Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 2.4e-22 1.1e-18 66.7 0.0 1 65 55 121 55 121 0.92

2 3 1.8 8.5e+03 -3.4 0.0 11 29 127 144 126 145 0.69

3 3 3.5e-17 1.6e-13 50.2 0.1 1 64 156 246 156 247 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	2.4e-22	1.1e-18	66.7	0.0	1	65	55	121	55	121	0.92
2	3	1.8	8.5e+03	-3.4	0.0	11	29	127	144	126	145	0.69
3	3	3.5e-17	1.6e-13	50.2	0.1	1	64	156	246	156	247	0.90

Coding Sequence: ATGTATGAAGATGACAACATAACTTGTACCCCAAAGCGTTGTGTGCTTACTGAAGTTACAAATTCCACCAACTATGTGTCACCGACTGCCAACCTCAAATTGTTGACCAATGTCGCGCTGCAGTATCCCACACCGCCTCCGGAAAGGAGTGCCGTACATCGGAAAGAAAAATCCTTACAGATATTATGTGACAGATTTCTTAATTTGTATCCTCTCCATGGGGATGGTCCAGTGGAGATACAGCTGGATAGCACTGCAGCCCGGCTAGGCGTCGAGAAGCGGCGCATGTACGACATCATAAACATATTAGAAGCTATGCAGTGTGCTGTTCACAAAAGAAAGAACACATACCTTTGGCATGGAGGATCTCGACTAAATTCATTTTTGAAGATGCTTAAAAAGCAAGGGGAGCACCTGCGACTGTCAGAGGCGCTGCGTGGAAGAGCACCCAAGCCTCCCACTCCTAAAAATAAAACTTTGGGTGTGTTAGCGCAAAGATTCTTGATGTTATTTTTGGTAGAACCTCCTAATACTCTTATCAACTTGGAGATGGCTGTGAGGGTGCTCATAGACACATCCAGCAAGAGCAAGACTGTTCTGTCGCCAGAGCAACTGGACCGCCAGCATAAGTCCAAAGTGAGGCGACTCTATGATATTGCCAATGTATTTATTTCAATTGGTCTCATTGAGAAGGTATCAGGTAATTTAATTTTAAAGAAGCCAGTTTTTAAATATGTTGGGCCACATAAGATGAAAAAGTCCGACAAGATGGTGCTCACAATGCCGTCCCCTATGACTCCACTGTCAGTGTTGGACAGTCAGCAGCGAGCCACACCCTGCCATGTGTATGCCGGGCGGTCCAAACGGAAACTGGAGTTCACCACTCCAACTTCCACCAAAGAACTGAAGCTTGGCATCACAACCCCACCTCACACGCCGTCGCACAAGTGGGATGAAATCTTGCTCGTCGCTGACATGGAACTGACTAGAATTAACAATGGAGTAGTGTTGTGA
Protein Sequence: MYEDDNITCTPKRCVLTEVTNSTNYVSPTANLKLLTNVALQYPTPPPERSAVHRKEKSLQILCDRFLNLYPLHGDGPVEIQLDSTAARLGVEKRRMYDIINILEAMQCAVHKRKNTYLWHGGSRLNSFLKMLKKQGEHLRLSEALRGRAPKPPTPKNKTLGVLAQRFLMLFLVEPPNTLINLEMAVRVLIDTSSKSKTVLSPEQLDRQHKSKVRRLYDIANVFISIGLIEKVSGNLILKKPVFKYVGPHKMKKSDKMVLTMPSPMTPLSVLDSQQRATPCHVYAGRSKRKLEFTTPTSTKELKLGITTPPHTPSHKWDEILLVADMELTRINNGVVL

Sequence clustering based on sequence similarity using MMseqs2