SRF
- Domain
- SRF domain
- Group
- Helix-turn-helix
- PFAM
- PF00319
- Desciption
- Serum response factor (SRF) is a ubiquitous nuclear protein important for cell proliferation and differentiation. SRF function is essential for transcriptional regulation of numerous growth-factor-inducible genes, such as c-fos oncogene and muscle-specific actin genes. A core domain of around 90 amino acids is sufficient for the activities of DNA-binding, dimerisation and interaction with accessory factors. Within the core is a DNA-binding region, designated the MADS box [2], that is highly similar to many eukaryotic regulatory proteins: among these are MCM1, the regulator of cell type-specific genes in fission yeast; DSRF, a Drosophila trachea development factor; the MEF2 family of myocyte-specific enhancer factors; and the Agamous and Deficiens families of plant homeotic proteins. In SRF, the MADS box has been shown to be involved in DNA-binding and dimerisation [1]. Proteins belonging to the MADS family function as dimers, the primary DNA-binding element of which is an anti-parallel coiled coil of two amphipathic α-helices, one from each subunit. The DNA wraps around the coiled coil allowing the basic N-termini of the helices to fit into the DNA major groove. The chain extending from the helix N-termini reaches over the DNA backbone and penetrates into the minor groove. A 4-stranded, anti-parallel β-sheet packs against the coiled-coil face opposite the DNA and is the central element of the dimerisation interface. The MADS-box domain is commonly found associated with K-box region see (IPR002487).
- Rederence
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- Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element. Norman C, Runswick M, Pollock R, Treisman R. Cell 55, 989-1003, (1988).
- Structure of serum response factor core bound to DNA. Pellegrini L, Tan S, Richmond TJ. Nature 376, 490-8, (1995).
Statistic of Transcription Factors
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Transcription Factor Table
| Gene ID | Insect | Gene Name | Gene Symbol |
|---|---|---|---|
| iTF_00000313 | Abrostola tripartita | Atri012070.1 | Mef2 |
| iTF_00000314 | Abrostola tripartita | Atri008458.1 | bs |
| iTF_00000315 | Abrostola tripartita | Atri008457.1 | bs |