Basic Information

Transcription Factor Domain

TF Family: E2F
Domain: E2F_TDP domain
PFAM: PF02319
TF Group: Helix-turn-helix
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 4.8e-23 1.2e-18 68.6 0.0 1 65 52 118 52 118 0.92

2 3 1.4 3.4e+04 -3.4 0.0 11 29 124 141 123 142 0.65

3 3 2.1e-17 5.3e-13 50.5 0.1 1 64 153 243 153 244 0.89

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	4.8e-23	1.2e-18	68.6	0.0	1	65	52	118	52	118	0.92
2	3	1.4	3.4e+04	-3.4	0.0	11	29	124	141	123	142	0.65
3	3	2.1e-17	5.3e-13	50.5	0.1	1	64	153	243	153	244	0.89

Coding Sequence: ATGTATGAGAATGATAACATAACTTCTACTCCGAAGCGATGTGCCCTTACTGAAGTCACGAACTCAAGTTATGTATCTCCTACTGCTAACCTGAAGCTTTTAACTAATGTCGCCTTACAGTATCCCACGCCGCCTCCAAGTGCAGTGCATCGAAAAGAAAAATCTTTGCAAATATTATGTGACAAatttcTTAACCTATATCCCCTACACTGCAATGGAACTATGGAAATTCAGTTGGACAGCACTGCGGCCAGACTAGGAGTAGAAAAGCGACGAATGTAtgacattataaatattttggaagCAATGCAATGTGCGgttcataaaagaaaaaatacttacctatgGCATGGAGGATCTAGGctaaattcttttttaaaaatgttgaagAAACAAGGGGAAAATCTACGCTTGTCTGAGGCTTTGAGGGGTAGGGCTCCTAAGCCACCTGCTCCTAAACATAAAACACTTGGAGTCTTGGCTCAGAGATTTCTGATGCTTTTTTTAGTAGAACCACAAaatacTCTCATAAATTTAGAGATGGCTGTGAAAGTACTTATAGACACatctaacaaaaacaaaactgaCCTCTCTCCAGAGCAACTGGATCGTCAACACAAGTCCAAAGTGAGGAGACTCTACGATATCGCCAATGTATTCATATCAATTGGTCTGATTGAAAAAGTTTCtggtaatttaatattaaagaaaccaGTGTTTAAGTATGTAGGACCTTATAAAATAAGAAAGCCTGATAAGGCTGCAGTCACAATACCTTCACCAATAACTCCACTCTCAGTGTTGGATACACAACAAAAAATTACTCCTTGCCATGTATTTGCCAGTAGGTCGAAACGAAAGTTGGAGTTTACTACACCAGACACTGATACAAAACTTGGTGTTACAACTCCTCCGGACACACCGTCACACAAATGGGATGAAATCTTGCTTGTGGCTAACATGGAACTGAATAGAATTAACAATGGTATTTTGTtgtga
Protein Sequence: MYENDNITSTPKRCALTEVTNSSYVSPTANLKLLTNVALQYPTPPPSAVHRKEKSLQILCDKFLNLYPLHCNGTMEIQLDSTAARLGVEKRRMYDIINILEAMQCAVHKRKNTYLWHGGSRLNSFLKMLKKQGENLRLSEALRGRAPKPPAPKHKTLGVLAQRFLMLFLVEPQNTLINLEMAVKVLIDTSNKNKTDLSPEQLDRQHKSKVRRLYDIANVFISIGLIEKVSGNLILKKPVFKYVGPYKIRKPDKAAVTIPSPITPLSVLDTQQKITPCHVFASRSKRKLEFTTPDTDTKLGVTTPPDTPSHKWDEILLVANMELNRINNGILL

Sequence clustering based on sequence similarity using MMseqs2