iTF_00289592; iTF_00656121; iTF_01192696; iTF_00032889; iTF_00794585; iTF_01340089; iTF_01534809; iTF_01062779; iTF_01085215; iTF_00772858; iTF_00148444; iTF_00622811; iTF_00906132; iTF_00677595; iTF_00952699; iTF_01140891; iTF_01245915; iTF_00040796; iTF_00375196; iTF_01079036; iTF_01147356; iTF_01148787; iTF_01149564; iTF_01146183; iTF_01140177; iTF_01148062; iTF_00256893; iTF_00449085; iTF_00634461; iTF_00149374; iTF_00156222; iTF_00155276; iTF_00236606; iTF_00235834; iTF_00281310; iTF_00689374; iTF_00785182; iTF_01569310; iTF_00018143; iTF_00044479; iTF_00150527; iTF_00704991; iTF_01081567; iTF_01090751; iTF_00038752; iTF_00036702; iTF_00055392; iTF_00818319; iTF_01143072; iTF_01141641; iTF_01337728; iTF_01358848; iTF_01010335; iTF_01463232; iTF_00419733; iTF_00361603; iTF_00780227; iTF_00780997; iTF_00458025; iTF_00457208; iTF_00775227; iTF_00777980; iTF_00795683; iTF_01204867; iTF_01501091; iTF_00844326; iTF_01041732; iTF_00007990; iTF_01402692; iTF_00957925; iTF_01153958; iTF_01495754; iTF_01494285; iTF_01495021; iTF_00840276; iTF_00855863; iTF_00197340; iTF_01115676; iTF_01176157; iTF_00180448; iTF_01219749; iTF_00357478; iTF_01341254; iTF_01161351; iTF_00013000; iTF_00651724; iTF_00072795; iTF_01437960; iTF_00204329; iTF_00276393; iTF_00673481; iTF_01335913; iTF_01547529; iTF_00358538; iTF_00697322; iTF_01181866; iTF_00661259; iTF_01016651; iTF_00114924; iTF_00249676; iTF_00275244; iTF_00796492; iTF_00960140; iTF_00958643; iTF_00959379; iTF_01083308; iTF_00354061; iTF_00640301; iTF_01302316; iTF_00839405; iTF_01528269; iTF_00720271; iTF_00777359; iTF_00942799; iTF_00970383; iTF_01082418; iTF_00971347; iTF_01033711; iTF_01034565; iTF_01280271; iTF_00786768; iTF_00341297; iTF_00027730; iTF_00026829; iTF_00663058; iTF_00686322; iTF_00953490; iTF_01170578; iTF_01182866; iTF_00649075; iTF_00737459; iTF_00771059; iTF_00887379; iTF_00896787; iTF_00932531; iTF_00889192; iTF_01152137; iTF_00869610; iTF_00931385; iTF_00709215; iTF_01130003; iTF_00161524; iTF_00701044; iTF_00736597; iTF_00835573; iTF_01222454; iTF_00119575; iTF_00782615; iTF_01220631; iTF_00146401; iTF_00318072; iTF_01564632; iTF_00074489; iTF_00277337; iTF_00288025; iTF_00353049; iTF_00421337; iTF_00418963; iTF_00909689; iTF_00985081; iTF_01282265; iTF_01279233; iTF_00448115; iTF_01438905; iTF_00858522; iTF_01158938; iTF_00345787; iTF_00172932; iTF_01075420; iTF_00011965; iTF_00856605; iTF_00076510; iTF_00355134; iTF_00377086; iTF_00662202; iTF_00632734; iTF_00674270; iTF_01142366; iTF_01193566; iTF_00075519; iTF_01124570; iTF_00723935; iTF_01144511; iTF_01545727; iTF_01561983; iTF_00710179; iTF_00323488; iTF_00461536; iTF_01155168; iTF_01156428; iTF_01429024; iTF_00642296; iTF_00342178;
90% Identity: iTF_01182866;
80% Identity: -